ASTIM VE OBEZİTE

Öz

Abstract

 Son yıllarda dünyada hem obezite hem de astım görülme sıklığı artmıştır. Her iki hastalığın birlikte artış göstermesi obezitenin mekanik etkisi, inflamasyon, oksidatif stres, genetik ve epigenetik faktörler, yaşam tarzı ve çevresel maruziyetler gibi birtakım ortak mekanizmalar ile açıklanmaya çalışılmaktadır. Obezitenin eşlik ettiği astımda semptomlar daha şiddetlidir, atak nedeni ile hastaneye yatış sıklığı artmıştır ve tedaviye cevap alınması güçtür. Ayrıca astım tedavilerinin pek çok yan etkisi vardır. Obezite ve astım arasındaki ilişki mekanizmalarının netleşmesi ile yeni tedavi yaklaşımları ortaya konmuştur. Diyet ve egzersiz ile obez astımlıların klinik seyrinin iyileştiği gösterilmiştir. Obezite cerrahisi ile olumlu sonuçlar bildirilmektedir. Metabolik sendromun eşlik ettiği hastalarda metformin ve statinlerin fayda sağladığını gösteren çalışmalar vardır. Antioksidan içeren diyetlerin de astım kontrolünde yararı vardır. Ancak bu tedavi seçeneklerine yönelik daha kapsamlı çalışmalara ihtiyaç duyulmaktadır.

Anahtar Kelimeler

• astım,obezite

Kaynakça

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