CLINICAL IMPORTANCE OF C-REACTIVE PROTEIN TO ALBUMIN RATIO (CAR) IN COVID-19 PNEUMONIA

Öz

AIM The course of infection due to SARS-CoV-2 is manifested by viral replication in the upper respiratory tract with or without lung involvement and extrapulmonary systemic hyperinflammation syndrome. Because it has a wide clinical spectrum ranging from asymptomatic cases to multiorgan failure, early identification of prognostic biomarkers is crucial to distinguish patients at risk of developing more serious disease. Our aim is to investigate the relationship between the biomarker CAR, which has both prognostic and diagnostic importance, and Covid 19 infection. MATERİALS AND METHODS Between 1 June 2021 and 1 September 2021, 215 patients who were followed up in the pandemic service and intensive care unit for Covid 19 pneumonia were retrospectively analyzed. The demographic and routine laboratory data of the patients and the parameters accepted as new inflammatory biomarkers such as NLR, PLR, LMR and CAR were compared between the service-intensive care unit and exitus-discharged groups. RESULTS A total of 205 patients with a diagnosis of Covid 19 pneumonia, 113 (55.1%) male and 92 (44.9%) female, were included in the study. When CAR, known as a new inflammatory biomarker, was compared between both groups, it was found to be statistically significantly higher in patients hospitalized in the intensive care unit (p<0.001). In addition, this biomarker was shown to be significantly associated with mortality (p=0.001). The presence of HT and malignancy was found to be statistically significant in terms of the risk of hospitalization and mortality in the intensive care unit (p<0.001, p<0.001). CONCLUSION The CAR can be a reliable, inexpensive and easily accessible parameter that can be used both in clinical classification and in determining the prognosis in COVID 19 infection causing the pandemic.

Anahtar Kelimeler

• C-reactive protein
• albumin
• CAR
• COVI 19
• prognosis

COVİD 19 PNÖMONİSİNDE C-REAKTİF PROTEİN ALBUMİN ORANININ (CAR) KLİNİK ÖNEMİ

Öz

AMAÇ SARS-CoV-2’ye bağlı gelişen enfeksiyonun seyri, akciğer tutulumu olan veya olmayan üst solunum yollarında virüs çoğalması ve ekstrapulmoner sistemik hiperinflamasyon sendromu ile kendini gösterir. Asemptomatik vakalardan multiorgan yetmezliğine kadar değişen geniş bir klinik yelpazeye sahip olduğundan, prognostik biyobelirteçlerin erken tanımlanması, daha ciddi hastalık geliştirme riski olan hastaları ayırt etmek için çok önemlidir. Amacımız, hem prognostik hemde diagnostik önemi olan CAR adlı biyobelirtecin, Covid 19 enfeksiyonu ile ilişkisini araştırmaktır. GEREÇ VE YÖNTEM 1 haziran 2021 – 1 eylül 2021 tarihleri arasında pandemi servisi ve yoğun bakım ünitesinde Covid 19 pnömonisi nedeniyle takip edilmiş 215 hasta retrospektif olarak incelendi. Hastaların demografik ve rutin laboratuvar verileri ile NLR, PLR, LMR ve CAR gibi yeni inflamatuar biyobelirteçler olarak kabul edilen parametreler servis – yoğun bakımda yatanlar ve exitus – taburcu olan gruplar arasında karşılaştırıldı. BULGULAR Çalışmaya 113 (% 55.1)‘ü erkek, 92 (% 44.9)’si kadın olmak üzere toplam 205 Covid 19 pnömoni tanılı hasta dahil edildi. Yeni inflamatuar biyobelirteç olarak bilinen CAR, her iki grup arasında karşılaştırıldığında, yoğun bakımda yatan hastalarda istatiksel olarak anlamlı yüksek bulundu (p<0.001). Ayrıca bu biyobelirteçin mortalite ile anlamlı ilişkili olduğu gösterildi (p=0.001).Yoğun bakım yatış ve mortalite riski açısından HT ve malignite varlığı istatiksel olarak anlamlı bulundu (p<0.001, p<0.001 ). SONUÇ CAR, pandemiye neden olan COVİD 19 enfeksiyonunda hem klinik sınıflamada hemde prognozu belirlemede kullanılabilecek güvenilir, ucuz ve kolay ulaşılabilir bir parametre olabilir.

Anahtar Kelimeler

• C-raektif protein,
• albumin,
• CAR,
• COVİD 19,
• prognoz

Kaynakça

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