Oxidative Stress Index and Vitamin C in The Diagnosis of Fibromyalgia Syndrome

Yıl 2022, Cilt: 12 Sayı: 6, 1007 - 1012, 30.11.2022

Muzaffer Katar Köksal Deveci Hülya Deveci

https://doi.org/10.16899/jcm.1173658

Cited By: 1

Öz

Aim: Still there is no any specific laboratory marker for diagnosis of FMS and it mainly depends on clinical examination. So that we aimed to evaluate whether serum Vitamin C levels and oxidative stress index (OSI) can be used in the diagnosis of Fibromyalgia Syndrome (FMS).
Material and Method: 53 female patients and 35 healthy female controls were enrolled to our cross-sectional study. VAS, BDI and FIQ were applied to the patients. Vitamin C levels were measured by HPLC. Total Antioxidant Capacity (TAC) and Total Oxidant Status (TOS) levels were determined by Spectrophotometric Assay method.
Results: While vitamin C and TAC levels of FMS patients were significantly lower than those of the controls, OSI was significantly higher in patients (p= 0.004, p= 0.009 and p= 0.048, respectively). There was a moderate positive and significant relationship between the tender points and FIQ, (r = 0.505; p <0.001). The diagnostic performance of Vitamin C and TAC with ROC analysis were found: AUC = 0.678, p= 0.003, AUC = 0.639, p= 0.028 respectively.
Conclusion: Serum TAC and vitamin C levels decrease and OSI increases in FMS patients. It can be suggested that these three parameters can be considered as an additional tool for diagnosis of FMS.

Anahtar Kelimeler

Fibromyalgia Syndrome, TAC, OSI, Vitamin C, Chronical pain

Destekleyen Kurum

Tokat Gaziosmanpasa University Research Fund

Proje Numarası

: 2018/22

Teşekkür

We thanks to all all staff of outpatient and laboratory for their contribution.

Fibromiyalji Sendromu Tanısında Oksidatif Stres İndeksi ve C Vitamini

Öz

Amaç: FMS tanısı için spesifik bir laboratuvar belirteci yoktur ve esas olarak klinik muayeneye bağlıdır. Serum C vitamini düzeylerinin ve oksidatif stres indeksinin (OSI) Fibromiyalji Sendromu (FMS) tanısında kullanılıp kullanılamayacağını değerlendirmeyi amaçladık.
Gereç ve Yöntem: Kesitsel çalışmamıza 53 kadın hasta ve 35 sağlıklı kadın kontrol dahil edildi. Hastalara VAS, BDI ve FIQ uygulandı. C vitamini seviyeleri HPLC ile ölçüldü. Toplam Antioksidan Kapasitesi (TAC) ve Toplam Oksidan Durumu (TOS) seviyeleri Spektrofotometrik yöntemle belirlendi.
Bulgular: FMS hastalarının vitamin C ve TAC düzeyleri kontrollere göre anlamlı olarak düşük iken, hastalarda OSİ anlamlı olarak daha yüksekti (sırasıyla p= 0,004, p= 0,009 ve p= 0,048). Hassas noktalar ile FIQ arasında orta düzeyde pozitif ve anlamlı bir ilişki vardı (r = 0,505; p <0,001). ROC analizi ile Vitamin C ve TAC'nin tanısal performansı sırasıyla AUC = 0,678, p= 0,003 ve AUC = 0,639, p= 0,028 olarak bulundu.
Sonuç: FMS hastalarında serum TAC ve vitamin C seviyeleri düşmekte ve OSİ artmaktadır. Bu üç parametrenin FMS tanısı için ek bir araç olarak düşünülebileceği önerilebilir.

Anahtar Kelimeler

Fibromiyalji Sendromu, TAC, OSI, C Vitamini, Kronik ağrı

Proje Numarası

: 2018/22

Kaynakça

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