Primer Vezikoüreteral Reflü Profilaksisinde Amoksisilinin Uzun Dönem Etkinliğinin Değerlendirilmesi

Öz

Amaç: Vezikoüreteral reflü (VUR)’un konservatif tedavisinde antibiyotik profilaksisi uzun zamandan beri kullanılmaktadır. Bu çalışmada antibiyotik profilaksis olarak amoksisilinin uzun dönem etkinliği araştırıldı. Gereç ve Yöntem: VUR tanısı ile takip edilen ve en az 6 ay ve daha uzun süre amoksisilin profilaksisi alan hastaların klinik özellikleri ve izlem sonuçları retrospektif olarak araştırıldı. Bulgular: Çalışmaya 13’ü kız (%29.5), 31’i erkek (%70.5) olmak üzere 44 hasta alındı ve yaş ortalaması 2.9±1.3 aydı. Ortalama 27.4±19.4 ay takipte 9 hastada (%20.5) bir kez idrar yolu enfeksiyonu (İYE) ve 2 hastada (%4.5) ateşli İYE tespit edildi. İki hasta ateşli İYE, 2 hastada ise gastrointestinal yan etkiler olmak üzere toplam 4 hastada (%9) antibiyotik revizyonu yapıldı. Sonuç: VUR’lu hastaların amoksisilin profilaksisi ile uzun dönem takibi etkili ve güvenilir bir tedavi seçeneğidir.

Anahtar Kelimeler

• vezikoüreteral reflü
• idrar yolu enfeksiyonu
• amoksisilin

Long-term Effectiveness of Amoxicillin Prophylaxis for Children with Primary Vesicoureteral Reflux

Öz

Aim: The use of antibiotic prophylaxis in the conservative treatment of vesicoureteral reflux (VUR) has a long historical precedent. In this study, we investigated the long-term efficacy of amoxicillin as antibiotic prophylaxis. Materials and Methods: A retrospective investigation was conducted to examine the clinical characteristics and follow-up results of patients with VUR who received amoxicillin prophylaxis for at least of six months. Results: A total of 44 patients were included in the study, comprising 13 girls (29.5%) and 31 boys (70.5%), with a mean age of 2.9±1.3 months. During a mean follow-up period of 27.4±19.4 months, nine patients (20.5%) experienced one urinary tract infection (UTI), while two patients (4.5%) had a febrile UTI. Antibiotic revision was performed in a total of four patients (9%), including two patients with a febrile UTI and two patients with gastrointestinal side effects. Conclusion: The long-term follow-up of patients with VUR who have been treated with amoxicillin prophylaxis has demonstrated that this is an effective and safe treatment option.

Anahtar Kelimeler

• vesicoureteral reflux
• urinary tract infection
• amoxicillin

Kaynakça

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