Çocukluk Çağı Büyüme Hormonu Eksikliğinde Büyüme Hormonu Tedavisinin Optimizasyonu

Yıl 2014, Cilt: 14 Sayı: 4, 148 - 155, 01.10.2014

Feyza Darendeliler

https://doi.org/10.5222/j.child.2014.148

Öz

Büyüme hormonu eksikliğinde BHE tanı ve tedavi süreci oldukça zorlu olup, gerek tanı kriterleri gerekse hangi çocuklara tedavi verilmesi gerektiği konusunda henüz tam bir görüş birliği yoktur. Büyüme bozukluklarının optimal tedavisi etiyolojinin doğru tanılanması ve gerçekçi tedavi hedeflerinin belirlenmesi ile olası olup, tedavi altındaki hastaların etkililik ve güvenlilik açısından yakın izlemi, izlem sürecinde tedavi yanıtı değerlendirilerek yetersiz yanıt durumunda ilgili faktörlerin belirlenmesi ve uygun doz ayarlamalarının yapılması BH tedavisinin optimizas- yonunun kritik bileşenlerindendir. Bu derleme makalesin- de, büyüme hormonu BH yerine koyma tedavisi hedefleri ve tedavi yanıtını etkileyen faktörler, büyüme yanıtı öngörü modelleri, yetersiz tedavi yanıtının değerlendirilmesi, BH tedavisi izlemi ve BH tedavisinin kesilmesi açısından değerlendirilmektedir

Anahtar Kelimeler

Büyüme hormonu eksikliği, büyüme hormonu tedavisi, tedavi optimizasyonu

Optimizing Growth Hormone Therapy in Chilhood Growth Hormone Defiency

Öz

The diagnosis and treatment of growth hormone deficiency GHD are challenging issues with no clear-cut consensus on the diagnostic criteria and which children should be treated. Optimal treatment of growth disorders depends on accurate definition of underlying etiology and identificati- on of realistic treatment targets. Close follow up of treated patients in terms of efficacy and safety of treatment as well as evaluation of treatment response with identification of responsible factors and implementing appropriate dose adjustment in case of insufficient treatment response are critical factors in opimizing growth hormone GH therapy. In this review, optimal treatment of GHD has been evalua- ted in terms of targets of GH replacement therapy, factors affecting treatment response, growth response prediction models, assessment of insufficient treatment response, monitorization, and discontinuation of GH treatment

Anahtar Kelimeler

Growth hormone deficiency, growth hormone therapy, treatment optimization

Kaynakça

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