Pulmoner Tutulumu Olan Sistemik Skleroz Hastalarında Hematolojik Parametrelerin Rolü

Yıl 2022, Cilt: 12 Sayı: 5, 608 - 616, 30.09.2022

Dilek Tezcan Çağrı Turan Selda Hakbilen Sema Yilmaz

https://doi.org/10.16899/jcm.1141481

Öz

Amaç: Sistemik skleroz (SSc), mikro ve makroanjiyopati ile karakterize otoimmun bir hastalıktır. SSc'deki mortalite esas olarak pulmoner komplikasyonlara bağlıdır. Bu çalışma, SSc hastalarının vasküler ve parankimal pulmoner tutulumları ile hematolojik parametreler arasındaki ilişkiyi ortaya koymayı amaçladı.
Gereç ve Yöntem: Katılımcılar, SSc tanılı interstisyel akciğer hastalığı (İAH) ile birlikte pulmoner hipertansiyonu (PH) olanlar, sadece İAH'si olanlar ve İAH ve PH'si olmayan hastalar olmak üzere üç gruba ayrıldı. Laboratuvar verileri bu gruplar arasında karşılaştırıldı
Bulgular: İAH'nIn PH'dan bağımsız olarak yüksek kırmızı hücre dağılım genişliği (RDW) ve eritrosit sedimantasyon hızı ile ilişkili olduğu bulundu. Trombosit (PLT) sayısı anlamlı olarak daha düşüktü ve RDW / PLT oranı (RPO) seviyesi İAH ve PH birlikteliği olanlarda sadece İAH olanlara göre anlamlı olarak daha yüksekti.
Sonuç: RPR, SSc ile ilişkili İAH'da PH için tarama parametreleri olarak kullanılabilir.

Anahtar Kelimeler

interstisyel akciğer hastalığı, pulmoner hipertansiyon, sistemik skleroz

Destekleyen Kurum

yok

Proje Numarası

yok

Role of Hematological Parameters in Systemic Sclerosis Patients with Pulmonary System Involvement

Öz

Aim: Systemic sclerosis (SSc) is an autoimmune disease characterized by generalized micro and macroangiopathy. Mortality in SSc is primarily due to pulmonary complications. This study was aimed to reveal the relationship between parenchymal and vascular involvements of the pulmonary system and hematological parameters in patients with SSc.
Material and Method: Participants were divided into three groups: both interstitial lung disease (ILD) and pulmonary hypertension (PH), those with only ILD and those with neither ILD nor PH. Laboratory data were compared between these groups.
Results: ILD was found to be associated with high red cell distribution width (RDW) and erythrocyte sedimentation rate, independent of PH. The platelet (PLT) count was significantly lower, and the RDW to PLT ratio (RPR) level was significantly higher in those with ILD and PH coexistence compared to those with only ILD.
Conclusion: RPR can be used as screening parameters for PH in ILD associated with SSc.

Anahtar Kelimeler

Interstitial lung disease, pulmonary hypertension, systemic sclerosis

Proje Numarası

yok

Kaynakça

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