Klinik Araştırma
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Comparison of Histopathological Characteristics of Laryngeal Squamous Cell Carcinoma in Turkish and Syrian Patient Populations

Yıl 2022, Cilt 12, Sayı 5, 598 - 602, 30.09.2022
https://doi.org/10.16899/jcm.1117908

Öz

Objectives: This study aimed to identify the differences between the tumors and their histopathological characteristics in the materials obtained by laryngectomy performed because of laryngeal squamous cell carcinoma (LSCC) in Turkish and Syrian patient populations. Material and Method: Our study has a retrospective design. The present study included all the patients who were diagnosed with squamous cell carcinoma between January 2010 to January 2021 and underwent laryngectomy in our institute. Medical records, pathology and radiology reports were reviewed. Demographic and histopathological factors were statistically compared between Turkish and Syrian groups. Results: Of 93 cases included in our study, 53 (57%) were Syrian while 40 (43%) were Turkish citizens. We have determined no statistically significant difference between two patient groups. Conclusions: Hatay is a geography that Syrians were familiar with its culture before the war and both societies are exposed to the same environmental conditions. Therefore, we might have found no significant difference between the demographic and histopathological characteristics of laryngeal cancer in Turkish and Syrian patient populations.

Kaynakça

  • UNHCR: Syria Emergency. https://www.unhcr.org/syria-emergency.htm. Accessed 11 May 2021.
  • UNHCR: TurkeyStats. https://www.unhcr.org/tr/n/unhcr-turkey-stats. Accessed 16 June 2021.
  • Kutluk T, Koç M, Öner İ, et al. Cancer among syrian refugees living in Konya Province, Turkey. Confl Health 2022;16.
  • El Saghir NS, Pérez De Celis E, Fares JE, Sullivan R. Cancer care forre fugees and displaced population: middle east conflicts and global natural disasters. Am Soc Clin Oncol Educ B 2018;38:433–40.
  • Abdul-Khalek RA, Guo P, Sharp F, et al.The economic burden of cancer care for Syrian refugees: a population based modelling study. Lancet Oncol 2020;21(5):637–44.
  • Spiegel P, Khalifa A, Mateen FJ. Cancer in refugees in Jordan and Syria between 2009 and 2012: challenges and the way forward in humanitarian emergencies. Lancet Oncology 2014;15: 290–7.
  • Göktaş B, Yılmaz S, Gönenç İM, Akbulut Y, Sözüer A. Cancer incidence among Syrian refugees in Turkey, 2012–2015. J Int Migrat Integrat 2018;19(2):253-8.
  • TemporaryProtection. Republic of Turkey, Ministry of Interior (MoI), Directorate General of Migration Management. https://en.goc.gov.tr/temporary-protection. Accessed 24 Aug 2021.
  • Allegra E,Bianco MR, Ralli M, Greco A, Angeletti D, de Vincentiis M. Role of clinical-demographic data in survival rates of advanced laryngeal cancer. Medicina 2021;57(3):267.
  • Lin Z, Lin H, Chen Y,et al.Long-term survival trend after primary total laryngectomy for patients with locally advanced laryngeal carcinoma. J Cancer 2021;12(4):1220.
  • Gong H, Zhou L, Hsueh CY, et al. Prognostic value of pathological tumor size in patients with supraglottic carcinoma. Am J Otolaryngol 2021;42(1):102757.
  • He Y, Cheng Y, Huang Z, et al. A deep convolutional neural network-based method for laryngeal squamous cell carcinoma diagnosis. Ann Transl Med 2021;9(24).
  • Bradford CR, Ferlito A, Devaney KO, Mäkitie AA, Rinaldo A. Prognostic factors in laryngeal squamous cell carcinoma. Laryngoscope Invest Otolaryngol 2020; 5(1):74-81.
  • Jawad M, Millett C, Sullivan R, Alturki F, Roberts B, Vamos EP. The impact of armed conflict on cancer among civilian populations in low and middle in come countries: a systematic review. E Cancer Med Sci 2020;14:1039.
  • Salman O, Mona M, Robert AF, et al Literature Review and Profile of Cancer Diseases Among Afghan Refugees in Iran: Referrals in Six Years of Displacement. Med Sci Monit 2015;21:3622-8.
  • Marzouk M, Kelley M, Fadhil I, et al. "If I have a cancer, it is not my fault I am a refugee”: a (ualitative study with expert stake holders on cancer care management for Syrian refugees in Jordan. PLoS ONE 2019;14(9):1–19.
  • Akbulut Y, Göktaş B, Kutlu G. An Evaluation of Syrian Refugees’ Utilization of Health services in Turkey. 2nd International Congress on Applied Sciences: Migration, Poverty and Employment-UUBK’2016;250–4.
  • Sung H, Ferlay J, Siegel RL, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin 2021;71:209-49.
  • Alhomsi K,Alamine I, Raiy A, Hadid H, Alkhuja I, Faizeh AQ. Study of squamous cell carcinomas of the larynx and the regional lymph nodes involvement 2019.
  • Castillo-López IY,Govea-Camacho LH, Sánchez-Robles EE, Palacios-López JC. Caracterización clínico-patológica del cáncer de laringe en la población mexicana. Revista Médica del Instituto Mexicano del Seguro Social 2021;59(1):27-33.
  • Kadriyan H, Sulaksana MA, Aryani IGAT, et al. Risk factors and characteristics of laryngeal carcinoma in the developing region of Indonesia. IOP Conference Series: Earth and Environmental Science. Vol. 712. No. 1. IOP Publishing, 2021.
  • Adeel M, Faisal M, Rashid A, et al. An overview of laryngeal cancer treatment at a tertiary care oncological center in a developing country. Cureus 2018;10(6).
  • Gupta A,Gupta P, Jamwal PS. Clinicopathological Study of Cancer Larynx. Int J Sci Study 2019;7(3):34-8.
  • Canova C, Richiardi L, Merletti F, et al. Alcohol, tobacco and genetic susceptibility inrelation to cancers of the upper aerodigestive tract in northern Italy. Tumori 2010;96:1–10.
  • Al-Hakami HA, Garni MAA, AlSubayea H, et al. The incidence of thyroid gland invasion in advanced laryngeal squamous cell carcinoma. Brazil J Otorhinolaryngol 2021;87:533-7.
  • Elliott MS, Odell EW, Tysome JR, et al. Role of thyroidectomy in advanced laryngealand pharyngolaryngeal carcinoma. Otolaryngol Head Neck Surg 2010;142:851-5.

Türk ve Suriyeli Hasta Popülasyonlarında Laringeal Skuamöz Hücreli Karsinomun Histopatolojik Özelliklerinin Karşılaştırılması

Yıl 2022, Cilt 12, Sayı 5, 598 - 602, 30.09.2022
https://doi.org/10.16899/jcm.1117908

Öz

Amaç: Bu çalışmada, Türk ve Suriyeli hasta popülasyonlarında laringeal skuamöz hücreli karsinom (LSCC) nedeniyle yapılan larenjektomi ile elde edilen materyallerdeki tümörler ve histopatolojik özellikleri arasındaki farklılıkların belirlenmesi amaçlanmıştır. Gereç ve Yöntem: Çalışmamız retrospektiftir. Bu çalışmaya Ocak 2010-Ocak 2021 tarihleri arasında skuamöz hücreli karsinom tanısı alan ve kendi merkezimizde larenjektomi uygulanan tüm hastalar dahil edildi. Tıbbi kayıtlar, patoloji ve radyoloji raporları incelendi. Türk ve Suriyeli gruplar arasında demografik ve histopatolojik faktörler istatistiksel olarak karşılaştırıldı. Bulgular: Çalışmamıza dahil edilen 93 olgunun 53'ü (%57) Suriyeli, 40'ı (%43) Türk vatandaşıydı. İki hasta grubu arasında istatistiksel olarak anlamlı bir fark saptamadık. Sonuç: Hatay, Suriyelilerin savaştan önce de kültürüne aşina olduğu ve her iki toplumun da aynı çevre koşullarına maruz kaldığı bir coğrafyadır. Bu nedenle Türk ve Suriyeli hasta popülasyonlarında larinks kanserinin demografik ve histopatolojik özellikleri arasında anlamlı bir fark bulamamış olabiliriz.

Kaynakça

  • UNHCR: Syria Emergency. https://www.unhcr.org/syria-emergency.htm. Accessed 11 May 2021.
  • UNHCR: TurkeyStats. https://www.unhcr.org/tr/n/unhcr-turkey-stats. Accessed 16 June 2021.
  • Kutluk T, Koç M, Öner İ, et al. Cancer among syrian refugees living in Konya Province, Turkey. Confl Health 2022;16.
  • El Saghir NS, Pérez De Celis E, Fares JE, Sullivan R. Cancer care forre fugees and displaced population: middle east conflicts and global natural disasters. Am Soc Clin Oncol Educ B 2018;38:433–40.
  • Abdul-Khalek RA, Guo P, Sharp F, et al.The economic burden of cancer care for Syrian refugees: a population based modelling study. Lancet Oncol 2020;21(5):637–44.
  • Spiegel P, Khalifa A, Mateen FJ. Cancer in refugees in Jordan and Syria between 2009 and 2012: challenges and the way forward in humanitarian emergencies. Lancet Oncology 2014;15: 290–7.
  • Göktaş B, Yılmaz S, Gönenç İM, Akbulut Y, Sözüer A. Cancer incidence among Syrian refugees in Turkey, 2012–2015. J Int Migrat Integrat 2018;19(2):253-8.
  • TemporaryProtection. Republic of Turkey, Ministry of Interior (MoI), Directorate General of Migration Management. https://en.goc.gov.tr/temporary-protection. Accessed 24 Aug 2021.
  • Allegra E,Bianco MR, Ralli M, Greco A, Angeletti D, de Vincentiis M. Role of clinical-demographic data in survival rates of advanced laryngeal cancer. Medicina 2021;57(3):267.
  • Lin Z, Lin H, Chen Y,et al.Long-term survival trend after primary total laryngectomy for patients with locally advanced laryngeal carcinoma. J Cancer 2021;12(4):1220.
  • Gong H, Zhou L, Hsueh CY, et al. Prognostic value of pathological tumor size in patients with supraglottic carcinoma. Am J Otolaryngol 2021;42(1):102757.
  • He Y, Cheng Y, Huang Z, et al. A deep convolutional neural network-based method for laryngeal squamous cell carcinoma diagnosis. Ann Transl Med 2021;9(24).
  • Bradford CR, Ferlito A, Devaney KO, Mäkitie AA, Rinaldo A. Prognostic factors in laryngeal squamous cell carcinoma. Laryngoscope Invest Otolaryngol 2020; 5(1):74-81.
  • Jawad M, Millett C, Sullivan R, Alturki F, Roberts B, Vamos EP. The impact of armed conflict on cancer among civilian populations in low and middle in come countries: a systematic review. E Cancer Med Sci 2020;14:1039.
  • Salman O, Mona M, Robert AF, et al Literature Review and Profile of Cancer Diseases Among Afghan Refugees in Iran: Referrals in Six Years of Displacement. Med Sci Monit 2015;21:3622-8.
  • Marzouk M, Kelley M, Fadhil I, et al. "If I have a cancer, it is not my fault I am a refugee”: a (ualitative study with expert stake holders on cancer care management for Syrian refugees in Jordan. PLoS ONE 2019;14(9):1–19.
  • Akbulut Y, Göktaş B, Kutlu G. An Evaluation of Syrian Refugees’ Utilization of Health services in Turkey. 2nd International Congress on Applied Sciences: Migration, Poverty and Employment-UUBK’2016;250–4.
  • Sung H, Ferlay J, Siegel RL, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin 2021;71:209-49.
  • Alhomsi K,Alamine I, Raiy A, Hadid H, Alkhuja I, Faizeh AQ. Study of squamous cell carcinomas of the larynx and the regional lymph nodes involvement 2019.
  • Castillo-López IY,Govea-Camacho LH, Sánchez-Robles EE, Palacios-López JC. Caracterización clínico-patológica del cáncer de laringe en la población mexicana. Revista Médica del Instituto Mexicano del Seguro Social 2021;59(1):27-33.
  • Kadriyan H, Sulaksana MA, Aryani IGAT, et al. Risk factors and characteristics of laryngeal carcinoma in the developing region of Indonesia. IOP Conference Series: Earth and Environmental Science. Vol. 712. No. 1. IOP Publishing, 2021.
  • Adeel M, Faisal M, Rashid A, et al. An overview of laryngeal cancer treatment at a tertiary care oncological center in a developing country. Cureus 2018;10(6).
  • Gupta A,Gupta P, Jamwal PS. Clinicopathological Study of Cancer Larynx. Int J Sci Study 2019;7(3):34-8.
  • Canova C, Richiardi L, Merletti F, et al. Alcohol, tobacco and genetic susceptibility inrelation to cancers of the upper aerodigestive tract in northern Italy. Tumori 2010;96:1–10.
  • Al-Hakami HA, Garni MAA, AlSubayea H, et al. The incidence of thyroid gland invasion in advanced laryngeal squamous cell carcinoma. Brazil J Otorhinolaryngol 2021;87:533-7.
  • Elliott MS, Odell EW, Tysome JR, et al. Role of thyroidectomy in advanced laryngealand pharyngolaryngeal carcinoma. Otolaryngol Head Neck Surg 2010;142:851-5.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Bilimleri ve Hizmetleri
Bölüm Orjinal Araştırma
Yazarlar

Didar GÜRSOY> (Sorumlu Yazar)
HATAY MUSTAFA KEMAL ÜNİVERSİTESİ, TAYFUR ATA SÖKMEN TIP FAKÜLTESİ, CERRAHİ TIP BİLİMLERİ BÖLÜMÜ, PATOLOJİ ANABİLİM DALI
0000-0002-0674-7047
Türkiye


İlke Evrim SEÇİNTİ>
HATAY MUSTAFA KEMAL ÜNİVERSİTESİ, TAYFUR ATA SÖKMEN TIP FAKÜLTESİ, CERRAHİ TIP BİLİMLERİ BÖLÜMÜ, TIBBİ PATOLOJİ ANABİLİM DALI
0000-0002-8614-3971
Türkiye


Yusuf DORAN>
HATAY MUSTAFA KEMAL ÜNİVERSİTESİ, TAYFUR ATA SÖKMEN TIP FAKÜLTESİ, CERRAHİ TIP BİLİMLERİ BÖLÜMÜ, TIBBİ PATOLOJİ ANABİLİM DALI
0000-0002-9240-5819
Türkiye


Esin DOĞAN>
HATAY MUSTAFA KEMAL ÜNİVERSİTESİ, TAYFUR ATA SÖKMEN TIP FAKÜLTESİ, CERRAHİ TIP BİLİMLERİ BÖLÜMÜ, TIBBİ PATOLOJİ ANABİLİM DALI
0000-0003-3785-6032
Türkiye


Şemsettin OKUYUCU>
HATAY MUSTAFA KEMAL ÜNİVERSİTESİ, TAYFUR ATA SÖKMEN TIP FAKÜLTESİ, CERRAHİ TIP BİLİMLERİ BÖLÜMÜ, KULAK-BURUN, BOĞAZ HASTALIKLARI ANABİLİM DALI
0000-0001-8552-2403
Türkiye

Erken Görünüm Tarihi 11 Temmuz 2022
Yayımlanma Tarihi 30 Eylül 2022
Kabul Tarihi 3 Haziran 2022
Yayınlandığı Sayı Yıl 2022, Cilt 12, Sayı 5

Kaynak Göster

AMA Gürsoy D. , Seçinti İ. E. , Doran Y. , Doğan E. , Okuyucu Ş. Comparison of Histopathological Characteristics of Laryngeal Squamous Cell Carcinoma in Turkish and Syrian Patient Populations. J Contemp Med. 2022; 12(5): 598-602.