Klinik Araştırma
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Association of systemic immune-inflammation index with long-term all-cause mortality in pancreatic cancer patients after pancreaticoduodenectomy

Yıl 2022, Cilt 12, Sayı 6, 851 - 855, 30.11.2022
https://doi.org/10.16899/jcm.1155707

Öz

Aim: Systemic immune-inflammation (SII) index may provide more promising prognostic information in patients with cancer surgery. However, to the best of our knowledge, the prognostic value of SII index in patients with pancreatic cancer who underwent pancreaticoduodenectomy has not been studied. Thus, this study aimed to evaluate and compare the prognostic value of SII index in patients with pancreatic cancer who underwent pancreaticoduodenectomy. Materials and Methods: All patients over 18 years-old that underwent successful pancreaticoduodenectomy due to pancreatic cancer between February 20, 2019 and June 30, 2021 at Ankara City Hospital Department of General Surgery were included. The main predictor of interest was SII index which was measured by neutrophil*platelet / lymphocyte count. The main outcome of the study was long-term all-cause mortality. Results: A total of 223 patients were included in the current study. Multivariable cox regression analysis revealed that history of congestive heart failure [HR (95%CI): 3.682 (1.140-11.892)], and SII index [HR (95%CI): 1.001 (1.001-1.001)] were independently associated with all cause long-term mortality. The accuracy of predicting mortality for SII index was assessed by the area under the ROC curve which was = 0.77. A higher value of 1305 of SII index was found with 76% sensitivity and 67% specificity for predicting all-cause long-term mortality. Conclusions: The results of the study suggest that measurement of the SII index, an easily available and relatively cheap marker, is an independent predictor of long-term survival after pancreaticoduodenectomy in patients with pancreatic cancer.

Kaynakça

  • Clancy TE. Surgery for pancreatic cancer. Hematology/Oncology Clinics 2015; 29 (4):701-716.
  • Grainne M, Knox JJ. Locally advanced pancreatic cancer: An emerging entity. Current problems in cancer 2018; 42 (1):12-25.
  • Morris-Stiff G, Alabraba E, Tan Y-M, Shapey I, Bhati C, Tanniere P, et al. Assessment of survival advantage in ampullary carcinoma in relation to tumour biology and morphology. European Journal of Surgical Oncology (EJSO) 2009; 35 (7):746-750.
  • Colussi O, Voron T, Pozet A, Hammel P, Sauvanet A, Bachet J, et al. Prognostic score for recurrence after Whipple's pancreaticoduodenectomy for ampullary carcinomas; results of an AGEO retrospective multicenter cohort. European Journal of Surgical Oncology (EJSO) 2015; 41 (4):520-526.
  • Miyakawa S, Ishihara S, Horiguchi A, Takada T, Miyazaki M, Nagakawa T. Biliary tract cancer treatment: 5,584 results from the Biliary Tract Cancer Statistics Registry from 1998 to 2004 in Japan. Journal of hepato-biliary-pancreatic surgery 2009; 16 (1):1-7.
  • Hsu H-P, Yang T-M, Hsieh Y-H, Shan Y-S, Lin P-W. Predictors for patterns of failure after pancreaticoduodenectomy in ampullary cancer. Annals of surgical oncology 2007; 14 (1):50-60.
  • Palta M, Patel P, Broadwater G, Willett C, Pepek J, Tyler D, et al. Carcinoma of the ampulla of Vater: patterns of failure following resection and benefit of chemoradiotherapy. Annals of surgical oncology 2012; 19 (5):1535-1540.
  • Rumba R, Cipkina S, Cukure F, Vanags A. Systemic and local inflammation in colorectal cancer. Acta Med Litu 2018; 25 (4):185-196.
  • Tuomisto AE, Makinen MJ, Vayrynen JP. Systemic inflammation in colorectal cancer: Underlying factors, effects, and prognostic significance. World J Gastroenterol 2019; 25 (31):4383-4404.
  • Zhang K, Hua YQ, Wang D, Chen LY, Wu CJ, Chen Z, et al. Systemic immune-inflammation index predicts prognosis of patients with advanced pancreatic cancer. J Transl Med 2019; 17 (1):30.
  • Padoan A, Plebani M, Basso D. Inflammation and Pancreatic Cancer: Focus on Metabolism, Cytokines, and Immunity. Int J Mol Sci 2019; 20 (3).
  • Shilpa MD, Kalyani R, Sreeramulu P. Prognostic value of pre-treatment routine hematological parameters in breast carcinoma: Advantageous or deleterious? Biomedical Research and Therapy 2020; 7 (8):3916-3920.
  • Gennigens C, De Cuypere M, Seidel L, Hermesse J, Barbeaux A, Forget F, et al. Correlation between hematological parameters and outcome in patients with locally advanced cervical cancer treated by concomitant chemoradiotherapy. Cancer Medicine 2020; 9 (22):8432-8443.
  • Cao Y, Gu J, Yan L, Deng S, Mao F, Cai W, et al. The value of haematological parameters and serum tumour markers for predicting KRAS mutations in 784 Chinese colorectal cancer patients: a retrospective analysis. BMC cancer 2020; 20 (1):1-9.
  • Rawla P, Sunkara T, Gaduputi V. Epidemiology of pancreatic cancer: global trends, etiology and risk factors. World journal of oncology 2019; 10 (1):10.

Pankreas kanseri hastalarında pankreatikoduodenektomi sonrası sistemik immün-inflamasyon indeksi ile uzun dönem mortalite arasındaki ilişki

Yıl 2022, Cilt 12, Sayı 6, 851 - 855, 30.11.2022
https://doi.org/10.16899/jcm.1155707

Öz

Amaç: Sistemik immün inflamasyon (Sİİ) indeksi, kanser cerrahisi geçiren hastalarda umut verici prognostik bilgiler sağlayabilir. Pankreatikoduodenektomi yapılan pankreas kanseri tanılı hastalarda Sİİ indeksinin prognostik değeri daha önce araştırılmamıştır. Bu nedenle, bu çalışmada pankreatikoduodenektomi yapılan pankreas kanserli hastalarda Sİİ indeksinin prognostik değerini değerlendirmeyi amaçladık. Gereç ve Yöntem: 20 Şubat 2019 - 30 Haziran 2021 tarihleri ​​arasında Ankara Şehir Hastanesi Genel Cerrahi Kliniği'nde pankreas kanseri nedeniyle pankreatikoduodenektomi yapılan 18 yaş üstü tüm hastalar çalışmaya dahil edildi. İlgilenilen ana belirteç, nötrofil*trombosit/lenfosit sayısı ile ölçülen Sİİ indeksiydi. Çalışmanın ana sonlanım noktası, tüm nedenlere bağlı uzun dönem mortaliteydi. Bulgular: Çalışmaya toplam 223 hasta dahil edildi. Çok değişkenli Cox regresyon analizi, konjestif kalp yetmezliği öyküsü [HR (%95 GA): 3.682 (1.140-11.892)] ve Sİİ indeksinin [HR (%95 GA): 1.001 (1.001-1.001)] uzun dönem mortalite ile bağımsız olarak ilişkili olduğunu gösterdi. Sİİ indeksinin mortalite öngörü doğruluğunu değerlendirmek için yapılan ROC analizinde eğri altında kalan alan 0.77 olarak belirlendi. Sİİ indeksinin 1305 ve üzerinde olmasının uzun dönem mortaliteyi öngörü duyarlılığı %76, özgüllüğü %67 olarak hesaplandı. Sonuçlar: Çalışmanın sonuçları, kolay elde edilebilen ve nispeten ucuz bir belirteç olan Sİİ indeksinin, pankreas kanseri tanılı hastalarda pankreatikoduodenektomi sonrası uzun dönem sağkalımı bağımsız olarak öngördürebilecek bir parametre olduğunu göstermektedir.

Kaynakça

  • Clancy TE. Surgery for pancreatic cancer. Hematology/Oncology Clinics 2015; 29 (4):701-716.
  • Grainne M, Knox JJ. Locally advanced pancreatic cancer: An emerging entity. Current problems in cancer 2018; 42 (1):12-25.
  • Morris-Stiff G, Alabraba E, Tan Y-M, Shapey I, Bhati C, Tanniere P, et al. Assessment of survival advantage in ampullary carcinoma in relation to tumour biology and morphology. European Journal of Surgical Oncology (EJSO) 2009; 35 (7):746-750.
  • Colussi O, Voron T, Pozet A, Hammel P, Sauvanet A, Bachet J, et al. Prognostic score for recurrence after Whipple's pancreaticoduodenectomy for ampullary carcinomas; results of an AGEO retrospective multicenter cohort. European Journal of Surgical Oncology (EJSO) 2015; 41 (4):520-526.
  • Miyakawa S, Ishihara S, Horiguchi A, Takada T, Miyazaki M, Nagakawa T. Biliary tract cancer treatment: 5,584 results from the Biliary Tract Cancer Statistics Registry from 1998 to 2004 in Japan. Journal of hepato-biliary-pancreatic surgery 2009; 16 (1):1-7.
  • Hsu H-P, Yang T-M, Hsieh Y-H, Shan Y-S, Lin P-W. Predictors for patterns of failure after pancreaticoduodenectomy in ampullary cancer. Annals of surgical oncology 2007; 14 (1):50-60.
  • Palta M, Patel P, Broadwater G, Willett C, Pepek J, Tyler D, et al. Carcinoma of the ampulla of Vater: patterns of failure following resection and benefit of chemoradiotherapy. Annals of surgical oncology 2012; 19 (5):1535-1540.
  • Rumba R, Cipkina S, Cukure F, Vanags A. Systemic and local inflammation in colorectal cancer. Acta Med Litu 2018; 25 (4):185-196.
  • Tuomisto AE, Makinen MJ, Vayrynen JP. Systemic inflammation in colorectal cancer: Underlying factors, effects, and prognostic significance. World J Gastroenterol 2019; 25 (31):4383-4404.
  • Zhang K, Hua YQ, Wang D, Chen LY, Wu CJ, Chen Z, et al. Systemic immune-inflammation index predicts prognosis of patients with advanced pancreatic cancer. J Transl Med 2019; 17 (1):30.
  • Padoan A, Plebani M, Basso D. Inflammation and Pancreatic Cancer: Focus on Metabolism, Cytokines, and Immunity. Int J Mol Sci 2019; 20 (3).
  • Shilpa MD, Kalyani R, Sreeramulu P. Prognostic value of pre-treatment routine hematological parameters in breast carcinoma: Advantageous or deleterious? Biomedical Research and Therapy 2020; 7 (8):3916-3920.
  • Gennigens C, De Cuypere M, Seidel L, Hermesse J, Barbeaux A, Forget F, et al. Correlation between hematological parameters and outcome in patients with locally advanced cervical cancer treated by concomitant chemoradiotherapy. Cancer Medicine 2020; 9 (22):8432-8443.
  • Cao Y, Gu J, Yan L, Deng S, Mao F, Cai W, et al. The value of haematological parameters and serum tumour markers for predicting KRAS mutations in 784 Chinese colorectal cancer patients: a retrospective analysis. BMC cancer 2020; 20 (1):1-9.
  • Rawla P, Sunkara T, Gaduputi V. Epidemiology of pancreatic cancer: global trends, etiology and risk factors. World journal of oncology 2019; 10 (1):10.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Bilimleri ve Hizmetleri
Bölüm Orjinal Araştırma
Yazarlar

Aziz Ahmet SUREL> (Sorumlu Yazar)
SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, ANKARA ŞEHİR SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ, CERRAHİ TIP BİLİMLERİ BÖLÜMÜ, GENEL CERRAHİ ANABİLİM DALI
0000-0002-4819-8242
Türkiye


Serap ULUSOY>
SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, ANKARA ŞEHİR SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ, CERRAHİ TIP BİLİMLERİ BÖLÜMÜ, GENEL CERRAHİ ANABİLİM DALI
0000-0001-9014-7070
Türkiye


Muhammet Kadri ÇOLAKOĞLU>
SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, ANKARA ŞEHİR SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ, CERRAHİ TIP BİLİMLERİ BÖLÜMÜ, GENEL CERRAHİ ANABİLİM DALI
0000-0002-6283-943X
Türkiye

Erken Görünüm Tarihi 1 Ekim 2022
Yayımlanma Tarihi 30 Kasım 2022
Kabul Tarihi 4 Kasım 2022
Yayınlandığı Sayı Yıl 2022, Cilt 12, Sayı 6

Kaynak Göster

AMA Surel A. A. , Ulusoy S. , Çolakoğlu M. K. Association of systemic immune-inflammation index with long-term all-cause mortality in pancreatic cancer patients after pancreaticoduodenectomy. J Contemp Med. 2022; 12(6): 851-855.