BibTex RIS Kaynak Göster

İki Vaka Nedeniyle PFAPA Sendromu

Yıl 2011, Cilt: 11 Sayı: 4, 177 - 180, 01.10.2011
https://doi.org/10.5222/j.child.2011.177

Öz

Yineleyen veya periyodik ateş yakınmasına çocuk hekimli- ğinde nispeten sık rastlanmaktadır. PFAPA sendromu, yük- sek ateş, servikal lenfadenopati, aftöz stomatit ve farenjit ile karakterizedir. Sekiz yaşında kız hasta olan ilk vakanın 3-4 haftada bir yineleyen ateş, farenjit ve aftöz stomatit atakları vardı. Ateşli dönem 5-6 gün sürmekte antibiyotik tedavisine yanıt alınamamaktaydı. Atak sırasında akut faz reaktanlarının yükseldiği ve ataklar arasında tamamen normale döndüğü saptandı. Bu bulgularla hastada PFAPA sendromu düşünüldü. Hastanın yakınmaları tek doz predni- zon ile dramatik bir şekilde düzeldi. Üç buçuk yaşında erkek hasta olan ikinci vakanın ayda bir membranöz tonsil- lit, yüksek ateş yakınmaları vardı. Atakların bazılarında servikal lenfadenopati gözlenirken, aftöz stomatit hiç olmu- yordu. Ataklar sırasında antibiyotik kullanımına rağmen, ateş 5-6 gün sürüyor ve akut faz reaktanları yüksek olarak bulunuyordu. Atak sırasında tek doz prednizon tedavisine yanıt veren hastaya PFAPA tanısı kondu. PFAPA sendromu- nun 5 yaş üzeri de görülebileceğini, aftöz stomatit olmadan da tanı koyulabileceğini vurgulamak ve iki atipik vaka nedeniyle PFAPA sendromunu vurgulamak ve literatürü derlemek istedik

Kaynakça

  • 1. Feder HM Jr. Periodic fever, aphthous stomatitis, pharyngitis, adenitis: a clinical review of a new syndrome. Curr Opin Pediatr 2000;12(3):253-6. http://dx.doi.org/10.1097/00008480-200006000-00014 PMid:10836162
  • 2. Scholl P. Periodic fever syndromes. Curr Opin Pediatr 2000;12(6):563-6. http://dx.doi.org/10.1097/00008480-200012000-00009 PMid:11106276
  • 3. John CC, Gilsdorf JR. Recurrent fever in children. Pediatr Infect Dis J 2002;21(11):1071-80. http://dx.doi.org/10.1097/00006454-200211000-00020 PMid:12442033
  • 4. Marshall GS, Edwards KM, Butler J, Lawton AR. Syndrome of periodic fever, pharyngitis, and aphtous stomatitis. J Pediatr 1987;110(1):43-6. http://dx.doi.org/10.1016/S0022-3476(87)80285-8
  • 5. Thomas KT, Feder HM Jr, Lawton AR, Edwards KM, et al. Periodic fever syndrome in children. J Pediatr 1999; 135(1):15-21. http://dx.doi.org/10.1016/S0022-3476(99)70321-5
  • 6. Padeh S, Brezniak N, Zemer D, Pras E, Livneh A, Langevitz P. Periodic fever, aphtous stomatitis, pharyngitis and adenopathy syndrome: clinical characteristics and outcome. J Pediatr 1999;135(1):98-101. http://dx.doi.org/10.1016/S0022-3476(99)70335-5
  • 7. Long SS. Syndrome of periodic fever, aphtous stomatitis, pharyngitis, and adenitis (PFAPA): what it isn’t. What is it? J Pediatr 1999;135(1):1-5. http://dx.doi.org/10.1016/S0022-3476(99)70316-1
  • 8. Marshall GS, Edwards KM. PFAPA syndrome. Pediatr Infect Dis J 1989;8(9):658-9. http://dx.doi.org/10.1097/00006454-198909000-00026 PMid:2797967
  • 9. Stojanov S, Hoffmann F, Kery A, Renner ED, Hartl D, Lohse P, et al. Cytokine profile in PFAPA syndrome suggests continuous inflammation and reduced anti-inflammatory response. Eur Cytokine Netw 2006;17(2):90-7. PMid:16840027
  • 10. Galanakis E, Papadakis CE, Giannoussi E, Karatzanis AD, Bitsori M, Helidonis ES. PFAPA syndrome in children evaluated for tonsillectomy. Arch Dis Child 2002;86(6):434- 435. http://dx.doi.org/10.1136/adc.86.6.434 PMid:12023179 PMCid:1762991
  • 11. Feder HM Jr. Cimetidine treatment for periodic fever associated with aphthous stomatitis, pharyngitis, and cervical adenitis. Pediatr Infect Dis J 1992;11(4):318-21. http://dx.doi.org/10.1097/00006454-199204000-00011 PMid:1565557
  • 12. Tasher D, Stein M, Dalal I, Somek E. Colchicine prophylaxis for frequent periodic fever, aphtous stomatitis, pharyngitis and adenitis episodes. Acta Paediatr 2008;97(8):1090-2. http://dx.doi.org/10.1111/j.1651-2227.2008.00837.x PMid:18462461
  • 13. Berkun Y, Levy R, Hurwitz A, Meir-Harel M, Lidar M, Livneh A, Padeh S. The familial Mediterranean fever gene as a modifier of periodic fever, aphthous stomatitis, pharyngitis, and adenopathy syndrome. Semin Arthritis Rheum 2011; 40(5):467-72. http://dx.doi.org/10.1016/j.semarthrit.2010.06.009 PMid:20828792
  • 14. Parikh SR, Reiter ER, Kenna MA, Roberson D. Utility of tonsillectomy in 2 patients with the syndrome of periodic fever, aphthous stomatitis, pharyngitis, and cervikal adenitis. Arch Otolaryngol Head Neck Surg 2003;129(6):670-3. http://dx.doi.org/10.1001/archotol.129.6.670 PMid:12810475
  • 15. Berlucchi M, Meini A, Plebani A, Bonvini MG, Lombardi D, Nicolai P. Update on treatment of Marshall’s syndrome (PFAPA syndrome): report of five cases with review of the literature. Ann Otol Rhinol Laryngol 2003;112(4):365-9. PMid:12731633
  • 16. Garavello W, Pignataro L, Gaini L, Torretta S, Somigliana E, Gaini R. Tonsillectomy in children with periodic fever with aphthous stomatitis, pharyngitis and adenitis syndrome. J Pediatr 2011: 5.

Two Cases with PFAPA Syndrome

Yıl 2011, Cilt: 11 Sayı: 4, 177 - 180, 01.10.2011
https://doi.org/10.5222/j.child.2011.177

Öz

Recurrent or periodic fever is seen frequently in pediatric medicine. Diagnostic criteria of PFAPA syndrome is cha- racterized by fever, cervical lymphadenopathy, aphthous stomatitis and pharyngitis. First case was a 8 year-old girl and she had recurrent attacks of fever, pharyngitis and aphthous stomatitis in every 3-4 weeks. Fever lasted 5-6 days and no response to antibiotics was received. Acute phase reactants elevated during the attacks and returned to normal between attacks. Symptoms of the patient dramati- cally returned to normal after single dose of prednisone. Second case was 3.5 year-old boy and he had recurrent attacks of membranous tonsillitis and high fever once a month. Cervical lymphadenopathy was observed in some of the attacks but without any aphthous stomatitis. Fever las- ted 5-6 days despite antibiotic use and acute phase reac- tants elevated. Symptoms of the patient returned to normal after a single dose of prednisone. We want both to empha- size PFAPA syndrome with two atypic patients and also review the literature

Kaynakça

  • 1. Feder HM Jr. Periodic fever, aphthous stomatitis, pharyngitis, adenitis: a clinical review of a new syndrome. Curr Opin Pediatr 2000;12(3):253-6. http://dx.doi.org/10.1097/00008480-200006000-00014 PMid:10836162
  • 2. Scholl P. Periodic fever syndromes. Curr Opin Pediatr 2000;12(6):563-6. http://dx.doi.org/10.1097/00008480-200012000-00009 PMid:11106276
  • 3. John CC, Gilsdorf JR. Recurrent fever in children. Pediatr Infect Dis J 2002;21(11):1071-80. http://dx.doi.org/10.1097/00006454-200211000-00020 PMid:12442033
  • 4. Marshall GS, Edwards KM, Butler J, Lawton AR. Syndrome of periodic fever, pharyngitis, and aphtous stomatitis. J Pediatr 1987;110(1):43-6. http://dx.doi.org/10.1016/S0022-3476(87)80285-8
  • 5. Thomas KT, Feder HM Jr, Lawton AR, Edwards KM, et al. Periodic fever syndrome in children. J Pediatr 1999; 135(1):15-21. http://dx.doi.org/10.1016/S0022-3476(99)70321-5
  • 6. Padeh S, Brezniak N, Zemer D, Pras E, Livneh A, Langevitz P. Periodic fever, aphtous stomatitis, pharyngitis and adenopathy syndrome: clinical characteristics and outcome. J Pediatr 1999;135(1):98-101. http://dx.doi.org/10.1016/S0022-3476(99)70335-5
  • 7. Long SS. Syndrome of periodic fever, aphtous stomatitis, pharyngitis, and adenitis (PFAPA): what it isn’t. What is it? J Pediatr 1999;135(1):1-5. http://dx.doi.org/10.1016/S0022-3476(99)70316-1
  • 8. Marshall GS, Edwards KM. PFAPA syndrome. Pediatr Infect Dis J 1989;8(9):658-9. http://dx.doi.org/10.1097/00006454-198909000-00026 PMid:2797967
  • 9. Stojanov S, Hoffmann F, Kery A, Renner ED, Hartl D, Lohse P, et al. Cytokine profile in PFAPA syndrome suggests continuous inflammation and reduced anti-inflammatory response. Eur Cytokine Netw 2006;17(2):90-7. PMid:16840027
  • 10. Galanakis E, Papadakis CE, Giannoussi E, Karatzanis AD, Bitsori M, Helidonis ES. PFAPA syndrome in children evaluated for tonsillectomy. Arch Dis Child 2002;86(6):434- 435. http://dx.doi.org/10.1136/adc.86.6.434 PMid:12023179 PMCid:1762991
  • 11. Feder HM Jr. Cimetidine treatment for periodic fever associated with aphthous stomatitis, pharyngitis, and cervical adenitis. Pediatr Infect Dis J 1992;11(4):318-21. http://dx.doi.org/10.1097/00006454-199204000-00011 PMid:1565557
  • 12. Tasher D, Stein M, Dalal I, Somek E. Colchicine prophylaxis for frequent periodic fever, aphtous stomatitis, pharyngitis and adenitis episodes. Acta Paediatr 2008;97(8):1090-2. http://dx.doi.org/10.1111/j.1651-2227.2008.00837.x PMid:18462461
  • 13. Berkun Y, Levy R, Hurwitz A, Meir-Harel M, Lidar M, Livneh A, Padeh S. The familial Mediterranean fever gene as a modifier of periodic fever, aphthous stomatitis, pharyngitis, and adenopathy syndrome. Semin Arthritis Rheum 2011; 40(5):467-72. http://dx.doi.org/10.1016/j.semarthrit.2010.06.009 PMid:20828792
  • 14. Parikh SR, Reiter ER, Kenna MA, Roberson D. Utility of tonsillectomy in 2 patients with the syndrome of periodic fever, aphthous stomatitis, pharyngitis, and cervikal adenitis. Arch Otolaryngol Head Neck Surg 2003;129(6):670-3. http://dx.doi.org/10.1001/archotol.129.6.670 PMid:12810475
  • 15. Berlucchi M, Meini A, Plebani A, Bonvini MG, Lombardi D, Nicolai P. Update on treatment of Marshall’s syndrome (PFAPA syndrome): report of five cases with review of the literature. Ann Otol Rhinol Laryngol 2003;112(4):365-9. PMid:12731633
  • 16. Garavello W, Pignataro L, Gaini L, Torretta S, Somigliana E, Gaini R. Tonsillectomy in children with periodic fever with aphthous stomatitis, pharyngitis and adenitis syndrome. J Pediatr 2011: 5.
Toplam 16 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Araştırma Makaleleri
Yazarlar

Burçin Nalbantoğlu Bu kişi benim

Metin Uysalol Bu kişi benim

Erkut Karasu Bu kişi benim

Burcu Özdilek Bu kişi benim

Yayımlanma Tarihi 1 Ekim 2011
Yayımlandığı Sayı Yıl 2011 Cilt: 11 Sayı: 4

Kaynak Göster

APA Nalbantoğlu, B., Uysalol, M., Karasu, E., Özdilek, B. (2011). İki Vaka Nedeniyle PFAPA Sendromu. Çocuk Dergisi, 11(4), 177-180. https://doi.org/10.5222/j.child.2011.177
AMA Nalbantoğlu B, Uysalol M, Karasu E, Özdilek B. İki Vaka Nedeniyle PFAPA Sendromu. Çocuk Dergisi. Ekim 2011;11(4):177-180. doi:10.5222/j.child.2011.177
Chicago Nalbantoğlu, Burçin, Metin Uysalol, Erkut Karasu, ve Burcu Özdilek. “İki Vaka Nedeniyle PFAPA Sendromu”. Çocuk Dergisi 11, sy. 4 (Ekim 2011): 177-80. https://doi.org/10.5222/j.child.2011.177.
EndNote Nalbantoğlu B, Uysalol M, Karasu E, Özdilek B (01 Ekim 2011) İki Vaka Nedeniyle PFAPA Sendromu. Çocuk Dergisi 11 4 177–180.
IEEE B. Nalbantoğlu, M. Uysalol, E. Karasu, ve B. Özdilek, “İki Vaka Nedeniyle PFAPA Sendromu”, Çocuk Dergisi, c. 11, sy. 4, ss. 177–180, 2011, doi: 10.5222/j.child.2011.177.
ISNAD Nalbantoğlu, Burçin vd. “İki Vaka Nedeniyle PFAPA Sendromu”. Çocuk Dergisi 11/4 (Ekim 2011), 177-180. https://doi.org/10.5222/j.child.2011.177.
JAMA Nalbantoğlu B, Uysalol M, Karasu E, Özdilek B. İki Vaka Nedeniyle PFAPA Sendromu. Çocuk Dergisi. 2011;11:177–180.
MLA Nalbantoğlu, Burçin vd. “İki Vaka Nedeniyle PFAPA Sendromu”. Çocuk Dergisi, c. 11, sy. 4, 2011, ss. 177-80, doi:10.5222/j.child.2011.177.
Vancouver Nalbantoğlu B, Uysalol M, Karasu E, Özdilek B. İki Vaka Nedeniyle PFAPA Sendromu. Çocuk Dergisi. 2011;11(4):177-80.