Klinik Araştırma
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Investigation of Helicobacter pylori Antigen Positivity and Intestinal Parasite Coexistence in Stool Samples

Yıl 2022, Cilt 12, Sayı 5, 757 - 760, 30.09.2022
https://doi.org/10.16899/jcm.1136306

Öz

Aim: Helicobacter pylori and intestinal parasitic infections are commonly seen, especially in areas with low socioeconomic status and poor hygiene conditions. H. pylori and Giardia duodenalis can be commonly found in patients with upper gastrointestinal system complaints. It is thought that the urease activity of H. pylori may help intestinal parasites pass into the intestines without being affected by the acidic environment of the stomach. In this study, it was aimed to investigate the association of H. pylori and intestinal parasites (IP) in patients with gastrointestinal system complaints. Material and Method: A total of 408 patients, who were admitted to our hospital with gastrointestinal complaints between 2018 and 2020 and whose H. pylori rapid antigen test was studied simultaneously with intestinal parasite examination in the stool, were evaluated retrospectively. Results: Out of 408 patients whose stool samples were examined, one or more intestinal parasites were detected in 80 (19.6%), and H. pylori antigen test was positive in 65 (15.9%). While there was no statistically significant difference between H. pylori positivity and age groups, the rate of IP detection was found to be significantly higher in children aged 6-18 years. The most prevalent IP was Blastocystis sp. in 74 (18.1%) patients. Intestinal parasite and H. pylori antigen co-positivity in stool samples was detected in eight patients and it was not found statistically significant. Conclusion: H. pylori and intestinal parasites are common all over the world. The relationship between H. pylori and IP is still controversial, and more studies that are comprehensive are needed to understand the association of H. pylori and IP, especially in patients with upper gastrointestinal system complaints.

Kaynakça

  • Wong LW, Ong KS, Khoo JR, Goh CBS, Hor JW, Lee SM. Human intestinal parasitic infection:a narrative review on global prevalence and epidemiological insights on preventive, therapeutic and diagnostic strategies for future perspectives. Expert Rev Gastroenterol Hepatol 2020;14(11):1093-105.
  • Olopade BO, Idowu CO, Oyelese AO, Aboderin AO. Intestinal parasites, nutritional status and cognitive function among primary school pupils in Ile-Ife, Osun State, Nigeria. Afr J Infect Dis 2018;12(2):21-8.
  • Ostan I, Kilimcioğlu AA, Girginkardeşler N, Ozyurt BC, Limoncu ME, Ok UZ. Health inequities:lower socio-economic conditions and higher incidences of intestinal parasites. BMC Public Health 2007;7:342.
  • Lehours P. Actual diagnosis of Helicobacter pylori infection. Minerva Gastroenterol Dietol 2018;64(3):267-79.
  • Öztekin M, Yılmaz B, Ağagündüz D, Capasso R. Overview of Helicobacter pylori Infection:Clinical Features, Treatment, and Nutritional Aspects. Diseases 2021;9(4):66.
  • Seid A, Tamir Z, Kasanew B, Senbetay M. Co-infection of intestinal parasites and Helicobacter pylori among upper gastrointestinal symptomatic adult patients attending Mekanesalem Hospital, northeast Ethiopia. BMC Res Notes 2018;11(1):144.
  • Taghipour A, Bahadory S, Badri M, et al. A systematic review and meta-analysis on the co-infection of Helicobacter pylori with intestinal parasites:public health issue or neglected correlation?. Int J Environ Health Res 2022;32(4):808-18.
  • Maçin S, Demir H, Özen H, Yüce A, Akyön Y. Determination of Helicobacter pylori antibiotic resistance patterns in pediatric gastroenterologypatients:the Hacettepe experience. Turk J Pediatr 2015;57:254-57.
  • Maçin S, Kaya F, Çağdaş D, et al. Detection of parasites in children with chronic diarrhea. Pediatr Int. 2016;58(6):531-3.
  • Yakoob J, Abbas Z, Khan R, Tariq K, Awan S, Beg MA. Association of Helicobacter pylori and protozoal parasites in patients with chronic diarrhoea. Br J Biomed Sci 2018;75(3):105-09.
  • Yousif Abd Elbagi Y, Abd Alla AB, Saad MBE. The relationship between Helicobacter pylori infection and intestinal parasites in individuals from Khartoum state, Sudan:a case-control study. F1000Res 2019;8:2094.
  • Spotts H, Walelign S, Tesfaye M, Desta K, Tsegaye A, Taye B. Concurrent infection of intestinal parasites and Helicobacter pylori among school-age children in Central Ethiopia. Parasite Epidemiol Control 2020;11:e00177.
  • Krzyżek P, Gościniak G. Frequency and immunological consequences of Helicobacter pylori and intestinal parasite co-infections:a brief review. Ann Parasitol 2017;63(4):255-63.
  • Ghallab M, Morsy S. Helicobacter pylori co-infected with common intestinal protozoa in gastrointestinal symptomatic patients. J Egypt Soc Parasitol 2020;50(2):390-3.
  • Ibrahim A, Ali YBM, Abdel-Aziz A, El-Badry AA. Helicobacter pylori and enteric parasites co-infection among diarrheic and non-diarrheic Egyptian children:seasonality, estimated risks, and predictive factors. J Parasit Dis 2019;43(2):198-08.
  • Pomari E, Ursini T, Silva R, Leonardi M, Ligozzi M, Angheben A. Concomitant Infection of Helicobacter pylori and Intestinal Parasites in Adults Attending a Referral Centre for Parasitic Infections in North Eastern Italy. J Clin Med 2020;9(8):2366.
  • Majeed GH, Mohammed NS, Muhsen SS. The synergistic effect of Blastocystis hominis and H. pylori in Iraqi colorectal cancer patients. J Pharm Sci Res Vol 2019;11(2):523-26.
  • Uğraş M, Miman O. The prevalence of intestinal parasites in children with Helicobacter pylori gastritis evaluated retrospectively. Turkiye Parazitol Derg 2013;37(4):245-48.

Gaita Örneklerinde Helicobacter pylori Antijen Pozitifliği ile İntestinal Parazit Birlikteliğinin Araştırılması

Yıl 2022, Cilt 12, Sayı 5, 757 - 760, 30.09.2022
https://doi.org/10.16899/jcm.1136306

Öz

Amaç: Helicobacter pylori enfeksiyonu ve intestinal paraziter enfeksiyonlar, özellikle düşük sosyoekonomik düzey ve kötü hijyen koşullarına sahip bölgelerde yaygın olarak görülmeye devam etmektedir. Özellikle üst gastrointestinal sistem şikayeti olan hastalarda H. pylori ve Giardia intestinalis gibi patojenler etken olarak saptanabilmektedir. H. pylori’nin üreaz aktivitesinin intestinal parazitlerin midenin asidik ortamından etkilenmeden bağırsaklara geçişine yardımcı olabileceği düşünülmektedir. Bu çalışmada gastrointestinal sistem şikayeti olan hastalarda H. pylori ve intestinal parazit (IP) birlikteliğinin araştırılması amaçlanmıştır. Gereç ve Yöntem: Hastanemize 2018-2020 yılları arasında gastrointestinal şikayetlerle başvurmuş ve gaitada intestinal parazit incelemesi ile eş zamanlı olarak H. pylori hızlı antijen testi çalışılmış toplam 408 hasta retrospektif olarak değerlendirilmiştir. Bulgular: Gaita örnekleri incelenen toplam 408 hastanın 80’inde (%19,6) bir ya da daha fazla sayıda intestinal parazit, 65’inde ise (%15,9) gaitada H. pylori antijen testi pozitif olarak tespit edilmiştir. IP saptanma oranı 6-18 yaş arasındaki çocuklarda anlamlı derecede yüksek bulunmuştur. En fazla tespit edilen IP Blastocystis sp. olup 74 (%18,1) hastada saptanmıştır. Gaitada H. pylori antijen pozitifliği ile birlikte intestinal parazit pozitifliği toplam sekiz hastada tespit edilmiş ve istatistiksel olarak anlamlı bulunmamıştır. Sonuç: H. pylori ve intestinal parazitler tüm dünyada yaygın olarak görülmektedir. H. pylori ve IP arasındaki ilişkili halen tartışmalı olup özellikle üst gastrointestinal sistem şikayeti olan hastalarda H. pylori ile IP birlikteliğinin anlaşılabilmesi için daha geniş kapsamlı çalışmalara ihtiyaç vardır.

Kaynakça

  • Wong LW, Ong KS, Khoo JR, Goh CBS, Hor JW, Lee SM. Human intestinal parasitic infection:a narrative review on global prevalence and epidemiological insights on preventive, therapeutic and diagnostic strategies for future perspectives. Expert Rev Gastroenterol Hepatol 2020;14(11):1093-105.
  • Olopade BO, Idowu CO, Oyelese AO, Aboderin AO. Intestinal parasites, nutritional status and cognitive function among primary school pupils in Ile-Ife, Osun State, Nigeria. Afr J Infect Dis 2018;12(2):21-8.
  • Ostan I, Kilimcioğlu AA, Girginkardeşler N, Ozyurt BC, Limoncu ME, Ok UZ. Health inequities:lower socio-economic conditions and higher incidences of intestinal parasites. BMC Public Health 2007;7:342.
  • Lehours P. Actual diagnosis of Helicobacter pylori infection. Minerva Gastroenterol Dietol 2018;64(3):267-79.
  • Öztekin M, Yılmaz B, Ağagündüz D, Capasso R. Overview of Helicobacter pylori Infection:Clinical Features, Treatment, and Nutritional Aspects. Diseases 2021;9(4):66.
  • Seid A, Tamir Z, Kasanew B, Senbetay M. Co-infection of intestinal parasites and Helicobacter pylori among upper gastrointestinal symptomatic adult patients attending Mekanesalem Hospital, northeast Ethiopia. BMC Res Notes 2018;11(1):144.
  • Taghipour A, Bahadory S, Badri M, et al. A systematic review and meta-analysis on the co-infection of Helicobacter pylori with intestinal parasites:public health issue or neglected correlation?. Int J Environ Health Res 2022;32(4):808-18.
  • Maçin S, Demir H, Özen H, Yüce A, Akyön Y. Determination of Helicobacter pylori antibiotic resistance patterns in pediatric gastroenterologypatients:the Hacettepe experience. Turk J Pediatr 2015;57:254-57.
  • Maçin S, Kaya F, Çağdaş D, et al. Detection of parasites in children with chronic diarrhea. Pediatr Int. 2016;58(6):531-3.
  • Yakoob J, Abbas Z, Khan R, Tariq K, Awan S, Beg MA. Association of Helicobacter pylori and protozoal parasites in patients with chronic diarrhoea. Br J Biomed Sci 2018;75(3):105-09.
  • Yousif Abd Elbagi Y, Abd Alla AB, Saad MBE. The relationship between Helicobacter pylori infection and intestinal parasites in individuals from Khartoum state, Sudan:a case-control study. F1000Res 2019;8:2094.
  • Spotts H, Walelign S, Tesfaye M, Desta K, Tsegaye A, Taye B. Concurrent infection of intestinal parasites and Helicobacter pylori among school-age children in Central Ethiopia. Parasite Epidemiol Control 2020;11:e00177.
  • Krzyżek P, Gościniak G. Frequency and immunological consequences of Helicobacter pylori and intestinal parasite co-infections:a brief review. Ann Parasitol 2017;63(4):255-63.
  • Ghallab M, Morsy S. Helicobacter pylori co-infected with common intestinal protozoa in gastrointestinal symptomatic patients. J Egypt Soc Parasitol 2020;50(2):390-3.
  • Ibrahim A, Ali YBM, Abdel-Aziz A, El-Badry AA. Helicobacter pylori and enteric parasites co-infection among diarrheic and non-diarrheic Egyptian children:seasonality, estimated risks, and predictive factors. J Parasit Dis 2019;43(2):198-08.
  • Pomari E, Ursini T, Silva R, Leonardi M, Ligozzi M, Angheben A. Concomitant Infection of Helicobacter pylori and Intestinal Parasites in Adults Attending a Referral Centre for Parasitic Infections in North Eastern Italy. J Clin Med 2020;9(8):2366.
  • Majeed GH, Mohammed NS, Muhsen SS. The synergistic effect of Blastocystis hominis and H. pylori in Iraqi colorectal cancer patients. J Pharm Sci Res Vol 2019;11(2):523-26.
  • Uğraş M, Miman O. The prevalence of intestinal parasites in children with Helicobacter pylori gastritis evaluated retrospectively. Turkiye Parazitol Derg 2013;37(4):245-48.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Bilimleri ve Hizmetleri
Bölüm Orjinal Araştırma
Yazarlar

Filiz DEMİREL> (Sorumlu Yazar)
Sağlık Bilimleri Üniversitesi, Ankara Eğitim ve Araştırma Hastanesi
0000-0002-3513-8347
Türkiye


Kübra EVREN>
Sağlık Bilimleri Üniversitesi, Ankara Eğitim ve Araştırma Hastanesi
0000-0002-2512-470X
Türkiye

Erken Görünüm Tarihi 11 Temmuz 2022
Yayımlanma Tarihi 30 Eylül 2022
Kabul Tarihi 23 Temmuz 2022
Yayınlandığı Sayı Yıl 2022, Cilt 12, Sayı 5

Kaynak Göster

AMA Demirel F. , Evren K. Investigation of Helicobacter pylori Antigen Positivity and Intestinal Parasite Coexistence in Stool Samples. J Contemp Med. 2022; 12(5): 757-760.