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Evaluation of Systemic Immune-Inflammation Index as Novel Marker in the Diagnosis of Acute Appendicitis in Children

Yıl 2022, Cilt 12, Sayı 5, 593 - 597, 30.09.2022
https://doi.org/10.16899/jcm.1106843

Öz

Aim: The aim of this study was to determine the usefulness of systemic immune-inflammation index (SII) in the diagnosis of acute appendicitis (AA) in children Material and Method: This study was done retrospectively, and two groups were formed as AA and control group. AA group was divided into two subgroups as nonperforated appendicitis and perforated appendicitis. The groups were compared for age, sex, WBC, neutrophil, lymphocyte and platelet count, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), C-reactive protein (CRP). Results: The study included a total of 162 children. There were 81 children in the AA group and 81 in the control group. Of 81 patients included in the AA group, 31 were girls (38.3%) and 50 were boys (61.7%), and the median age of the patients was 11 (5) years. When the AA group and the control group were compared in terms of laboratory values. It was found that WBC count, neutrophil count, platelet count, NLR, PLR and SII in the AA group were significantly higher and lymphocyte count was significantly lower (p<0.001 for all). When nonperforated and perforated appendicitis groups were compared, there was a significant difference only in CRP value and the CRP value was significantly higher in the perforated appendicitis (groups p<0.001) Conclusion: To the best of our knowledge, present study is the first report to demonstrate the diagnostic value of SII in children with AA. We think that SII can use as novel marker supporting AA diagnosis in children

Kaynakça

  • Uyanik B, Kavalci C, Arslan ED, et.al. Role of mean platelet volume in diagnosis of childhood acute appendicitis. Emerg Med Int 2012.
  • Narci H, Turk E, Karagulle E, Togan T, Karabulut K. The role of mean platelet volume in the diagnosis of acute appendicitis: a retrospective case-controlled study. Iran Red Crescent Med J 2013;15(12):e11934.
  • Duman L, Karaibrahimoğlu A, Büyükyavuz Bİ, Savaş MÇ. Diagnostic Value of Monocyte-to-Lymphocyte Ratio Against Other Biomarkers in Children With Appendicitis. Pediatr Emerg Care 2022;38(2):739-42.
  • Armağan HH, Duman L, Cesur Ö, et al. Comparative analysis of epidemiological and clinical characteristics of appendicitis among children and adults. Ulus Travma Acil Cerrahi Derg 2021;27(5):526-33.
  • Dinc T, Senol K, Yildiz B, Kayilioglu I, Sozen I, Coskun F. Association between red cell distribution width and mean platelet volume with appendicitis: a myth or a fact? Bratisl Lek Listy 2015;116(8):499-501.
  • Uğur C, Madenci H, Kurku H, Neşelioğlu S. The Use of Thiol/Disulfide Homeostasis Parameters in the Diagnosis of Acute Appendicitis in Children. J Pediatr Infect Dis 2020;15:195-9.
  • Trifan G, Testai FD. Systemic Immune-Inflammation (SII) index predicts poor outcome after spontaneous supratentorial intracerebral hemorrhage. J Stroke Cerebrovasc Dis 2020;29(9):105057.
  • Tanacan E, Dincer D, Erdogan FG, Gurler A. A cutoff value for the Systemic Immune-Inflammation Index in determining activity of Behçet disease. Clin Exp Dermatol 2021;46(2):286-91.
  • Kelesoglu S, Yilmaz Y, Elcık D, Kalay N. Systemic immune inflammation index: a novel predictor for coronary collateral circulation. Perfusion 2021.
  • Erdogan T. Role of systemic immune-inflammation index in asthma and NSAID-exacerbated respiratory disease. Clin Respir J 2021;15(4):400-5.
  • Hu B, Yang XR, Xu Y, et al. Systemic immune-inflammation index predicts prognosis of patients after curative resection for hepatocellular carcinoma. Clin Cancer Res 2014;20(23):6212-22.
  • Hong X, Cui B, Wang M, Yang Z, Wang L, Xu Q. Systemic Immune-inflammation Index, Based on Platelet Counts and Neutrophil-Lymphocyte Ratio, Is Useful for Predicting Prognosis in Small Cell Lung Cancer. Tohoku J Exp Med 2015;236(4):297-304.
  • Huang L, Liu S, Lei Y, et al. Systemic immune-inflammation index, thymidine phosphorylase and survival of localized gastric cancer patients after curative resection. Oncotarget 2016;7(28):44185-93.
  • Bal A, Anil M, Nartürk M, et al. Importance of Clinical Decision Making by Experienced Pediatric Surgeons When Children Are Suspected of Having Acute Appendicitis: The Reality in a High-Volume Pediatric Emergency Department. Pediatr Emerg Care 2017;33(9):38-42.
  • Elmas B, Yildiz T, Yazar H, et al. New Oxidative Stress Markers Useful in the Diagnosis of Acute Appendicitis in Children: Thiol/Disulfide Homeostasis and the Asymmetric Dimethylarginine Level. Pediatr Emerg Care 2020;36(8):362-7.
  • Pehlivanlı F, Aydin O. Role of Platelet to Lymphocyte Ratio as a Biomedical Marker for the Pre-Operative Diagnosis of Acute Appendicitis. Surg Infect 2019;20(8):631-6.
  • Yardımcı S, Uğurlu MÜ, Coşkun M, Attaallah W, Yeğen ŞC. Neutrophil-lymphocyte ratio and mean platelet volume can be a predictor for severity of acute appendicitis. Ulus Travma Acil Cerrahi Derg 2016;22(2):163-8.
  • Acharya A, Markar SR, Ni M, Hanna GB. Biomarkers of acute appendicitis: systematic review and cost-benefit trade-off analysis. Surg Endosc 2017;31(3):1022-31.

Çocuklarda Akut Apandisit Tanısında Yeni Bir Belirteç Olarak Sistemik İmmün-İnflamasyon İndeksin Değerlendirilmesi

Yıl 2022, Cilt 12, Sayı 5, 593 - 597, 30.09.2022
https://doi.org/10.16899/jcm.1106843

Öz

Amaç: Bu çalışmanın amacı, çocuklarda akut apandisit (AA) tanısında sistemik immün inflamasyon indeksinin (SII) yararlılığını belirlemektir. Gereç ve Yöntem: Bu çalışma retrospektif olarak yapıldı; AA ve kontrol grubu olmak üzere iki grup oluşturuldu. AA grubu nonperfore apandisit ve perfore apandisit olarak iki alt gruba ayrıldı. Gruplar yaş, cinsiyet, WBC, nötrofil, lenfosit ve trombosit sayısı, nötrofil-lenfosit oranı (NLR), trombosit-lenfosit oranı (PLR), sistemik immün inflamasyon indeksi (SII), C-reaktif protein (CRP) değerleri açısından karşılaştırıldı. Bulgular: Çalışmaya toplam 162 çocuk dahil edildi. AA grubunda 81, kontrol grubunda 81 çocuk vardı. AA grubuna dahil edilen 81 hastanın 31'i kız (%38,3), 50'si erkek (%61,7) olup, hastaların ortanca yaşı 11 (5) yıl idi. AA grubu ve kontrol grubu laboratuvar değerleri açısından karşılaştırıldığında. AA grubunda WBC sayısı, nötrofil sayısı, trombosit sayısı, NLR, PLR ve SII'nin anlamlı derecede yüksek olduğu ve lenfosit sayısının anlamlı derecede düşük olduğu bulundu (tümü için p<0,001). Perfore olmayan ve perfore apandisit grupları karşılaştırıldığında, sadece CRP değerinde anlamlı fark vardı ve perfore apandisit gruplarında CRP değeri anlamlı olarak daha yüksekti (p<0,001) Sonuç: Bilgilerimize göre bu çalışma, AA'lı çocuklarda SII'nin tanısal değerini gösteren ilk rapordur. SII'nin çocuklarda AA tanısını destekleyen yeni bir belirteç olarak kullanılabileceğini düşünüyoruz.

Kaynakça

  • Uyanik B, Kavalci C, Arslan ED, et.al. Role of mean platelet volume in diagnosis of childhood acute appendicitis. Emerg Med Int 2012.
  • Narci H, Turk E, Karagulle E, Togan T, Karabulut K. The role of mean platelet volume in the diagnosis of acute appendicitis: a retrospective case-controlled study. Iran Red Crescent Med J 2013;15(12):e11934.
  • Duman L, Karaibrahimoğlu A, Büyükyavuz Bİ, Savaş MÇ. Diagnostic Value of Monocyte-to-Lymphocyte Ratio Against Other Biomarkers in Children With Appendicitis. Pediatr Emerg Care 2022;38(2):739-42.
  • Armağan HH, Duman L, Cesur Ö, et al. Comparative analysis of epidemiological and clinical characteristics of appendicitis among children and adults. Ulus Travma Acil Cerrahi Derg 2021;27(5):526-33.
  • Dinc T, Senol K, Yildiz B, Kayilioglu I, Sozen I, Coskun F. Association between red cell distribution width and mean platelet volume with appendicitis: a myth or a fact? Bratisl Lek Listy 2015;116(8):499-501.
  • Uğur C, Madenci H, Kurku H, Neşelioğlu S. The Use of Thiol/Disulfide Homeostasis Parameters in the Diagnosis of Acute Appendicitis in Children. J Pediatr Infect Dis 2020;15:195-9.
  • Trifan G, Testai FD. Systemic Immune-Inflammation (SII) index predicts poor outcome after spontaneous supratentorial intracerebral hemorrhage. J Stroke Cerebrovasc Dis 2020;29(9):105057.
  • Tanacan E, Dincer D, Erdogan FG, Gurler A. A cutoff value for the Systemic Immune-Inflammation Index in determining activity of Behçet disease. Clin Exp Dermatol 2021;46(2):286-91.
  • Kelesoglu S, Yilmaz Y, Elcık D, Kalay N. Systemic immune inflammation index: a novel predictor for coronary collateral circulation. Perfusion 2021.
  • Erdogan T. Role of systemic immune-inflammation index in asthma and NSAID-exacerbated respiratory disease. Clin Respir J 2021;15(4):400-5.
  • Hu B, Yang XR, Xu Y, et al. Systemic immune-inflammation index predicts prognosis of patients after curative resection for hepatocellular carcinoma. Clin Cancer Res 2014;20(23):6212-22.
  • Hong X, Cui B, Wang M, Yang Z, Wang L, Xu Q. Systemic Immune-inflammation Index, Based on Platelet Counts and Neutrophil-Lymphocyte Ratio, Is Useful for Predicting Prognosis in Small Cell Lung Cancer. Tohoku J Exp Med 2015;236(4):297-304.
  • Huang L, Liu S, Lei Y, et al. Systemic immune-inflammation index, thymidine phosphorylase and survival of localized gastric cancer patients after curative resection. Oncotarget 2016;7(28):44185-93.
  • Bal A, Anil M, Nartürk M, et al. Importance of Clinical Decision Making by Experienced Pediatric Surgeons When Children Are Suspected of Having Acute Appendicitis: The Reality in a High-Volume Pediatric Emergency Department. Pediatr Emerg Care 2017;33(9):38-42.
  • Elmas B, Yildiz T, Yazar H, et al. New Oxidative Stress Markers Useful in the Diagnosis of Acute Appendicitis in Children: Thiol/Disulfide Homeostasis and the Asymmetric Dimethylarginine Level. Pediatr Emerg Care 2020;36(8):362-7.
  • Pehlivanlı F, Aydin O. Role of Platelet to Lymphocyte Ratio as a Biomedical Marker for the Pre-Operative Diagnosis of Acute Appendicitis. Surg Infect 2019;20(8):631-6.
  • Yardımcı S, Uğurlu MÜ, Coşkun M, Attaallah W, Yeğen ŞC. Neutrophil-lymphocyte ratio and mean platelet volume can be a predictor for severity of acute appendicitis. Ulus Travma Acil Cerrahi Derg 2016;22(2):163-8.
  • Acharya A, Markar SR, Ni M, Hanna GB. Biomarkers of acute appendicitis: systematic review and cost-benefit trade-off analysis. Surg Endosc 2017;31(3):1022-31.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Bilimleri ve Hizmetleri
Bölüm Orjinal Araştırma
Yazarlar

Yeliz KART> (Sorumlu Yazar)
SULEYMAN DEMIREL UNIVERSITY
0000-0003-4282-6540
Türkiye


Cüneyt UĞUR>
Sağlık Bilimleri Üniversitesi Konya Sağlık Uygulama ve Araştırma Merkezi
0000-0002-6260-7719
Türkiye

Erken Görünüm Tarihi 11 Temmuz 2022
Yayımlanma Tarihi 30 Eylül 2022
Kabul Tarihi 23 Mayıs 2022
Yayınlandığı Sayı Yıl 2022, Cilt 12, Sayı 5

Kaynak Göster

AMA Kart Y. , Uğur C. Evaluation of Systemic Immune-Inflammation Index as Novel Marker in the Diagnosis of Acute Appendicitis in Children. J Contemp Med. 2022; 12(5): 593-597.