The Effect of Vitamin B12 Levels on Prognosis in COVID-19 Patients

Öz

Objectives: It is known that vitamins have some effects such as suppressing viral replication, developing anti-inflammatory responses and that they increase immunity in COVID-19. This study aimed to investigate the correlation between the vitamin B12 (Vit B12) serum levels and the prognosis of the disease in patients with COVID-19. Material and Method: A total of 408 participants were included in the study. Sociodemographic information such as age, educational status, serum vitamin B12 levels, hemogram parameters, and clinical findings of the patients who were admitted for follow-up after the end of COVID-19 infection was evaluated retrospectively. Serum vitamin B12 level between 150-200 pg/mL was assessed as mild deficiency, the value between 100-150 pg/mL as severe deficiency and the value under 100 pg/mL as extremely severe deficiency. Results: Median age of the participants was 44.51 (18-88) years. The median Vit B12 level of the patients was 179.50 (75-641). Of the patients, 248 (60.70%) had Vit B12 deficiency. The rates of pneumonia and hospitalization were higher and fatigue and loss of taste/smell were more in patients with Vit B12 deficiency. NLR and PLR which are the inflammatory markers were higher in patients with Vit B12 deficiency. The rates of pneumonia and hospitalization were the highest in the severe Vit B12 deficiency group among the Vit B12 deficiency groups. Conclusion: The clinical progression was worse in COVID-19 patients with Vit B12 deficiency than those who had no Vit B12 deficiency. Therefore, it has been concluded that Vitamin B12 supplement can have positive effects on COVID-19 patients; however, more comprehensive further studies with longer duration and higher number of patients are needed.

Anahtar Kelimeler

• COVID-19
• vitamin B12
• inflammation
• prognosis

COVID-19 Hastalarında Vitamin B12 Düzeyinin Prognoz Üzerine Etkisi

Öz

Amaç: Vitaminlerin, Koronavirüs Hastalığında (COVID-19) viral replikasyonu bozma, anti-inflamatuar yanıt geliştirme gibi etkileri olduğu ve immüniteyi artırdıkları bilinmektedir. Bu çalışmada, COVID-19 hastalarında Vitamin B12 (Vit B12) serum seviyeleri ve hastalığın prognozu arasındaki ilişkiyi görmeyi amaçladık. Gereç ve Yöntem: Çalışmaya COVID-19 enfeksiyonu geçiren 408 katılımcı dâhil edildi. Hastaların yaş, eğitim durumu gibi sosyodemografik bilgileri, serum Vit B12 düzeyleri, hemogram parametreleri, klinik bulguları retrospektif olarak incelendi. Serum B12 vitamini düzeyi 200-2000 normal, 150-200 pg/mL arası hafif eksiklik, 100-150 pg/mL arası ağır eksiklik 100 pg/mL’niın altı ise çok ağır eksiklik olarak gruplandırıldı. Bulgular: Katılımcıların yaş ortancası 44.51(18-88), Vit B12 düzeyi ortancası ise 179.50 ng/L (75-641) idi. Hastaların 248 (%60.78)’inde Vit B12 eksikliği vardı. Ağır Vit B12 eksikliği olan hastalarda ve çok ağır Vit B12 eksikliği olanlarda ateş, diğer gruplardan daha fazlaydı. Benzer şekilde öksürük, tat ve koku kaybı, baş ağrısı. pnömöni ve hospitalizasyon oranı daha yüksekti (P<0.01). Gruplar arasında platelet, nötrofil sayıları açısından anlamlı farklılık vardı. Vit B12 düzeyi normal oranlara göre hafif ve ağır Vit B12 düzeyi olan hastaların platetet sayısından daha yüksekti(p<0.01) Ağır Vit B12 eksikliği olanların nötrofil düzeyleri normal Vit B12 düzeyine sahip hastalardan daha yüksekti (p<0.01). Sonuç: Vit B12 düzeyi eksik olan COVID-19 hastalarının klinik progresyonunun Vit B12 eksikliği olmayanlardan daha kötü olduğu belirlendi. Bu nedenle COVID-19 hastalarında Vit B12 takviyesinin olumlu etkisi olabileceği, ancak bu konuda daha uzun süreli ve daha fazla hasta ile kapsamlı çalışmaların yapılması gerekmektedir.

Anahtar Kelimeler

• COVID-19
• vitamin B12
• inflamasyon
• prognoz

Kaynakça

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