Fecal Calprotectin At The Time Of Diagnosis May Indicate The Presence Of Complications In Inflammatory Bowel Disease

Öz

Aim: We aimed to investigate the relationship between the presence of complications at the time of diagnosis or during follow-up and fecal calprotectin in patients with inflammatory bowel disease. Materials and Methods: Fecal calprotectin level was studied by the chromatographic lateral flow immunoassay method. Results: A total of 76 patients, 26 (34%) with Crohn's disease and 50 (66%) with ulcerative colitis, were included in the study. At the time of diagnosis and during follow-up, complications were observed in 17 (22%) and 20 (26%) patients, respectively. At the time of diagnosis, fecal calprotectin level was low (<50 mg/kg) in 26 (34%) patients, borderline (50-100 mg/kg) in 16 (21%) patients, and high (>100 mg/kg) in 34 (45%) patients. Hemoglobin and albumin levels were lower (p=0.013, p=0.012, respectively), and platelet count, eryrocyte sedimentation rate, and C-reactive protein levels were higher (p<0.001, p=0.004, p<0.001, respectively) in patients with high fecal calprotectin level than patients with low fecal calprotectin level. At the time of diagnosis and during follow-up, complications were higher in patients with high fecal calprotectin level than patients with low and borderline fecal calprotectin levels (p=0.001). The risk of developing complications was found to be 26 times higher at the time of diagnosis in patients with fecal calprotectin level >100 µg/g than patients with fecal calprotectin level below this value and 8 times higher during follow-up (p=0.006, p=0.015, respectively). Conclusion: The use of fecal calprotectin level together with tests showing acute inflammation in inflammatory bowel disease may predict the development of complications.

Anahtar Kelimeler

• Fecal calprotectin
• inflammatory bowel disease
• complications
• acute phase reactants

İnflamatuvar Bağırsak Hastalığında Tanı Anındaki Fekal Kalprotektin Komplikasyon Varlığını Gösterebilir

Öz

Amaç: İnflamatuvar bağırsak hastalığı olan hastalarda tanı anında ya da takip esnasındaki komplikasyon varlığı ile fekal kalprotektin arasındaki ilişkiyi değerlendirmeyi amaçladık. Gereç ve Yöntemler: Fekal kalprotektin düzeyi, kromatografik lateral akım immünoassay metodu ile çalışıldı Bulgular: Çalışmaya 26’sı (%34) Crohn’s hastalığı ve 50’si (%66) ülseratif kolit olan toplam 76 hasta alındı. Tanı anı ve takip sırasında hastaların sırasıyla 17 (%22) ve 20’sinde (%26) komplikasyon gözlendi. Tanı anında fekal kalprotektin düzeyi 26 (%34) hastada düşük (<50 mg/kg), 16 (%21) hastada sınırda (50-100 mg/kg) ve 34 (%45) hastada yüksek (>100 mg/kg) idi. Fekal kalprotektin düzeyi yüksek olan hastalarda düşük olan hastalara göre hemoglobin ve albümin düzeyleri daha düşük (sırasıyla, p=0.013, p=0.012), trombosit, eritrosit sedimentasyon hızı ve C-reaktif protein düzeyleri daha yüksekti (sırasıyla, p<0.001, p=0.004, p<0.001). Hastaların tanı anı ve takipleri sırasında komplikasyon varlığı fekal kalprotektin düzeyi yüksek olanlarda, düşük ve sınırda olanlara göre daha yüksek oranda olduğu gözlendi (p=0.001). Fekal kalprotektin düzeyi >100 mg/kg olan hastalarda bu değerin altında olan hastalara göre tanı anında komplikasyon gelişme riskinin 26 kat, takip esnasında ise 8 kat daha yüksek olduğu tespit edildi (sırasıyla, p=0.006, p=0.015). Sonuç: İnflamatuvar bağırsak hastalığında akut inflamasyonu gösteren tetkiklerle birlikte fekal kalprotektin düzeyinin kullanılması komplikasyon gelişimini öngörebilir.

Anahtar Kelimeler

• Fekal kalprotektin
• inflamatuvar bağırsak hastalığı
• komplikasyonlar
• akut faz reaktanları

Kaynakça

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