MEME KARSİNOMLARINDA TOLL-LİKE RESEPTÖR 9 EKSPRESYONUNUN PROGNOZLA İLİŞKİSİ

Öz

Amaç: Meme kanseri (MK) kadınlarda sık görülen bir malignitedir. Toll-like reseptör 9 (TLR9) dahil bazı moleküller, MK'de potansiyel prognostik faktörler olarak halen araştırılmaktadır. Bu çalışmada, MK'de TLR9 ekspresyonu ile klinikopatolojik prognostik parametreler ve sağkalım arasındaki ilişkiyi belirlemeyi amaçladık. Gereç ve Yöntem: Bu çalışmaya BC tanısı konulan 139 hasta dahil edildi. Doku TLR9 ekspresyon seviyelerini ortaya koymak için immüno-reaktivite skorlama (IRS) sistemi kullanıldı. Bulgular: İnvaziv karsinom NOS tanısı alan tümörlerde, derece 3 tümörlerde, nekrozlu tümörlerde, Östrojen reseptörü (ER) negatif ve Human epidermal growth factor 2 (Her2) pozitif tümörlerde ve üçlü negatif moleküler alt tipte daha yüksek TLR9 ekspresyonu bulduk. Ayrıca, TLR9 skorları düşük olan tümörler, yüksek TLR9 skorları olan tümörlere kıyasla daha yüksek genel sağkalım göstermiştir. Sonuç: MK'de TLR9 aşırı ekspresyonu, genel sağkalımın yanı sıra histolojik tip, tümör derecesi, tümör nekrozu, ER ve Her2 durumu ve moleküler alt tip gibi bazı prognostik parametrelerle ilişkilidir. TLR9'un MK'de klinik ve terapötik bir hedef olarak kullanımına ışık tutmak için daha geniş hasta serileri ile daha fazla çalışmaya ihtiyaç vardır.

Anahtar Kelimeler

• meme kanseri
• patoloji
• TLR9
• immunohistokimya
• prognoz

ASSOCIATION OF TOLL-LIKE RECEPTOR 9 EXPRESSION WITH PROGNOSIS IN BREAST CARCINOMA

Öz

Aim: Breast cancer (BC) is a common malignancy in women. Some molecules including TLR9 are still under investigation as potential prognostic factors in BC. In the present study, we aimed to determine the relation between TLR9 expression and clinicopathological prognostic parameters and survival in BC. Materials and methods: One hundred and thirty nine patients diagnosed as BC included the present study. Immuno-reactivity scoring (IRS) system was used to reveal the tissue TLR9 expression levels. Results: We found higher TLR9 expression in tumors diagnosed as invasive carcinoma NOS, grade 3 tumors, tumors with necrosis, ER negative and Her2 positive tumors and tripple negative molecular subtype. Furthermore, tumors with low TLR9 scores showed increased overall survival compared to tumors with high TLR9 scores. Conclusions: TLR9 overexpression in BC is associated with some prognostic parameters including histologic type, tumor grade, tumor necrosis, ER and Her2 status and molecular subtype as well as overall survival. Further studies with larger patient series are needed to shed light on the use of TLR9 as a clinical and therapeutic target in BC.

Anahtar Kelimeler

• breast cancer
• pathology
• TLR9
• İmmunohistochemistry
• prognosis

Kaynakça

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