Yıl 2021, Cilt 11 , Sayı 1, Sayfalar 1 - 6 2021-01-30

Interreader agreement in different PI-RADS systems in multiparametric prostate magnetic resonance imaging: A head-to-head comparison between PI-RADSv2 and v2.1
Multiparametrik prostat manyetik rezonans görüntülemede farklı PI-RADS sistemlerinde okuyucular arası uyum: PI-RADSv2 ve v2.1’in bire bir karşılaştırılması

Mehmet COSKUN [1] , Merve HOROZ [2] , Kazım Ayberk SİNCİ [3] , Kürşad DÖNMEZ [4] , Engin ULUÇ [5]


Aim The purpose of this study is to compare PI-RADSv2 with v2.1 in terms of interreader agreement and diagnostic performance in clinically significant prostate cancer (CSCa) detection. Materials and Methods Two hundred-two patients who had both multiparametric prostate magnetic resonance imaging (mpMRI) and 12 quadrant systematic biopsies were included in this retrospective study. Acquisition parameters were totally complied with proposal of PI-RADSv2 and 2.1 guidelines. mpMRIs were evaluated by two radiologists independently. Index lesion’s score was used to determine diagnostic performance of the systems. Gleason ≥ 3+4 tumors were considered CSCa. Kappa statistic was used to determine interreader agreement. Area under the curve (AUC) was calculated in detection of CSCa using receiver operating characteristic curve (ROC). Results The numbers of cases with PI-RADSv2 and v2.1 scores from 1 to 5 were 46, 21, 13, 41, 81 and 46, 26, 9, 43, 78, by reader 1 and 51, 10, 18, 43, 80 and 51, 15, 19, 37, 80 by reader 2, respectively. There was “substantial” agreement between two readers for both scoring systems. Kappa values were 0.600 in PI-RADSv2 and 0.624 in PI-RADSv2.1. Ninety-eight (48.5%) patients had CSCa. AUC values of PI-RADSv2 and v2.1 scoring systems were 0.861 and 0.851 for reader 1, 0.873 and 0.883 for reader 2, respectively. Conclusion Interreader agreement was “substantial” in mpMRI and slightly improved with PI-RADSv2.1. Diagnostic performance of the two systems were almost equal.
Amaç Bu yazının amacı, okuyucular arası uyum ve klinik anlamlı prostat kanseri (KAK) tespitinde tanısal performans açısından PI-RADSv2 ile v2.1’in karşılaştırılmasıdır. Gereç ve Yöntem Multiparametrik prostat manyetik rezonans görüntüleme (mpMRG) ve 12 kadran sistematik biyopsi yapılan 202 olgu, bu retrospektif çalışmayı oluşturmaktadır. Görüntüleme parametrelerinde PI-RADSv2 ve v2.1’in sunduğu tüm önerilere uyuldu. mpMRG’ler iki radyolog tarafından ayrı ayrı değerlendirildi. Sistemlerin tanısal performansını belirlemede indeks lezyon esas alındı. Gleason ≥ 3+4 tümörler KAK kabul edildi. Okuyucular arası uyumun belirlenmesinde kappa istatistiği kullanıldı. KAK tespitinde eğrinin altındaki alan (EAA), alıcı işletim karakteristiği eğrisi kullanılarak hesaplandı. Bulgular PI-RADSv2 ve v2.1 için skoru 1’den 5’e olan olgu sayısı okuyucu 1 için sırasıyla 46, 21, 13, 41, 81 ve 46, 26, 9, 43, 78 iken, okuyucu 2 için sırasıyla 46, 21, 13, 41, 81 ve 46, 26, 9, 43, 78 idi. Her iki skorlama sistemi için iki okuyucu arasındaki uyum “iyi” düzeydeydi. Kappa değerleri PI-RADSv2 için 0,600, PI-RADSv2.1 için 0,624 idi. Doksan-sekiz (%48,5) olguda KAK görüldü. PI-RADSv2 ve v2.1 skorlama sistemi için EAA değerleri okuyucu 1 için sırasıyla 0,861 ve 0,851, okuyucu 2 için sırasıyla 0,873 ve 0,883 idi. Sonuç Okuyucular arası uyum mpMRG’de “iyi” olup PI-RADSv2.1 ile hafif artmıştır. Her iki sistemin tanısal performansı neredeyse eşittir.
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Konular Sağlık Bilimleri ve Hizmetleri
Bölüm Orjinal Araştırma
Yazarlar

Orcid: 0000-0003-4339-898X
Yazar: Mehmet COSKUN (Sorumlu Yazar)
Kurum: Health Science University Dr. Behçet Uz Child Disease and Surgery Training and Research Hospital, Department of Radiology, İzmir, Turkey
Ülke: Turkey


Orcid: 0000-0002-5564-2196
Yazar: Merve HOROZ
Kurum: İzmir Katip Çelebi University Atatürk Training and Research Hospital, Department of Radiology, İzmir, Turkey
Ülke: Turkey


Orcid: 0000-0002-2207-5850
Yazar: Kazım Ayberk SİNCİ
Kurum: İzmir Katip Çelebi University Atatürk Training and Research Hospital, Department of Radiology, İzmir, Turkey
Ülke: Turkey


Orcid: 0000-0003-3581-3338
Yazar: Kürşad DÖNMEZ
Kurum: İzmir Katip Çelebi University Atatürk Training and Research Hospital, Department of Urology, İzmir, Turkey
Ülke: Turkey


Orcid: 0000-0002-1919-1797
Yazar: Engin ULUÇ
Kurum: İzmir Katip Çelebi University Atatürk Training and Research Hospital, Department of Radiology, İzmir, Turkey
Ülke: Turkey


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Kabul Tarihi : 25 Aralık 2020
Yayımlanma Tarihi : 30 Ocak 2021

AMA Coskun M , Horoz M , Sinci K , Dönmez K , Uluç E . Interreader agreement in different PI-RADS systems in multiparametric prostate magnetic resonance imaging: A head-to-head comparison between PI-RADSv2 and v2.1. J Contemp Med. 2021; 11(1): 1-6.