Yıl 2020, Cilt 20 , Sayı 3, Sayfalar 115 - 119 2020-12-29

GvHH Patogenezi ve Biyolojisi
Pathogenesis and Biology of Graft-Versus-Host Disease

Demet KIVANÇ [1] , Fatma Savran OĞUZ [2]


Graft versus host hastalığı (GvHH) genellikle hematopoetik kök hücre nakli (HKHN) sonrası gelişen ve nakil işleminin başarısını etkileyen önemli bir komplikasyondur. GvHH’nin iyi yönetilmesi, önlenmesi ve tedavi stratejilerinin geliştirilebilmesi için patogenezi, risk faktörleri, prognozu ve biyobelirteçlerinin tespit edilmesi önemlidir. Bu derlemede GvHH biyolojisinde etkili olan faktörlerden klasik ve klasik olmayan insan lökosit antijenleri (HLA) genleri, minör HLA antijenleri, sitokinler, kemokinler ve kostimülatör moleküller ile ilgili literatürde yer alan güncel çalışmalar sunulmuştur.

Graft-versus-host disease (GvHD) is an important complication that usually develops after hematopoietic stem cell transplantation and affects the success of the transplant. It is important to identify the pathogenesis, risk factors, prognosis, and biomarkers for the management and prevention of GvHD, as welll as the development of treatment strategies for GvHD. This review presents current literature studies on factors that affect GvHD biology, including classical and nonclassical human leukocyte antigen (HLA) genes, minor HLA antigens, cytokines, chemokines, and costimulatory molecules.

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Birincil Dil tr
Konular Pediatri
Bölüm Derlemeler
Yazarlar

Orcid: 0000-0002-2451-5709
Yazar: Demet KIVANÇ (Sorumlu Yazar)
Kurum: İSTANBUL ÜNİVERSİTESİ, İSTANBUL TIP FAKÜLTESİ
Ülke: Turkey


Orcid: 0000-0002-6018-8936
Yazar: Fatma Savran OĞUZ
Kurum: İSTANBUL ÜNİVERSİTESİ, İSTANBUL TIP FAKÜLTESİ
Ülke: Turkey


Tarihler

Yayımlanma Tarihi : 29 Aralık 2020

Bibtex @derleme { jchild780358, journal = {Çocuk Dergisi}, issn = {}, eissn = {1308-8491}, address = {Çocuk Dergisi Yayın Kurulu Sekreterliği İstanbul Tıp Fakültesi, Çocuk Sağlığı ve Hastalıkları Anabilim Dalı Çapa, 34390, İstanbul}, publisher = {İstanbul Üniversitesi}, year = {2020}, volume = {20}, pages = {115 - 119}, doi = {}, title = {GvHH Patogenezi ve Biyolojisi}, key = {cite}, author = {Kıvanç, Demet and Oğuz, Fatma Savran} }
APA Kıvanç, D , Oğuz, F . (2020). GvHH Patogenezi ve Biyolojisi . Çocuk Dergisi , 20 (3) , 115-119 . Retrieved from https://dergipark.org.tr/tr/pub/jchild/issue/58892/780358
MLA Kıvanç, D , Oğuz, F . "GvHH Patogenezi ve Biyolojisi" . Çocuk Dergisi 20 (2020 ): 115-119 <https://dergipark.org.tr/tr/pub/jchild/issue/58892/780358>
Chicago Kıvanç, D , Oğuz, F . "GvHH Patogenezi ve Biyolojisi". Çocuk Dergisi 20 (2020 ): 115-119
RIS TY - JOUR T1 - GvHH Patogenezi ve Biyolojisi AU - Demet Kıvanç , Fatma Savran Oğuz Y1 - 2020 PY - 2020 N1 - DO - T2 - Çocuk Dergisi JF - Journal JO - JOR SP - 115 EP - 119 VL - 20 IS - 3 SN - -1308-8491 M3 - UR - Y2 - 2020 ER -
EndNote %0 Çocuk Dergisi GvHH Patogenezi ve Biyolojisi %A Demet Kıvanç , Fatma Savran Oğuz %T GvHH Patogenezi ve Biyolojisi %D 2020 %J Çocuk Dergisi %P -1308-8491 %V 20 %N 3 %R %U
ISNAD Kıvanç, Demet , Oğuz, Fatma Savran . "GvHH Patogenezi ve Biyolojisi". Çocuk Dergisi 20 / 3 (Aralık 2020): 115-119 .
AMA Kıvanç D , Oğuz F . GvHH Patogenezi ve Biyolojisi. Çocuk Dergisi. 2020; 20(3): 115-119.
Vancouver Kıvanç D , Oğuz F . GvHH Patogenezi ve Biyolojisi. Çocuk Dergisi. 2020; 20(3): 115-119.
IEEE D. Kıvanç ve F. Oğuz , "GvHH Patogenezi ve Biyolojisi", Çocuk Dergisi, c. 20, sayı. 3, ss. 115-119, Ara. 2021