Çocuklarda Üst Solunum Yolu İnfeksiyonlarında 2006-2008 Dönemi Viral Etiyoloji Araştırması

Yıl 2008, Cilt: 8 Sayı: 3, 179 - 182, 01.07.2008

Emin Ünüvar Ş Seda Öz İsmail Yıldız Meral Çıplak Selim Badur Ayşe Kılıç Fatma Oğuz Müjgan Sıdal

Öz

Amaç: Çocuklarda üst solunum yolu infeksiyonlarının viral etiyolojisinin saptanması ve etkenlerin yıllara göre dağılımının gösterilmesi amaçlandı. Yöntem: Prospektif, klinik bu araştırma İstanbul Üniversitesi İstanbul Tıp Fakültesi Çocuk Sağlığı ve Hastalıkları Anabilim Dalı Polikliniğine 2006-2008 yılları arasında başvuran ve yaşları 1-180 ay olan 380 üst solunum yolu infeksiyonlu vaka ile yürütüldü. Vakaların klinik bulguları kaydedildikten sonra, nazal sürüntü örneği alındı ve 380 örnekte İnfluenza-A, B ve Respiratuar Sinsisyal Virüs araştırıldı. Bulgular: Nazal sürüntülerden virüs izole edebilme oranımız % 23.1’dir. En sık izole edilen virüsler sırasıyla influenza-A % 62.5 ve respiratuar sinsisyal virüs % 28.4 olarak saptandı. İnfluenza A tüm yaş gruplarında en yüksek oranda bulunan virustür. İnfluenza A izolasyon oranı yaşla artmaktadır 0-24 ay arasında % 51.5, 2-5 yaş arasında % 50, > 5 yaşta % 78.1 olarak influenza A virusu izole edildi . Sonuç: Çocuklarda üst solunum yolu infeksiyonlarında viral etiyoloji % 23.1 oranındadır ve en sık etken influenza tip A’dır

Anahtar Kelimeler

Üst solunum yolu infeksiyonu, çocuk, RSV, influenza

The Investigation of Viral Etiology in Children with Upper Respiratory Tract Infection Between the Years 2006 and 2008

Öz

Objectives: We aimed to detect the viral etiology of upper respiratory tract infections in children and the range of agents through years. Methods: This was a prospective clinical study done in Istanbul Unıversty, Faculty of Medicine. We studied with 380 children with upper respiratory tract infection whose ages were between 1 and 180 months and applied our department of pediatrics in 2006- 2008. After the clinical findings of the cases have been recorded nasal smear sampling was done and in 380 sample we search for influenza A-B and Respiratory syncytial viruses. Results: We isolated virus in 23.1 % percent of nasal smear samples. The most frequent viruses were found as influenza A 62.5 % and respiratory syncytial virus 28.4 % . Influenza A was the most common agent in all age groups. The isolation rate of influenza A was increased as the children get older We isolated influenza A virus in 51.5 % of 0-24 months oldchildren, 50 % of 2-5 years old children and 78.1 % of children older than 5 years . Conclusion: The viral etiology rate of upper respiratory tract infections in children is 23.1 % and the most common agent is influenza A.

Anahtar Kelimeler

Upper respiratory tract infection, child, RSV, influenza

Kaynakça

• Monto AS. Epidemiology of viral respiratory infections. Am Hall CB. Medical progress: respiratory syncytial virus and parainfluenza virus. N Engl J Med 2001; 344:1917-28.
• Glezen WP, Paredes A, Taber LH. Influenza in children: ralationship to other respiratory agents. JAMA 1980; :1345-9. patient visits and hospitalizations related to influenza in infants and young children. Pediatrics 2004; 113:585-93.
• Hemming VG. Viral respiratory diseases in children: classifi- cation, etiology, epidemiology, and rik factors. J Pediatr 1994; :513-6.
• Peters MF, van der Plas SM, Wilbrink B. A case-control study of acute respiratory tract infection in general practice patients in The Netherlands. Clin Infect Dis 2005; 41:490-7.
• Williams JV. The clinical presentation and outcomes of child- ren infected with newly identified respiratory tract viruses. Infect Dis Clin North Am 2005; 19:569-84.
• MR. The effect of influenza on hospitalizations, outpatient visits, and courses of antibiotics in children. N Engl J Med ; 342:225-31. Wesseligh S. Comparison of a multiplex revers transcription enzyme hybridization assay with conventional viral culture and immunofluorescense technique for the detection of seven viral respiratory pathogens. J Clin Microbiol 2001; 39:2779
• Morens MD. Influenza-related mortality. JAMA 2003; :227-9.
• Grijalva CG, Craig AS, Dupont WD, et al. Estimating inf- luenza hospitalizations among children. Emerg Infect Dis ; 12:103-9. :227-9 and the rates of hospitalization for respiratory disease among infants and young children. N Engl J Med 2000; 342:232-9.
• Poehling KA, Edwards KM, Weinberg GA, et al. The underrecognized burden of influenza in young children. N Engl J Med 2006; 355:31-40. versus nasopharyngeal aspirate for isolation of respiratory viruses. J Clin Microbiol 2002; 40:4337-9.
• Wesselingh S. Comparison of a multiplex revers transcription- PCR-enzyme hybridization assay with conventional viral culture and immunofluorescense technique for the detection of seven viral respiratory pathogens. J Clin Microbiol 2001; :2779-83.
• Influenza and respiratory syncytial virus morbidity among 19 aged group in Yunus Emre Health Center. Turk J Pediatr ; 47:316-22. tory syncytial virus, influenza and parainfluenza viruses to acute respiratory infections in San Luis Potosi, Mexico. Pediatr Infect Dis J 2005; 24:1049-52. BMJ 2006; 332:67. based surveillance for hospitalizations associated with respira- tory syncitial virus, influenza virus, and parainfluenza viruses among young children. Pediatrics 2004; 113:1758-64.