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COVID-19 Pnömonisi Sonrası AntiHBs Değerlerindeki Değişiklikler

Yıl 2022, , 537 - 542, 31.07.2022
https://doi.org/10.16899/jcm.1062780

Öz

Amaç: Coronavirus-19 hastalığı (COVID-19) sırasında antiHBS titresinin koruyucu değerin altına düşüp düşmediğini belirlemeyi amaçladık.
Gereç ve Yöntem: Son 1 yıl içinde pozitif antiHbs değerleri kontrol edilen 67 hasta ile prospektif bir çalışma yapıldı. Demografik veriler ve önceki antiHBs değerleri hasta dosyalarından toplandı ve COVID-19 enfeksiyonundan bir ay sonra kontrol edilen yeni antiHBs titrelerinin laboratuvar bulguları öncekilerle karşılaştırıldı.
Bulgular: COVID-19 sonrası yapılan değerlendirmede COVID-19 hastalarının antiHBs düzeylerinde COVID-19 enfeksiyonu öncesi önceki değerlere göre istatistiksel olarak anlamlı düşüş saptandı(p<0,001).
Sonuç: Çalışmamızda COVID-19 enfeksiyonu sonrası AntiHBs düzeylerinde istatistiksel olarak anlamlı bir düşüş olduğunu ancak bunun koruyucu antiHBs düzeyinin altında olmadığını gördük. Sonuç olarak COVID-19 enfeksiyonu sırasında veya sonrasında hepatit B'ye karşı güçlendirici aşıya gerek olmadığını söyleyebiliriz ancak hasta sayısı daha yüksek olan çalışmalarla desteklenmesi uygun olur.

Destekleyen Kurum

yok

Proje Numarası

reg: E- 48670771- 514.10

Kaynakça

  • 1. Horby P, Lim WS, Emberson JR, et al. Dexamethazone in Hospitalized patients with COVID-19-preliminary report. The new England Journal of Medicine. 2021 Feb25; 384(8):693704. PMID: 32678530 doi:10.1056/NEJMoa2021436.
  • 2. Koffas A, Dolman GE, Kennedy PTF. Hepatitis B virus reactivationin patients treated with immunesuppressive drugs: a practical guide for clinicians. Clin Med(Lond). 2018 Jun; 18(3):212-218. PMID: 29858430 doi: 10.7861/clinmedicine.18-3-212
  • 3. Lubel JS, Testro AG, Angus PW. Hepatitis B Virus reactivation following immunesuppressive therapy: guidelines for prevention and management. Intern Med J. 2007 Oct;37(10):705-12. PMID: 17894766 doi: 10.1111/j.1445-5994.2007.01479.x.
  • 4. Colson P, Borentain P, Coso D, et al. Hepatitis B virus reactivation inHbsAg negative patients is associated with emergence of viral strains with mutated HBsAg and reverse transcriptase. Virology, 2015oct, 484:354-363. PMID: 26186574 doi: 10.1016/j.virol.2015.06.017.
  • 5. Rodriguez-Tajes S, Miralpeix A, Costa J, et al. Low risk of hepatitis B reactivation in patients with severe COVID-19 who receive immunosuppressive therapy. J Viral Hepat. 2021 Jan 28(1):89-94. PMID: 32969557 doi:10.1111/jvh.13410.Epub 2020 dct 12.
  • 6. Perillo RP, Gish R, Falek-Ytter YT. American Gastroenterological Association Institute technical review on prevention and treatment of hepatitis B virus reactivation during immunosuppressive drug therapy. Gastroenterology.2015;148:221-44. PMID: 25447852 doi: 10.1053/j.gastro.2014.10-038
  • 7. Yalcin Kehribar D, Okuyucu M, Ozgen M, Ketenci YB, Ayyıldız T, Yıldırım B. Impact of tumor necrosis factor alpha antagonist treatment on antibody titer of hepatitis B surface antigen. J Surg Med. 2020; 4(8):678-681 doi:10.28982/josam.777871
  • 8. Cho Y, Yu SJ, Cho EJ, et al. High titers of anti-HBs prevent rituximab related viral reactivation in resolved hepatitis B patients with non-Hodgkin’s lymphoma. J Med Virol.2016 Jun;88(6):1010-7. PMID: 26531242 doi:10.1002/jmv.24423
  • 9. Tamori A, Koike T, Goto H, et al. Prospective study of reactivation of hepatitis B virus in patients with rheumatoid artrhritis who received immunosuppressive therapy, evaluation of both HBsAg positive and HBsAg negative cohorts. J Gastroenterol.2011;46:556-64. PMID: 21246383 doi: 10.1007/s00535-010-0367-5
  • 10. Vassilopoulos D, Apostokopoulou A, Hadziyannis E, et al. Long term safety of anti-TNF treatment in patients with rheumatic diseases and chronic or resolved hepatitis B virus infection. Ann Rheum Dis.2010;69:1352-5. PMID: 20472596 doi: 10.1136/ard.2009.127233
  • 11. Guglielmo D, Alessandra Toletone A, Barberis I, et al. Persistance of protective anti-HBs antibody levels and amnestic response to HBV booster. Vaccination: A cross-sectional study among healthcare students 20 years following in Italy. Hum vaccine Immunother.2017 Feb;13(2):440-444. PMID: 27925503 doi:10.1080/21645515.2017.1264788.

The Changes In The AntiHBs Values Following COVID-19 Pneumonia

Yıl 2022, , 537 - 542, 31.07.2022
https://doi.org/10.16899/jcm.1062780

Öz

Background/aim: We aimed to determine if there is a decrease in antiHBS titer below the protective value during Coronavirus-19 disease (COVID-19).
Materials and methods: A prospective study was made of 67 patients who had positive antiHbs values checked in the last 1 year. Demographic data and the previous antiHBs values were collected from the patient files and the laboratory findings of new antiHBs titers checked after one months later following COVID-19 infection were compared with the previous ones.
Results: In the postcovid evaluation, a statistically significant decrease in the antiHBs levels of COVID-19 patients was determined with respect to previous values before COVID-19 infection (p<0,001).
Conclusion: In our study, we found that there was a statistically significant decrease in AntiHBs levels after COVID-19 infection, but none of them were below protective antiHBs levels. As a result, we can say a booster vaccination against hepatitis B is not needed during or after COVID-19 infection, but it would be appropriate to support it with studies with a higher number of patients.

Proje Numarası

reg: E- 48670771- 514.10

Kaynakça

  • 1. Horby P, Lim WS, Emberson JR, et al. Dexamethazone in Hospitalized patients with COVID-19-preliminary report. The new England Journal of Medicine. 2021 Feb25; 384(8):693704. PMID: 32678530 doi:10.1056/NEJMoa2021436.
  • 2. Koffas A, Dolman GE, Kennedy PTF. Hepatitis B virus reactivationin patients treated with immunesuppressive drugs: a practical guide for clinicians. Clin Med(Lond). 2018 Jun; 18(3):212-218. PMID: 29858430 doi: 10.7861/clinmedicine.18-3-212
  • 3. Lubel JS, Testro AG, Angus PW. Hepatitis B Virus reactivation following immunesuppressive therapy: guidelines for prevention and management. Intern Med J. 2007 Oct;37(10):705-12. PMID: 17894766 doi: 10.1111/j.1445-5994.2007.01479.x.
  • 4. Colson P, Borentain P, Coso D, et al. Hepatitis B virus reactivation inHbsAg negative patients is associated with emergence of viral strains with mutated HBsAg and reverse transcriptase. Virology, 2015oct, 484:354-363. PMID: 26186574 doi: 10.1016/j.virol.2015.06.017.
  • 5. Rodriguez-Tajes S, Miralpeix A, Costa J, et al. Low risk of hepatitis B reactivation in patients with severe COVID-19 who receive immunosuppressive therapy. J Viral Hepat. 2021 Jan 28(1):89-94. PMID: 32969557 doi:10.1111/jvh.13410.Epub 2020 dct 12.
  • 6. Perillo RP, Gish R, Falek-Ytter YT. American Gastroenterological Association Institute technical review on prevention and treatment of hepatitis B virus reactivation during immunosuppressive drug therapy. Gastroenterology.2015;148:221-44. PMID: 25447852 doi: 10.1053/j.gastro.2014.10-038
  • 7. Yalcin Kehribar D, Okuyucu M, Ozgen M, Ketenci YB, Ayyıldız T, Yıldırım B. Impact of tumor necrosis factor alpha antagonist treatment on antibody titer of hepatitis B surface antigen. J Surg Med. 2020; 4(8):678-681 doi:10.28982/josam.777871
  • 8. Cho Y, Yu SJ, Cho EJ, et al. High titers of anti-HBs prevent rituximab related viral reactivation in resolved hepatitis B patients with non-Hodgkin’s lymphoma. J Med Virol.2016 Jun;88(6):1010-7. PMID: 26531242 doi:10.1002/jmv.24423
  • 9. Tamori A, Koike T, Goto H, et al. Prospective study of reactivation of hepatitis B virus in patients with rheumatoid artrhritis who received immunosuppressive therapy, evaluation of both HBsAg positive and HBsAg negative cohorts. J Gastroenterol.2011;46:556-64. PMID: 21246383 doi: 10.1007/s00535-010-0367-5
  • 10. Vassilopoulos D, Apostokopoulou A, Hadziyannis E, et al. Long term safety of anti-TNF treatment in patients with rheumatic diseases and chronic or resolved hepatitis B virus infection. Ann Rheum Dis.2010;69:1352-5. PMID: 20472596 doi: 10.1136/ard.2009.127233
  • 11. Guglielmo D, Alessandra Toletone A, Barberis I, et al. Persistance of protective anti-HBs antibody levels and amnestic response to HBV booster. Vaccination: A cross-sectional study among healthcare students 20 years following in Italy. Hum vaccine Immunother.2017 Feb;13(2):440-444. PMID: 27925503 doi:10.1080/21645515.2017.1264788.
Toplam 11 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Kurumları Yönetimi
Bölüm Orjinal Araştırma
Yazarlar

Perihan Özkan Gümüşkaya 0000-0003-1810-7490

Özgür Altun 0000-0003-1810-7490

Nur Karakütük Yüztaş 0000-0002-8274-7014

Neslihan Özsoy 0000-0001-8660-1648

Gülten Aydın Tutak 0000-0003-4167-0564

Emine Yıldırım 0000-0003-2733-402X

Mine Adaş 0000-0003-3008-6581

Mehmet Küçük 0000-0003-1720-3819

Proje Numarası reg: E- 48670771- 514.10
Yayımlanma Tarihi 31 Temmuz 2022
Kabul Tarihi 29 Mayıs 2022
Yayımlandığı Sayı Yıl 2022

Kaynak Göster

AMA Özkan Gümüşkaya P, Altun Ö, Karakütük Yüztaş N, Özsoy N, Aydın Tutak G, Yıldırım E, Adaş M, Küçük M. The Changes In The AntiHBs Values Following COVID-19 Pneumonia. J Contemp Med. Temmuz 2022;12(4):537-542. doi:10.16899/jcm.1062780