Genitoüriner Tümörlerde Apelin/APJ ve Fibronektin Ekspresyonunun Değerlendirilmesi: Bir İmmünohistokimyasal Analiz

Öz

Amaç: Kanser, dünya genelindeki ölüm nedenleri arasında önde gelen bir durum olup, kanser araştırmaları ve yeni tedavi yöntemlerinin geliştirilmesi ciddi önem arz etmektedir. Mesane, endometrium ve prostat kanserleri, en yaygın kanser türleri arasında yer almaktadır. Bu çalışma, bu genitouriner tümörlerdeki endojen apelin/APJ reseptörü ve fibronektin ekspresyonunu ve dağılımını araştırmayı ve elde ettiği verileri benign dokularla karşılaştırarak literatüre katkı sunmayı amaçlamıştır. Gereç ve Yöntem: Endometrium, prostat ve mesaneye ait formalin ile fikse parafine gömülü benign ve malign dokularını içeren 44 vakaya immünohistokimyasal analiz uygulanmıştır. Bulgular: Endometrioid adenokarsinom, ürotelyal karsinom ve prostat adenokarsinomunda apelin, APJ ve fibronektin ekspresyonunda benign dokulara kıyasla önemli bir artış olduğu saptanmıştır. Ayrıca, bu tümörlerde bu moleküllerin ekspresyonu birbirleriyle doğrudan bir ilişki sergilemiştir. Bununla birlikte, prostat adenokarsinomunda ve endometrioid adenokarsinomunda tümör derecesi arttıkça, bu moleküllerin ekspresyonu azalmıştır. Sonuç: Bu çalışma, literatürde genitouriner tümörlerdeki endojen apelin/APJ reseptörü ve fibronektin ekspresyonunun ve dağılımının histolojik olarak benign karşılıklarıyla kıyaslandığı ilk çalışmadır. Elde edilen bulguların, apelin/APJ reseptörü ve fibronektinin tümorigenez ve kanser tedavilerindeki potansiyel rolleri açısından planlanacak daha ileri araştırmalar için bir temel oluşturacağı kanısındayız.

Anahtar Kelimeler

• Apelin
• APJ
• mesane karsinomu
• endometrial karsinom
• fibronektin
• genitouriner tümörler
• immünohistokimya
• prostat karsinomu

Evaluation of Apelin/APJ and Fibronectin Expression in Genitourinary Tumors: An Immunohistochemical Analysis

Öz

Background/Aims: Cancer is a leading cause of death worldwide, making cancer research and the development of new treatment methods crucial. Bladder, endometrial, and prostate cancers are among the most prevalent forms of cancer. This study aimed to investigate the expression and distribution of endogenous apelin/APJ receptor and fibronectin in these genitourinary tumors and compare them to benign tissues to contribute new data to the literature. Material and Method: Immunohistochemical methods were applied to 44 cases, including benign and malignant formalin-fixed paraffin-embedded tissues of the endometrium, prostate, and bladder. Results: The findings showed a significant increase in apelin, APJ, and fibronectin expression in endometrioid adenocarcinoma, urothelial carcinoma, and prostatic adenocarcinoma compared to benign tissues. Moreover, the expression of these molecules had a direct correlation with each other in these tumors. However, in prostatic adenocarcinoma and endometrioid adenocarcinoma, as the tumor grade increased, the expression of these molecules decreased. Conclusions: This is the first study to examine the co-expression and distribution of endogenous apelin/APJ receptors and fibronectin in genitourinary tumors and compare them histologically with benign counterparts, to the best of our knowledge. This underscores the novelty and significance of our findings, providing a foundation for further exploration of the potential roles of these molecules in tumorigenesis and cancer therapies.

Anahtar Kelimeler

• Apelin
• APJ
• bladder carcinoma
• endometrial carcinoma
• fibronectin
• genitourinary tumors
• immunohistochemistry
• prostate carcinoma

Kaynakça

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