Yıl 2020, Cilt 10 , Sayı 3, Sayfalar 302 - 306 2020-09-30

Relationship between platelet counts, mean platelet volume, platecrit and Beta Thalassemia Carriers
Beta Talasemi Taşıyıcılarında Platekrit, Ortalama Trombosit Volümü ve Trombosit Sayısı Arasındaki İlişki

Hatice Tuba AKBAYRAM [1] , Mustafa ÖRKMEZ [2]


Aim: β-thalassemia carriers (BTC) is generally asymptomatic;
however, in clinical practice, there is hypochromic microcytic mild
anemia caused by a hereditary reduction in beta globin synthesis.
In the literature, there is also some information about platelet
indices in BTC. The aim of this study was to evaluate platelet indices
in children with BTC. In addition, we compared platelet indices
between anemia (Hb<11 g/dl) and non-anemia BTC (Hb ≥11 g/dl).
Material and Method: A cross sectional study included a total
of 153 subjects aged 1-16 years were recruited from Gaziantep
University Hospital outpatient clinics electronic database.
Results: Platelet counts were normal in 90 patients with BTC.
Thrombocytosis and thrombocytopenia were detected in 59
(38.5%) and four (2.6%) patients, respectively. This study group
was divided into two groups as group 1, cases<11 g/dl (n=86), and
group 2, cases≥11g/dl (n=67) according to the hemoglobin levels.
The children with the group 1 had significantly higher mean levels
of platelet counts and platecrit than those with group 2 (p<0.05).
In the logistic regression test, linear correlation between platelet
counts and platecrit (r=0.94, p<0.01) was observed, whereas there
were inverse correlations between platelet counts and age (r=-
0.32, p<0.01), mean platelet volume (r=-0.18, p<0.05), hemoglobin
(r =-0.18, p<0.05).
Conclusion: We found that both thrombocytosis and
thrombocytopenia may occur in BTC. Herein we also found
significantly elevated platelet counts in BTC with anemia.

Giriş: β-talasemi taşıyıcılığı genellikle asemptomatiktir, bununla
beraber beta globin zincirinde kalıtsal azalmadan dolayı hafif
hipokromik mikrositer anemi gelişebilmektedir. Literatürde, talasemi
taşıyıcılarında trombosit parametrelerini değerlendiren az sayıda
çalışma bulunmaktadır. Bu çalışmada amacımız talasemi taşıyıcılarında
trombosit parametrelerini değerlendirmektir. Ayrıca çalışmamızda
anemili ve anemisiz talasemi taşıyıcılarında platelet parametrelerini
değerlendirdik.
Gereç ve Yöntem: Kesitsel çalışmamızda Gaziantep Üniversitesi Tıp
Fakültesi ayaktan hasta polikliniklerine başvuran 1-16 yaş arası 153
talasemi taşıyıcısı çocuk çalışmaya alındı.
Bulgular: Doksan çocuğun trombosit sayıları normaldi. 59 (%38.5)
çocukta trombositoz, dört (%2.6) çocukta trombositopeni saptandı.
Hemoglobin seviyelerine göre iki gruba ayrıldı. Grup 1, hemoglobin<11
g/dl (n=86), ve grup 2, hemoglobin≥11g/dl (n=67)’den oluşmaktaydı.
Grup 1 olgularda trombosit sayısı ve platekrit, grup 2 olgularından
anlamlı olarak yüksekti. (p<0.05) Logistik regresyon testinde trombosit
sayısı ve platekrit arasında lineer bir korelasyon görüldü (r=0.94,
p<0.01), ancak trombosit sayısı ile yaş (r=-0.32, p<0.01), ortalama
trombosit volumü (r=-0.18, p<0.05), hemoglobin (r =-0.18, p<0.05)
arasında negatif bir korelasyon görüldü.
Sonuç: Talasemi taşıyıcılarında hem trombositoz hemde
trombositopeni olabileceğini bulduk. Ayrıca anemi gelişen talasemi
taşıyıcılarında trombosit sayısı anlamlı olarak yüksekti.

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Konular Sağlık Bilimleri ve Hizmetleri
Bölüm Orjinal Araştırma
Yazarlar

Orcid: 0000-0002-9777-9596
Yazar: Hatice Tuba AKBAYRAM (Sorumlu Yazar)
Kurum: Gaziantep Üniversitesi Tıp Fakültesi Aile Hekimliği Anabilim Dalı
Ülke: Turkey


Orcid: 0000-0001-5255-0504
Yazar: Mustafa ÖRKMEZ
Kurum: GAZİANTEP ÜNİVERSİTESİ, TIP FAKÜLTESİ
Ülke: Turkey


Tarihler

Kabul Tarihi : 18 Ağustos 2020
Yayımlanma Tarihi : 30 Eylül 2020

AMA Akbayram H , Örkmez M . Relationship between platelet counts, mean platelet volume, platecrit and Beta Thalassemia Carriers. J Contemp Med. 2020; 10(3): 302-306.