Investigation of Seroprevalence of Hepatitis B, Hepatitis C and HIV in Hemodialysis Patients

Öz

Aim: Impairments in the immune system of patients undergoing HD cause patients to be more sensitive to infection agents. The purpose of this study; to determine the seroprevalance of HBV, HCV and HIV in patients undergoing hemodialysis treatment. Materials and Methods: HBsAg, Anti-HBs, Anti-HBc IgM, Anti-HBc IgG, HBV-DNA, Anti-HCV, HCV-RNA and Anti-HIV parameters studied from serum samples of Chronic Kidney Patients (CKD) undergoing hemodialysis treatment at Selçuk University Faculty of Medicine It has been scanned retrospectively for ten years. Results: HBsAg was determined in 17 (0.40%) of 4155 hemodialysis patients and Anti-HBs was positive in 454 (11.2%). Anti-HCV was detected as positive in 14 (0.33%) serum. HBV-DNA was found to be positive in 13 (76.5%) of HBsAg positive HD patients and in 12 (85.7%) of Anti-HCV positive patients. Anti-HIV antibodies were not detected in any of the serum samples. Conclusions: The results of our study have shown that proper infection control measures in hemodialysis patients can reduce the contamination of infectious agents. In addition, factors such as vaccination scheme, inoculation site and dose should be selected appropriately, taking into account the immunosuppressive state of the patients.

Anahtar Kelimeler

• Hemodialysis
• Chronic Kidney Patients
• Hepatitis B
• Hepatitis C
• HIV

Hemodiyaliz Hastalarında Hepatit B, Hepatit C ve HIV Seroprevalansının Araştırılması

Öz

Amaç: Hemodiyaliz (HD) uygulanan hastaların bağışıklık sistemindeki bozulmalar, hastaların enfeksiyon ajanlarına daha duyarlı olmasına neden olur. Bu çalışmanın amacı; hemodiyaliz tedavisi gören hastalarda HBV, HCV ve HIV seroprevalansını belirlemek olmuştur. Gereç ve Yöntem: Selçuk Üniversitesi Tıp Fakültesin’de hemodiyaliz tedavisi gören Kronik Böbrek Hastalarının (KBH) serum örneklerinden çalışılmış HBsAg, Anti-HBs, Anti-HBc IgM, Anti-HBc IgG, HBV-DNA, Anti-HCV, HCV-.RNA ve Anti-HIV parametrleri on yıl boyunca retrospektif olarak taranmıştır. Bulgular: 4155 hemodiyaliz hastasının 17'sinde (% 0,40) HBsAg ve 454'ünde ise (% 11,2) Anti-HBs pozitif bulunmuştur. Anti-HCV 14 (% 0.33) hastanın serumunda pozitift olarak saptanmıştır. HBsAg pozitif HD hastalarının 13'ünde (% 76,5) HBV-DNA ve Anti-HCV pozitif hastaların 12'sinde (% 85,7) HCV RNA pozitift olarak belirlenmiştir. Serum örneklerinin hiçbirinde anti-HIV antikorları tespit edilmemiştir. Sonuç: Çalışma sonuçları, hemodiyaliz hastalarında uygun enfeksiyon kontrol önlemlerinin bulaşıcı ajanların kontaminasyonunu azaltabileceğini göstermiştir. Ayrıca, aşılama şeması, aşılama yeri ve doz gibi faktörler, hastaların immünosupresif durumu dikkate alınarak uygun şekilde seçilmelidir.

Anahtar Kelimeler

• Hemodiyaliz
• Kronik Böbrek Hastalığı
• Hepatit B
• Hepatit C
• HIV

Kaynakça

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