Yıl 2020, Cilt 10 , Sayı 2, Sayfalar 163 - 167 2020-06-25

Assessment of the Results of Blood Cultures Taken in the Pediatric Clinic of a Training and Research Hospital in Mogadishu, Somalia
Somali Mogadishu’da Bir Eğitim ve Araştırma Hastanesinin Çocuk Kliniğinde Alınan Kan Kültürlerinin Sonuçlarının Değerlendirilmesi

Cüneyt UĞUR [1]



Aim: The aim of this study is to determine the distribution of microorganisms isolated in blood culture  and their antibiotic susceptibility retrospectively.

Materials and Methods: This study was conducted at the Mogadishu Somalia Türkiye Recep Tayyip Erdogan Training and Research Hospital. A total of 76 patients who were hospitalized to the fpediatric clinic between the years of 2016 and 2018, who had significant reproduction in their culture tests and whose samples was performed antibiogram test were included. Demographic datas, microorganism strains and antibiogram results of these patients were recorded.

Results: The subjects of this study were 37 females (48.7%) and 39 males (51.3%). The mean age of the subjects was 4.68 ± 4.74 (1 month-18 years) years. 57 (75%) of the reproduced microorganisms were Gram-positive bacteria, and 19 (25%) were Gram-negative bacteria. The most commonly isolated bacteria was coagulase-negative staphylococci (CoNS) by 36.8%. It was followed by Staphylococcus aureus (S. aureus) by 19.7%. The most commonly isolated Gram-negative bacteria was Escherichia coli (E. coli) by 6.6%. The antibiotic resistance of CoNS was highest against penicillin G by 85.7%, ampicillin-sulbactam (SAM) by 78.6% and trimethoprim sulfamethoxazole (TMP-SMX) by 75%. The antibiotic resistance of S. aureus was also highest against penicillin G (86.7%), SAM (80%) and TMP-SMX (73.3%).

Conclusion: İt is necessary that conducting studies on this subject as periodic. In this way, it was concluded that morbidity and mortality may be reduced and development of antibiotic resistance may be prevented.



Amaç: Bu çalışmada, kan kültüründe üreyen mikroorganizmaların dağılımının ve antibiyotik duyarlılığının geriye dönük olarak belirlenmesi amaçlandı.

Gereç ve Yöntem: Bu çalışma Mogadishu Somali Türkiye Recep Tayyip Erdoğan Eğitim ve Araştırma Hastanesinde yapıldı. 2016-2018 yılları arasında çocuk servisine yatırılan, kan kültüründe anlamlı üreme olan ve antibiyogram testi yapılan 76 hasta dahil edildi. Bu hastaların demografik verileri, mikroorganizma türleri ve antibiyogram sonuçları  kaydedildi.

Bulgular: Hastaların 37’i kız (% 48.7), 39’ü erkek (% 51.3) idi. Hastaların yaş ortalaması 4.68 ± 4.74 yıl olup, yaş aralığı 1 ay - 18 yıl idi. Üreyen mikroorganizmaların 57’si (%75) gram pozitif bakteri, 19’u (%25) gram negatif bakteri idi. En sık izole edilen etken %36.8 ile koagülaz negatif stafilokok (staphylococci) (KNS) idi. Bunu %19.7 ile Staphylococcus aureus (S.aureus) takip etmekte idi. Gram negatif bakteriler içinde en sık izole edilen ise %6.6 ile Escherchia coli (E. coli) idi. KNS’da antibiyotik direnci en fazla %85.7 ile penisilin G, %78.6 ile ampisilin-sulbactam (SAM) ve %75 ile trimetoprim-sulfametoksazol’a (TMP-SMX) karşı iken, S. aureus’ta da en fazla %86.7 ile penisilin G, %80 ile SAM ve %73.3 ile TMP-SMX’a karşı idi. E.coli’de antibiyotik direnci en fazla %80 ile TMP-SMX, %60 ile ampicillin, amoksicillin-klavulonat, seftriakson ve sefoksitin’e karşı idi.

Sonuç: Belli aralıklarla bu konuda çalışmalar yapılması ve ampirik tedavi seçiminde bu bilgilerin dikkate alınması gerekmektedir. Bu şekilde morbidite ve mortalite azaltılabileceği ve antibiyotik direnç gelişiminin önlenebileceği sonucuna varıldı.

  • 1. Garg A, Anupurba S, Garg J, Goyal RK, Sen MR. Bacteriological profile and antimicrobia resis-tance of blood culture isolates from a university hospital. JIACM. 2007; 8(2): 139-43.
  • 2. Ding JG, Sun QF, Li KC, et al. Retrospective analysis of nosocomial infections in the intensive care unit of a tertiary hospital in China during 2003 and 2007. BMC Infect Dis. 2009; 9: 115.3. Stoesser, N, Moore CE, Pocock JM, et al. Pediatric bloodstream infections in Cambodia, 2007 to 2011. The Pediatr Infect Dis J. 2013;32(7):e272-e76
  • 4. Rosenthal VD. Health-care-associated infections in developing countries. Lancet. 2011; 377: 186–88.
  • 5. Aiken AM, Mturi N, Njuguna P, et al. Risk and causes of paediatric hospital-acquired bacteraemia in Kilifi District Hospital, Kenya: a prospective cohort study. Lancet. 2011;378:2021-27.
  • 6. Berkley JA, Lowe BS, Mwangi I, et al. Bacteremia among children admitted to a rural hospital in Kenya. N Engl J Med. 2005; 352: 39–47. 7. Hill PC, Onyeama CO, Ikumapayi UN, et al. Bacteraemia in patients admitted to an urban hospital in West Africa. BMC Infect Dis. 2007; 7: 2.
  • 8. Bahwere P, Levy J, Hennart P, et al. Community-acquired bacteremia among hospitalized children in rural central Africa. Int J Infect Dis. 2001; 5:180–8. 9. Blomberg B, Jureen R, Manji KP, et al. High rate of fatal cases of pediatric septicemia caused by gram-negative bacteria with extended-spectrum beta-lactamases in Dar es Salaam, Tanzania. J Clin Microbiol. 2005;43:745–9.
  • 10. Khaleel ME, Lone DS, Munir M, Khan JK, Zahra K, Hanif A. A study of microbial isolates from blood at a University Teaching Hospital. Annals King Edward Medical University. 2010;16(3):194-7.
  • 11. Mehta M, Dutta P, Gupta V. Antimicrobial susceptibility pattern of blood isolates from aa teaching hospital in north India. Jpn J Infect Dis. 2005; 58(3):174-6.
  • 12. Mehli M, Gayyurhan ED, Zer Y, Akgün S, Özgür Akın FE, Balcı İ. Microorganism isolated in blood cultures in the Gaziantep University hospital and their susceptibility to antibiotics. Turk J In-fect. 2007;21:141-5.
  • 13. Clinical and Laboratory Standards Institute. Methods for Dilution and AntimicrobialSusceptibility Tests for Bacteria That Grow Aerobically; Approved Standard. 9th ed. Wayne, PA: Clinical and Laboratory Standards Institute; 2012.
  • 14. Winn W, Allen S, Janda W et al. Koneman’s Color Atlas and Textbook of Diagnostic Microbiolo-gy. 6th ed. Philadelphia: JB Lippincott, 2006; 98-9.
  • 15. Kim HJ, Lee NY, Kim S, et al. Characteristics of microorganisms isolated from blood cultures at nine university hospitals in Korea during 2009. Korean J Clin Microbiol. 2011;14(2):48-54.16. Safak, B, Kilinc, O. Microorganisms Isolated From Blood Cultures During 2010-2015 and Their Antimicrobial Susceptibilities. Klimik J. 2016;29(2):60-5.
  • 17. Hoenigl M, Wagner J, Raggam RB, et al. Characteristics of hospital- acquired and community-onset blood stream infections, South-East Austria. PLoS One. 2014;9(8):e104702.18. Kaya S, Arıdoğan BC, Çetin H, Demirci M. Isolated microorganisms in blood culture received children patients and antibiotic resistances. Fırat Med J. 2007;12(1):34-6.
  • 19. Morkel G, Bekker A, Marais BJ, Kirsten G, Van Wyk J, Dramowski A. Bloodstream infections and antimicrobial resistance patterns in a South African neonatal intensive care unit. Paediatr Int Child Health. 2014;34(2):108-14.
  • 20. Karlowsky JA, Jones ME, Draghi DC, Thornsberry C, Sahm DF, Volturo GA. Prevalence and antimicrobial susceptibilities of bacteria isolated from blood cultures of hospitalized patients in the United States in 2002. Annals Clin Microbiol Antimicrob. 2004; 3(1): 7.
  • 21. Reynolds R, Potz N, Colman M, Williams A, Livermore D, MacGowan A. Antimicrobial suscepti-bility of the pathogens of bacteraemia in the UK and Ireland 2001–2002: the BSAC Bacteraemia Re-sistance Surveillance Programme. J Antimicrob Chemother. 2004;53(6):1018-32.
  • 22. Reddy EA, Shaw AV, Crump JA. Community-acquired bloodstream infections in Africa: a sys-tematic review and meta-analysis. Lancet Infect Dis. 2010;10(6):417-32.
  • 23. Blomberg B, Manji K., Urassa WK, et al. Antimicrobial resistance predicts death in Tanzanian children with bloodstream infections: a prospective cohort study. BMC Infect Dis. 2007;7(1):43
Birincil Dil en
Bölüm Orjinal Araştırma
Yazarlar

Orcid: 0000-0002-6260-7719
Yazar: Cüneyt UĞUR (Sorumlu Yazar)
Kurum: Department of Pediatrics, University of Health Sciences, Konya Health Application and Research Center
Ülke: Turkey


Destekleyen Kurum Yok
Tarihler

Kabul Tarihi : 8 Nisan 2020
Yayımlanma Tarihi : 25 Haziran 2020

AMA Uğur C . Assessment of the Results of Blood Cultures Taken in the Pediatric Clinic of a Training and Research Hospital in Mogadishu, Somalia. J Contemp Med. 2020; 10(2): 163-167.