Effect of perinatal factors on platelet indices in late preterm and term newborns

Öz

Abstract Aim: This study aimed to compare platelet indices between late preterm and term newborns, and to analyze their relationship with perinatal conditions. Materials and Methods: Ninety-eight late preterm and 102 term newborns admitted to the neonatal intensive care unit 2018 and 2020 were retrospectively evaluated. Platelet indices including platelet count (PLT), mean platelet volume (MPV), plateletcrit (PCT), and platelet distribution width (PDW) were measured in blood samples taken on the first day of life. Results: There was no significant difference in the PLT, MPV, PCT, and PDW values between late preterm and term newborns. In late preterm newborns, multivariable analysis showed that maternal hypertension was significantly related to lower PLT (p=0.001). In term newborns, multivariable analysis showed that being small for gestational age (SGA), male sex and maternal hypertension were significantly related to lower PLT (p<0.001, p=0.001 and p=0.017, respectively). In addition, SGA and male sex were related to lower PCT (p=0.001). In all studied patients, MPV was significantly different between infants with and without prolonged rupture of membrane (PROM) (9.8fL vs. 9.2fL, p=0.001). Conclusion: The obtained results show that various perinatal features influence the platelet indices in late preterm and term newborns.

Anahtar Kelimeler

• platelet indices
• late preterm newborns
• platelet count

Geç preterm ve term yenidoğanlarda perinatal faktörlerin trombosit indeksleri üzerindeki etkileri

Öz

Amaç: Bu çalışmanın amacı geç preterm yenidoğanlar ve term yenidoğanlarda trombosit indekslerini karşılaştırmak ve perinatal faktörlerle ilişkisini incelemektir. Gereç ve Yöntemler: 2018-2020 yılları arasında akademik bir merkezin Yenidoğan Yoğun Bakım Ünitesine kabul edilen 98 geç preterm ve 102 term yenidoğan retrospektif olarak değerlendirildi. Yaşamın ilk gününde alınan kan örneklerinde trombosit sayısı (PLT), ortalama trombosit hacmi (MPV), plateletkrit (PCT) ve trombosit dağılım genişliği (PDW) dahil olmak üzere trombosit indeksleri ölçüldü. Bulgular: Geç prematüre ve term yenidoğanlar arasında PLT, MPV, PCT ve PDW değerleri açısından anlamlı fark yoktu. Geç prematüre yenidoğanlarda, çok değişkenli analiz, maternal hipertansiyonun düşük PLT ile anlamlı şekilde ilişkili olduğunu gösterdi (p=0.001). Term yenidoğanlarda, çok değişkenli analiz, gebelik yaşına küçük (SGA) olmak, erkek cinsiyet ve maternal hipertansiyonun düşük PLT ile anlamlı şekilde ilişkili olduğunu gösterdi (sırasıyla p<0.001, p=0.001 ve p=0.017). Ayrıca, SGA ve erkek cinsiyet daha düşük PCT ile ilişkiliydi (p = 0.001). Çalışılan tüm hastalarda, MPV, uzamış membran rüptürü (PROM) olan ve olmayan bebekler arasında önemli ölçüde farklıydı (9.8fL ve 9.2fL, p = 0.001). Tartışma ve Sonuç: Elde edilen sonuçlar, çeşitli perinatal özelliklerin geç preterm ve term yenidoğanların trombosit indekslerini etkilediğini göstermektedir.

Anahtar Kelimeler

• trombosit indeksleri
• geç prematüre yenidoğan
• trombosit sayısı

Kaynakça

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