The relation of chronic idiopathic urticaria with Fibromyalgia, sleep disturbance and anxiety

Öz

Aim: Fibromyalgia syndrome (FMS) and chronic idiopathic urticaria (CIU) are closely related due to peripheral neurogenic inflammation (neuropeptide secretion), immune dysfunction, and somatic complaints such as fatigue, pain, anxiety, and sleep disturbance. This study aimed to reveal the relationship of CIU with FMS, sleep disturbance and anxiety.

Materials and Methods: A total of 51 patients with CIU aged 18–64 years (36.2±10.4) and 45 sex- and age-matched healthy controls were included. Urticaria activity score (UAS) was assessed for the severity of urticaria.  The 2010 American College of Rheumatology classification criteria were used for FMS diagnosis. The participants were evaluated with visual analog scale (VAS), fibromyalgia impact questionnaire (FIQ), Pittsburgh sleep quality index (PSQI), and Beck anxiety inventory (BAI).

Results: The presence of FMS and body mass index (BMI) were significantly higher in the urticaria group compared with the control group. The mean FIQ and UAS of the urticaria group were 47.0 ± 22.1 and 1.3 ± 0.9, respectively.  UAS was positively correlated with FIQ, PSQI, BAI and VAS (rho=0.411 p=0.004; rho=0.310 p=0.034; rho=0.419 p=0.004; rho=0.414 p=0.004; respectively).  The presence of FMS was found to be significantly associated with high BMI (p = 0.04).

Conclusions: The prevalence of FMS was higher in patients with CIU than control group. Also, FMS was more severe, general pain and fatigue, sleep disturbance and anxiety were higher in patients with high urticarial activity. 

Anahtar Kelimeler

• Anxiety disorder,fibromyalgia syndrome,sleep disturbance,urticaria

Kronik idiopatik ürtiker ile Fibromyalji, uyku bozukluğu ve anksiyete ilişkisi

Öz

Amaç: Fibromiyalji sendromu (FMS) ve kronik idiyopatik ürtiker (CIU), periferik nörojenik inflamasyon (nöropeptid salınımı), immün işlev bozukluğu ve yaygın halsizlik, ağrı, anksiyete ve uyku bozukluğu gibi somatik şikayet nedeniyle yakından ilişkilidir. Bu çalışmada CIU ile FMS, uyku bozukluğu ve anksiyete ilişkisini ortaya koymak amaçlandı.

Gereç ve Yöntem: Yaşları 18-64 arasında değişen (36.2 ± 10.4) CIU'lu 51 hasta ile cinsiyet ve yaşa uygun 45 sağlıklı kontrol alındı. Ürtiker aktivite skoru (UAS) ürtiker şiddeti açısından değerlendirildi. FMS tanısı için 2010 Amerikan Romatoloji Cemiyeti sınıflandırma kriterleri kullanılmıştır. Katılımcılar görsel analog skala (VAS), fibromiyalji etkisi anketi (FIQ), Pittsburgh uyku kalitesi indeksi (PSQI) ve Beck anksiyete envanteri (BAI) ile değerlendirildi.

 

Bulgular: Ürtiker grubunda FMS ve vücut kütle indeksi (VKİ) kontrol grubuna göre anlamlı derecede yüksekti. Ürtiker grubunun FIQ ve UAS ortalaması sırasıyla 47.0 ± 22.1 ve 1.3 ± 0.9 idi. UAS ile FIQ, PSQI, BAI ve VAS pozitif korele idi (rho=0.411 p=0.004; rho=0.310 p=0.034; rho=0.419 p=0.004; rho=0.414 p=0.004; sırasıyla). FMS varlığı VKİ ile anlamlı ilişkiliydi (p = 0.04).

Sonuç: FMS prevalansı kontrol grubuna göre CIU olan hastalarda daha yüksekti. Ayrıca, yüksek ürtikeryel aktivite gösteren kişilerde FMS daha şiddetli, genel ağrı ve yorgunluk, uyku bozukluğu ve anksiyete daha yüksek idi. 

Anahtar Kelimeler

• Anksiyete bozukluğu,fibromyalji sendromu,uyku bozukluğu,ürtiker

Kaynakça

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