Büyüme Hormonunun Tedavisinde Kanıta Dayalı Uygulamalar

Yıl 2009, Cilt: 9 Sayı: 4, 158 - 166, 01.10.2009

Feyza Darendeliler

Öz

Büyüme hormonu BH tedavisi giderek daha çok sayıda BH eksikliği BHE vakasında ve ayrıca, BHE dışında boy kısalığı ile giden çeşitli hastalıklarda uygulanmaya başlandı. BH tedavisinin amacı kısa dönemde büyüme hızını arttırmak ve uzun dönemde nihai boyun iyileştirilmesini sağlamaktır. BHE’de fizyolojik, BHE dışındaki diğer uygulamalarda ise daha yüksek BH dozları verilmektedir. BH tedavisine büyüme yanıtını etkileyen çeşitli faktörler vardır. Bu faktörler arasında BH verilme sıklığı, diğer hormonların varsa eksikliklerinin yerine konması, beslenme durumu, tedaviye başlama yaşı, BH dozu ve tedavi süresi sayılabilir. Tedavi hergün uygulanırsa, ne kadar erken yaşta başlanırsa ve uygun dozlarda verilirse büyüme yanıtı o kadar iyidir. Büyüme yanıtı özellikle prepubertal dönemde yüksektir. Bu derlemede BH tedavisinin çocukluk döneminde büyüme üzerine etkileri ve olası yan etkileri farklı hastalık gruplarında kanıta dayalı olarak sunulmaktadır

Anahtar Kelimeler

Büyüme hormonu, çocukluk çağı, büyüme, yan etki

Growth Hormone Therapy in Childhood: EvidenceBased Approach

Öz

Growth hormone GH is being used in GH deficiency GHD and also in recent years in other indications that go with short stature. The aim of GH therapy is to increase the growth velocity at short term and improve final adult height at longterm. Physiological doses of GH are used in GHD and higher doses in non- GHD conditions. There are several factors that have an effect on the growth response on GH treatment. The frequency of injections, replacement therapy of other hormones, if necessary, nutritional status, age at onset of therapy, GH dose and duration of therapy are some of these confounding factors. If GH therapy is given daily in adequate doses and started at younger ages the growth response will be beter. The prepubertal period is very important in obtaining a good growth response. In this paper, the effects of GH therapy on growth in different disorders in childhood and possible adverse effects will be reviewed with an evidence based approach.

Anahtar Kelimeler

Growth hormone, childhod, growth, adverse effect

Kaynakça

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