SARS, MERS ve COVID-19 Üzerine Karşılaştırmalı Bir Analiz

Öz

Şiddetli Akut Solunum Sendromu 2 (SARS-CoV-2 / COVID-19), şimdiden olmasa da yüzyılın pandemisi olma yolunda ilerliyor. Bir koronavirüs olarak, özellikle bağışıklık sistemi zayıflamış olanlar için ciddi solunum yolu hastalığına neden olduğu bilinmektedir. Şiddetli Akut Solunum Sendromu (SARS-CoV) ve Orta Doğu Solunum Sendromu (MERS-CoV), birçok ülkede binlerce kişiyi enfekte eden geçmiş koronavirüslerin en dikkate değer olanlarıdır. Üç virüs de zoonotik bir kökene sahip, ağırlıklı olarak koronavirüsün doğal rezervuar konaklarından biri olan yarasalardan gelmektedir. Bu nedenle, bu makalenin amacı, üç koronavirüsün de niteliklerini ve özelliklerini karşılaştırmaktır. SARS-CoV, MERS-CoV ve COVID-19, benzer sınıflandırmalarından dolayı birçok viral benzerliği paylaşırken, genetik olarak yakından ilişkili değillerdir. COVID-19, genomunun yaklaşık% 79'unu SARS-COV ile ve sadece yaklaşık% 50'sini MERS-CoV ile paylaşır. SARS-CoV ve SARS-CoV-2 arasındaki en önemli genetik benzerliklerden biri, paylaşılan reseptör proteinleri ACE2'dir. Her üç virüs de aynı baskın insandan insana bulaşma modunu paylaşsa da, solunum damlacıkları, SARS-CoV-2 diğer ikisinden çok daha yüksek bir enfeksiyon oranına sahiptir. Aerosol ve asimptotik iletim, COVID-19'un patlayıcı bulaşıcılığı için önde gelen bir faktör olabilir. Şu anda, sosyal mesafe, etkili bir aşı geliştirilinceye kadar COVID-19 ile mücadele için tek etkili önleyici stratejidir. Bir nükleotid analog ilaç olan Remdesivir, hastalar için iyileşme süresini kısaltmada pozitiflik gösteriyor. Nekahet plazma tedavisi tedavisi de bazı kritik hastalarda ümit verici bir iyileşme göstermiştir.

Anahtar Kelimeler

• SARS-CoV
• MERS-CoV
• COVID-19
• Koronavirüs
• Aşı
• Sosyal Uzaklaşma
• Remdesivir

A Comparative Analysis on SARS, MERS and COVID-19

Öz

The Severe Acute Respiratory Syndrome 2 (SARS-CoV-2/ COVID-19) is on its way to become the pandemic of the century, if not already. As a coronavirus, it is known to cause severe respiratory illness, especially for those with compromised immune systems. The Severe Acute Respiratory Syndrome (SARS-CoV) and The Middle East Respiratory Syndrome (MERS-CoV) are the most notable of past coronaviruses infecting thousands in numerous countries. All three viruses are from a zoonotic origin predominantly from bats, one of the coronavirus’s natural reservoir hosts. Therefore, the purpose of this article is to compare and contrast the attributes and features of all three coronaviruses. While SARS-CoV, MERS-CoV, and COVID-19 share many viral similarities due to their similar classification, they are not as closely related genetically. COVID-19 shares about 79% of its genome with SARS-COV and only about 50% with MERS-CoV. One of the most notable genetic similarities between SARS-CoV and SARS-CoV-2 is their shared receptor protein, ACE2. Although all three viruses share the same dominant mode of human-to-human transmission, respiratory droplets, SARS-CoV-2 seems to have drastically higher infection rates than the other two. Aerosol and asymptotic transmission could be a leading factor for COVID-19’s explosive infectivity. Currently, social distancing seems to be the only effective preventive strategy to tackle COVID-19.

Anahtar Kelimeler

• SARS-CoV
• MERS-CoV
• COVID-19
• Coronavirus
• Vaccine
• Social distancing

Kaynakça

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