Aim: Nitric oxide (NO) is a molecule known to play a role in many physiological and pathological events in the body. It is thought to play an active role in inflammation. Rheumatoid arthritis (RA) is the most common chronic inflammatory autoimmune disease worldwide. In this study, we aimed to evaluate the serum NO levels of RA patients and their relation with parameters that are indicators of disease activity.
Material and Method: Thirty patients with RA (7 males/ 23 females, mean age 48.80±7.88 years old) and 30 healthy control groups were included in the study. Both groups were compared with erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), rheumatoid factor (RF), anti cyclic citrullinated peptide antibody (anti CCP) and serum NO levels and clinically with Visual Analog Scale (VAS), Disease Activity Score-28 (DAS-28) and Health Assessment Questionnaire (HAQ) scales.
Results: ESR, CRP and NO levels in the patient group were significantly higher than the control group (p<0.05). When the patient group was classified as active and inactive group (active disease: DAS-28> 3.2, inactive disease DAS-28 <3.2) according to DAS-28 scores, there was no significant difference in serum NO levels between the two groups. Serum NO levels of the patient group were not correlated with clinical (VAS, DAS-28) and laboratory markers (ESR, CRP, RF, Anti CCP) of disease activity.
Conclusion: In this study, we found that serum NO levels in RA patients increased significantly compared to the healthy control group. However, increased serum NO levels in RA patients were not associated with laboratory and clinical disease activity parameters.
Nitric oxide, Rheumatoid arthritis, Disease Activity Score-28 (DAS-28), Health Assessment Questionnaire (HAQ)