Prolonged Response with Enzalutamide in a Prostate Cancer Patient on Hemodialysis

Öz

Current therapies in oncology that offer a longer and better quality of life are leading to more cases where cancer and chronic diseases coexist. Enzalutamide, a second-generation anti-androgen agent, was approved by the US Food and Drug Administration (FDA) in 2012 for the treatment of metastatic castration-resistant prostate cancer (mCRPC). There is no series with many patients on the use of enzalutamide in patients with end-stage renal disease (ESRD). We present a patient diagnosed with mCRPC who was followed up with enzalutamide treatment for about 5 years after progression with docetaxel and who was on hemodialysis 3 days a week.

Anahtar Kelimeler

• Enzalutamide
• prostate cancer
• renal failure

Hemodiyalize Giren Prostat Kanserli Hastada Enzalutamid ile Uzun Süreli Yanıt

Öz

Onkolojide daha uzun ve kaliteli bir yaşam sunan güncel tedaviler, kanser ve kronik hastalıkların bir arada görüldüğü vakaların artmasına neden olmaktadır. İkinci nesil bir anti-androjen ajan olan enzalutamid, metastatik kastrasyona dirençli prostat kanseri (mCRPC) tedavisi için 2012 yılında ABD Gıda ve İlaç Dairesi (FDA) tarafından onaylanmıştır. Son dönem böbrek hastalığı (SDBH) olan hastalarda enzalutamid kullanımına ilişkin çok sayıda hasta içeren bir seri bulunmamaktadır. Bu çalışmada, dosetaksel ile progresyon sonrası yaklaşık 5 yıldır enzalutamid tedavisi ile takip edilen ve haftada 3 gün hemodiyalize giren mCRPC tanılı bir hastayı sunuyoruz.

Anahtar Kelimeler

• Enzalutamid
• prostat kanseri
• böbrek yetmezliği

Kaynakça

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