Akut Pankreatitte Monosit Dağıtım Genişliğinin (MDW) Prognostik Değeri Var Mıdır? Bir Ön Çalışma

Öz

Amaç: Akut pankreatit, ileri evrelerde ölümcül olabilen yaygın bir hastalıktır. Bu nedenle, akut pankreatit prognozunun erken değerlendirilmesi önemlidir. Bu çalışmanın amacı, akut pankreatit prognozunun tanımlanmasında monosit dağılım genişliğinin önemini değerlendirmektir. Gereç ve Yöntem: Çalışmaya Aralık 2019 ile Ekim 2020 arasında akut biliyer pankreatit tanısıyla hastaneye yatırılan hastalar dahil edildi. Olgular hafif pankreatit ve hafif olmayan pankreatit olarak 2 grupta değerlendirildi. Gruplar yaş, beyaz küre sayısı, nötrofil sayısı, C-reaktif protein, hastanede kalış süresi, nötrofil / lenfosit oranı, monosit dağılım genişliği, amilaz, aspartat aminotransferaz, albümin ve laktat dehidrojenaz açısından karşılaştırıldı. Results: Hafif pankreatit grubu (n: 59) ve hafif olmayan pankreatit grubu (n: 48) arasında beyaz küre sayısı, nötrofil sayısı, C-reaktif protein, Monosit Dağılımı Genişliği ve hastanede kalış süresi açısından istatistiksel olarak anlamlı fark belirlendi (p <0.05). Monosit Dağılım Genişliği için cut-off değeri 703.00 olarak alındığında, duyarlılık% 50.94 ve özgüllük% 61.11 idi. Sonuç: Monosit Dağılım Genişliği değeri, hafif pankreatiti hafif olmayan pankreatitten ayırt etmek için kullanılabilen bir parametredir. Daha net bir değerlendirme için daha kapsamlı çalışmalara ihtiyaç vardır.

Anahtar Kelimeler

• akut pankreatit
• monosit dağılım genişliği
• prognoz

Does Monocyte Distribution Width (MDW) Have Prognostic Value in Acute Pancreatitis?

Öz

Aim: Acute pancreatitis is a common disease that can be fatal at advanced stages. Therefore, early evaluation of the prognosis of acute pancreatitis is important. The aim of this study was to evaluate the importance of monocyte distribution width in defining the prognosis of acute pancreatitis. Materials and Methods: The study included patients hospitalized with the diagnosis of acute biliary pancreatitis between December 2019 and October 2020. The cases were evaluated in 2 groups as mild pancreatitis and non-mild pancreatitis. The groups were compared in terms of age, white blood cell, neutrophil count, C-reactive protein, length of hospital stay, neutrophil to lymphocyte ratio, Monocyte Distribution Width, amylase, Aspartate Aminotransferase, albumin, and lactate dehydrogenase. Results: A statistically significant difference was determined between the mild pancreatitis group (n:59) and non-mild pancreatitis group (n:48) in terms of white blood cell, neutrophil count, C-reactive protein, Monocyte Distribution Width and length of hospital stay (p <0.05). When the cut-off value for Monocyte Distribution Width was taken as 703.00, sensitivity was 50.94% and specificity was 61.11.8%. Conclusion: The Monocyte Distribution Width value is a parameter that can be used to differentiate mild pancreatitis from non-mild pancreatitis. More extensive studies are needed for a clearer evaluation.

Anahtar Kelimeler

• acute pancreatitis
• monocyte distrubition width
• prognosis

Kaynakça

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