GvHH Patogenezi ve Biyolojisi

Demet Kıvanç; Fatma Savran Oğuz

Derleme

Pathogenesis and Biology of Graft-Versus-Host Disease

Yıl 2020, Cilt: 20 Sayı: 3, 115 - 119, 29.12.2020

Demet Kıvanç Fatma Savran Oğuz

Öz

Graft-versus-host disease (GvHD) is an important complication that usually develops after hematopoietic stem cell transplantation and affects the success of the transplant. It is important to identify the pathogenesis, risk factors, prognosis, and biomarkers for the management and prevention of GvHD, as welll as the development of treatment strategies for GvHD. This review presents current literature studies on factors that affect GvHD biology, including classical and nonclassical human leukocyte antigen (HLA) genes, minor HLA antigens, cytokines, chemokines, and costimulatory molecules.

Anahtar Kelimeler

Graft-versus-host disease, hematopoietic stem cell transplantation, human leukocyte antigens

Kaynakça

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