Association Between ABO Blood Group With Parkinson’s Disease

Yıl 2019, Cilt: 9 Sayı: 3, 227 - 229, 30.09.2019

Oktay Bulur , Osman Korucu

https://doi.org/10.16899/jcm.585387

Öz

Abstract

Background/Aims:Parkinson's disease  is a common 
neurodegenerative disease that seen in adulthood. Most prevelant
symptoms are  resting tremor, rigidity, bradykinesia
,gait disturbance, and postural abnormalities.Disorders related with  ABO 
blood group are infectious disease(cholera,helicobacter
pylori,echerichia coli),cardiovascular disease,malignancies and allergic
status.We objectived to elucidate the association between ABO  blood group and Parkinson's disease

Materials -Methods: We
investigated  retrospectively the files
of 264 adult patients  who were diagnosed with Parkinson's disease and had blood type between
January 2008 and December 2018 in neurology outpatient clinics included
in the study

Results: Distribution
of  blood groups in patients as follows :
ARh(+): 94(%35,6),

ARh(-):15(%5,7),BRh(+):44(%16,7),BRh(-):8(%3),
ABRh(+):18(%6,8),

 ABRh(-):4(%1,5),0Rh(+):71(%26,9),0Rh(-):10(%3,8)

Conclusions: When we consider the pathogenesis of Parkinson’s Disease , we think  of  the antigenic structure of blood groups may be effective in this process.

Anahtar Kelimeler

Dementia, ABO Blood Group, Parkinson

Kaynakça

• Referans 1. Etienne C. Hirsch PJ, Serge Przedborsk. Pathogenesis of Parkinson’s Disease. Movement Disorders. 2012:1-7.
• Referans 2. Caggiu E, Arru G, Hosseini S, Niegowska M, Sechi G, Zarbo IR, et al. Inflammation, Infectious Triggers, and Parkinson's Disease. Frontiers in neurology. 2019;10:122.
• Referans 3. Green C. The ABO, Lewis and related blood group antigens; a review of structure and biosynthesis. FEMS microbiology immunology. 1989;1(6-7):321-30.
• Referans 4. Heggelund JE, Varrot A, Imberty A, Krengel U. Histo-blood group antigens as mediators of infections. Current opinion in structural biology. 2017;44:190-200.
• Referans 5. Liu F, Li C, Zhu J, Ren L, Qi X. ABO blood type and risk of hepatocellular carcinoma: a meta-analysis. Expert review of gastroenterology & hepatology. 2018;12(9):927-33.
• Referans 6. Franchini M, Favaloro EJ, Targher G, Lippi G. ABO blood group, hypercoagulability, and cardiovascular and cancer risk. Critical reviews in clinical laboratory sciences. 2012;49(4):137-49.
• Referans 7. Ewald DR, Sumner SC. Blood type biochemistry and human disease. Wiley interdisciplinary reviews Systems biology and medicine. 2016;8(6):517-35.
• Referans 8. Yıldız ŞM. Distribution of ABO and Rh blood group systems in Cukurova region. Cukurova Med J 2016;41(4):658-63.
• Referans 9. Jaremo P, Milovanovic M, Buller C, Nilsson S, Winblad B. P-selectin paradox and dementia of the Alzheimer type: circulating P-selectin is increased but platelet-bound P-selectin after agonist provocation is compromised. Scandinavian journal of clinical and laboratory investigation. 2013;73(2):170-4.
• Referans 10. Hagnelius NO, Boman K, Nilsson TK. Fibrinolysis and von Willebrand factor in Alzheimer's disease and vascular dementia--a case-referent study. Thrombosis research. 2010;126(1):35-8.
• Referans 11. Quinn TJ GJ, Deary IJ, Lowe GD, Fenton C,, DJ S. Association between circulating hemostaticmeasures and dementia or cognitive impairment: systematic review and meta-analyzes. Thromb Haemost. 2011;9:1475–82.
• Referans 12. Franchini M, Makris M. Non-O blood group: an important genetic risk factor for venous thromboembolism. Blood Transfus. 2013;11(2):164-5.
• Referans 13. De Marco M VA. 'O' blood type is associated with larger grey-matter volumes in the cerebellum. Brain Res Bull. 2015;116:1-6.
• Referans 14. Vasan SK, Rostgaard K, Ullum H, Melbye M, Hjalgrim H, Edgren G. ABO Blood Group and Dementia Risk--A Scandinavian Record-Linkage Study. PLoS One. 2015;10(6):e0129115.
• Referans 15. Renvoize EB. ABO and Rhesus blood groups in Alzheimer's disease. Age Ageing. 1985;14(1):43-5.
• Referans 16. Alexander KS, Zakai NA, Gillett S, McClure LA, Wadley V, Unverzagt F, et al. ABO blood type, factor VIII, and incident cognitive impairment in the REGARDS cohort. Neurology. 2014;83(14):1271-6.
• Referans 17. Chia LG, Liu LH. Parkinson's disease in Taiwan: an analysis of 215 patients. Neuroepidemiology. 1992;11(3):113-20.