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An Analysis of Thyroid Fine Needle Aspiration Biopsy Results According to the Bethesda System for Reporting Thyroid Cytopathology: A Cross-Sectional Retrospective Study

Yıl 2023, Cilt: 13 Sayı: 2, 221 - 224, 22.03.2023
https://doi.org/10.16899/jcm.1239230

Öz

Background/Aims: Thyroid fine needle aspiration biopsy (TFNAB) is an effective and convenient evaluation method. It is the gold standard in preoperative evaluation. The Bethesda System for Reporting Thyroid Cytopathology is a standardized evaluation system that has been widely used all over the world. In this study, we aimed to investigate the compatibility of the TFNAB results, which we evaluated according to the Bethesda System for Reporting Thyroid Cytopathology.
Methods: The data of 333(236 female, 97 male) patients, who underwent TFNAB between January 2020 and January 2022, were collected retrospectively. Their Bethesda categories, ages, and gender characteristics were recorded.
Results: The mean age for the 333 patients included in the study was 46.46 ± 14.53 for the female patients and 50.19 ± 10.06 for the male patients. When all patients were examined, Nondiagnostic (B1), Benign (B2)were the most common cytologies. While benign cytology was observed at an earlier age, the suspicion of malignancy or the incidence of malignant cytology increased as the mean age of the patients increased.
Conclusion: The Bethesda System for Reporting Thyroid Cytopathology is a widely accepted and reliable benchmark around the world in the evaluation phase of the cytopathological examination. In this study, we examined the cytopathological evaluation results of the patients who underwent thyroid FNAB at our center according to the Bethesda System for Reporting Thyroid Cytopathology. In terms of diagnostic cytology, we recommend aultrasonography-guided biopsy performed by an experienced clinician.

Kaynakça

  • 1. Dean DS, Gharib H. Epidemiology of thyroid nodules. Best Pract Res Clin Endocrinol Metab 2008;22(6):901-11. 2. Haberal AN, Toru S, Ozen O, Arat Z, Bilezikçi B. Diagnostic pitfalls in the evaluation of fine needle aspiration cytology of the thyroid:correlation with histopathology in 260 cases. Cytopathology 2009;20(2):103-8.
  • 3. Shi Y, Ding X, Klein M, et al. Thyroid fine-needle aspiration with atypia of undetermined significance:a necessary or optional category?. Cancer 2009;117(5):298-304.
  • 4. Bongiovanni M, Spitale A, Faquin WC, Mazzucchelli L, Baloch ZW. The Bethesda System for Reporting Thyroid Cytopathology:a meta-analysis. Acta Cytol 2012;56(4):333-9.
  • 5. Akkaş Akgün G, Aslan F. The Role of Fine Needle Aspiration Biopsy with Bethesda System in the Evaluation of Thyroid Nodules. Anatolian Clinic the Journal of Medical Sciences 2021;26(1):23-30.
  • 6. La Rosa GL, Belfiore A, Giuffrida D, et al. Evaluation of the fine needle aspiration biopsy in the preoperative selection of cold thyroid nodules. Cancer. 1991;67(8):2137-41.
  • 7. Cibas ES, Ali SZ. The 2017 Bethesda System for Reporting Thyroid Cytopathology. Thyroid 2017;27(11):1341-6.
  • 8. Haugen BR, Alexander EK, Bible KC, et al 2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer:The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer. Thyroid 2016;26(1):1-133.
  • 9. Koç AM, Adibelli ZH, Erkul Z, Sahin Y. Evaluation of Fine Needle Aspiration Biopsy (FNAB) Results in Macrocalcified Thyroid Nodules. Tepecik Eğit Hast Derg 2021;31(1):103-9.
  • 10. Theoharis CG, Schofield KM, Hammers L, Udelsman R, Chhieng DC. The Bethesda thyroid fine-needle aspiration classification system:year 1 at an academic institution. Thyroid 2009;19(11):1215-23.
  • 11. Luu MH, Fischer AH, Pisharodi L, Owens CL. Improved preoperative definitive diagnosis of papillary thyroid carcinoma in FNAs prepared with both ThinPrep and conventional smears compared with FNAs prepared with ThinPrep alone. Cancer Cytopathol 2011;119(1):68-73.
  • 12.Nayar R, Ivanovic M. The indeterminate thyroid fine-needle aspiration:experience from an academic center using terminology similar to that proposed in the 2007 National Cancer Institute Thyroid Fine Needle Aspiration State of the Science Conference. Cancer 2009;117(3):195-202.
  • 13. Ocak S, Bük ÖF, Yemez K. Results of The Bethesda Classification in Patients Undergoing Thyroidectomy-a Single Institute Experience. Eur Arc Med Res 2019; 35(2):71-6.
  • 14. Sinna EA, Ezzat N. Diagnostic accuracy of fine needle aspiration cytology in thyroid lesions. J Egypt Natl Canc Inst 2012;24(2):63-70.
  • 15. Gharib H. Fine-needle aspiration biopsy of thyroid nodules:advantages, limitations, and effect. Mayo Clin Proc. 1994;69(1):44-9.

Tiroid İnce İğne Aspirasyon Biyopsi Sonuçlarının Tiroid Sitopatolojisini Raporlamak İçin Bethesda Sistemine Göre Analizi: Kesitsel Retrospektif Bir Çalışma

Yıl 2023, Cilt: 13 Sayı: 2, 221 - 224, 22.03.2023
https://doi.org/10.16899/jcm.1239230

Öz

Amaç: Tiroidin ince iğne aspirasyon biyopsisi etklili ve kullanışıl bir değerlendirme yöntemidir. Preoperatif değerlendirmede altın standarttır. Tiroid sitopatolojisini raporlamak için Bethesda Sistemi, tüm dünyada yaygın olarak kullanılan standartlaştırılmış bir değerlendirme sistemidir. Bu çalışmada Bethesda Sistemi’ ne göre değerlendirdiğimiz ince iğne aspirasyon biyopsisi sonuçlarının uyumluluğunu araştırmayı amaçladık.
Gereç ve Yöntemler: Ocak 2020-Ocak 2022 tarihleri arasında ince iğne aspirasyon biyopsisi uygulanan 333 (236 kadın, 97 erkek) hastanın verileri geriye dönük olarak toplandı. Bethesda kategorileri, yaşları ve cinsiyet özellikleri kaydedildi.
Bulgular: Çalışmaya alınan 333 hastanın yaş ortalaması kadın hastalarda 46,46±14,53, erkekhastalarda 50,19±10,06 idi. Tüm hastalar incelendiğinde Non diagnostic (B1), Benign (B2) en sık görülen sitolojilerdi. Benign sitoloji daha erken yaşlarda görülürken hastaların yaş ortalaması arttıkça malignite şüphesi veya malign sitoloji görülme sıklığı artmaktaydı.
SonuçTiroid sitolojisini raporlamak için Bethesda Sistemi sitopatolojik incelemenin değerlendirme aşamasında dünya çapında yaygın olarak kabul gören güvenilir bir kriterdir. Bu çalışmada merkezimizde ince iğne aspirasyon biyopsisi uygulanan hastaların sitopatolojik değerlendirme sonuçlarını Bethesda Sistemi’göre inceledik. Tanısal sitoloji açısından deneyimli bir klinisyen tarafından alınan ultrasonografi eşliğinde biyopsi yapılmasını öneriyoruz.

Kaynakça

  • 1. Dean DS, Gharib H. Epidemiology of thyroid nodules. Best Pract Res Clin Endocrinol Metab 2008;22(6):901-11. 2. Haberal AN, Toru S, Ozen O, Arat Z, Bilezikçi B. Diagnostic pitfalls in the evaluation of fine needle aspiration cytology of the thyroid:correlation with histopathology in 260 cases. Cytopathology 2009;20(2):103-8.
  • 3. Shi Y, Ding X, Klein M, et al. Thyroid fine-needle aspiration with atypia of undetermined significance:a necessary or optional category?. Cancer 2009;117(5):298-304.
  • 4. Bongiovanni M, Spitale A, Faquin WC, Mazzucchelli L, Baloch ZW. The Bethesda System for Reporting Thyroid Cytopathology:a meta-analysis. Acta Cytol 2012;56(4):333-9.
  • 5. Akkaş Akgün G, Aslan F. The Role of Fine Needle Aspiration Biopsy with Bethesda System in the Evaluation of Thyroid Nodules. Anatolian Clinic the Journal of Medical Sciences 2021;26(1):23-30.
  • 6. La Rosa GL, Belfiore A, Giuffrida D, et al. Evaluation of the fine needle aspiration biopsy in the preoperative selection of cold thyroid nodules. Cancer. 1991;67(8):2137-41.
  • 7. Cibas ES, Ali SZ. The 2017 Bethesda System for Reporting Thyroid Cytopathology. Thyroid 2017;27(11):1341-6.
  • 8. Haugen BR, Alexander EK, Bible KC, et al 2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer:The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer. Thyroid 2016;26(1):1-133.
  • 9. Koç AM, Adibelli ZH, Erkul Z, Sahin Y. Evaluation of Fine Needle Aspiration Biopsy (FNAB) Results in Macrocalcified Thyroid Nodules. Tepecik Eğit Hast Derg 2021;31(1):103-9.
  • 10. Theoharis CG, Schofield KM, Hammers L, Udelsman R, Chhieng DC. The Bethesda thyroid fine-needle aspiration classification system:year 1 at an academic institution. Thyroid 2009;19(11):1215-23.
  • 11. Luu MH, Fischer AH, Pisharodi L, Owens CL. Improved preoperative definitive diagnosis of papillary thyroid carcinoma in FNAs prepared with both ThinPrep and conventional smears compared with FNAs prepared with ThinPrep alone. Cancer Cytopathol 2011;119(1):68-73.
  • 12.Nayar R, Ivanovic M. The indeterminate thyroid fine-needle aspiration:experience from an academic center using terminology similar to that proposed in the 2007 National Cancer Institute Thyroid Fine Needle Aspiration State of the Science Conference. Cancer 2009;117(3):195-202.
  • 13. Ocak S, Bük ÖF, Yemez K. Results of The Bethesda Classification in Patients Undergoing Thyroidectomy-a Single Institute Experience. Eur Arc Med Res 2019; 35(2):71-6.
  • 14. Sinna EA, Ezzat N. Diagnostic accuracy of fine needle aspiration cytology in thyroid lesions. J Egypt Natl Canc Inst 2012;24(2):63-70.
  • 15. Gharib H. Fine-needle aspiration biopsy of thyroid nodules:advantages, limitations, and effect. Mayo Clin Proc. 1994;69(1):44-9.
Toplam 14 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Kurumları Yönetimi
Bölüm Orjinal Araştırma
Yazarlar

Songül Demir 0000-0002-0616-7085

Bilal Sızer 0000-0003-2604-5015

Erken Görünüm Tarihi 23 Ocak 2023
Yayımlanma Tarihi 22 Mart 2023
Kabul Tarihi 22 Şubat 2023
Yayımlandığı Sayı Yıl 2023 Cilt: 13 Sayı: 2

Kaynak Göster

AMA Demir S, Sızer B. An Analysis of Thyroid Fine Needle Aspiration Biopsy Results According to the Bethesda System for Reporting Thyroid Cytopathology: A Cross-Sectional Retrospective Study. J Contemp Med. Mart 2023;13(2):221-224. doi:10.16899/jcm.1239230