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Human Papillomavirus aşısı nereye koşuyor? Derleme

Yıl 2024, Cilt: 14 Sayı: 5, 280 - 285, 25.09.2024

Öz

DNA onkojenik virüsleri arasında kutanöz ve mukozal yüzeylerde epitel proliferasyona neden olan Human papillomavirus bulunur. Human papillomavirus, cinsel yolla bulaşan en yaygın enfeksiyondur. Cilt veya mukoza arasındaki temas yoluyla yayılır, ayrıca kutanöz veya mukozal hasar yoluyla vücuda girer. Doğum sırasında anneden bebeğe dikey geçiş olasılığı vardır ancak, nadirdir. Genellikle asemptomatik olmasına ve bağışıklık sistemi tarafından kolayca bertaraf edilmesine rağmen kansere neden olabilir. Baş ve boyun mukozal bölgeleri, servikal ve anogenital bölgelerin kanserleri Human papillomavirus ile ilişkili kötü huylu lezyonlara örnektir. Ayrıca rekurren respiratuvar papillomatozis ve ano-genital siğiller gibi benign rahatsızlıklarla da bağlantılıdır. Hem erkekler hem de kadınlar yaşamları boyunca en az bir kez enfeksiyona yakalanma konusunda eşit riske sahiptir. Human papillomavirus’e karşı en önemli korunma yöntemleri eğitim ve aşılamadır. Birkaç on yıl içinde, etkili ulusal aşılama programları olan ülkelerin serviks kanserini ortadan kaldıracağı tahmin ediliyor. Serviks kanseri, sistematik tarama ve bağışıklama programları olmayan az gelişmiş ülkelerde önde gelen bir morbidite ve mortalite kaynağı olmaya devam etmektedir. Türkiye'de serviks kanseri taraması rutin bir işlemdir ve Sağlık Bakanlığı tarafından ulusal aşılama takvimine Human papillomavirus aşısını dahil etmek için çalışmalar sürmektedir. Bu inceleme, evrensel Human papillomavirus aşılama kapsamına ulaşmada karşılaşılan zorluklardan bazılarını ve dolayısıyla serviks kanserinin ortadan kaldırılmasını tartışmanın yanı sıra, Human papillomavirus aşısının etkinliği ve güvenliği konusunda farkındalığı artırmayı amaçlamaktadır.

Kaynakça

  • 1. Garolla A, Graziani A, Grande G, Ortolani C, Ferlin A. HPV-related diseases in male patients: An underestimated conundrum. J Endocrinol Invest, 2024;47(2),261-74.
  • 2. Petca A, Borislavschi A, Zvanca ME, Petca RC, Sandru F, Dumitrascu MC. Non-sexual HPV transmission and role of vaccination for a better future. Exp Ther Med, 2020;20(6),1.
  • 3. Filipović N, Tomas D, Buljan M. Flat Warts (Verrucae Planae) Confined to the Pigment of a Tattoo: A Rare Tattoo-associated Complication. Acta Dermatovenerol Croat, 2022;31(2),113-4.
  • 4. Stelzle D, Tanaka LF, Lee KK, et al. Estimates of the global burden of cervical cancer associated with HIV. The lancet global health, 2021;9(2),161-9.
  • 5. Vega RBM, Balogun OD, Ishaq OF, Bray F, Ginsburg O, Formenti S. Estimating child mortality associated with maternal mortality from breast and cervical cancer. Cancer. 2018;125(1),109-17.
  • 6. Kiracılar E, Koçak, DY. The effects of health literacy on early diagnosis behaviors of breast and cervical cancer in women aged 18-65. J Contemp Med, 2023;13(3),410-7.
  • 7. Anna Szymonowicz K, Chen J. Biological and clinical aspects of HPV-related cancers. Cancer Biol Med. 2020;17,864–8.
  • 8. WHO: Weekly epidemiological record Relevé épidémiologique hebdomadaire. Wkly Epidemiol Rec, 2022;97,645-72. Available from: https://iris.who.int/bitstream/handle/10665/365350/WER9750-eng-fre.pdf?sequence=1
  • 9. Abramowitz L, Lacau Saint Guily J, Moyal-Barracco M, Bergeron C, Borne H, Dahlab A, et al. Epidemiological and economic burden of potentially HPV-related cancers in France. PLoS One, 2018;13(9).
  • 10. Janiszewska J, Kostrzewska-Poczekaj M, Wierzbicka M, Brenner JC, Giefing M. HPV-driven oncogenesis—much more than the E6 and E7 oncoproteins. J Applied Genetics, 2024;1-9.
  • 11. Kimberlin DW, Banerjee R, Barnett ED, Lynfield R, Sawyer MH. Red Book: 2024–2027 Report of the Committee on Infectious Diseases. 33th ed; 2024-2027.
  • 12. Wang R, Huang H, Yu C, Li X, Wang Y, Xie L. Current status and future directions for the development of human papillomavirus vaccines. Front Immunol, 2024;15,1362770.
  • 13. Penile warts.jpg, 2020. Available from: https://commons.wikimedia.org/wiki/File:Penile_warts.jpg
  • 14. Ntanasis-Stathopoulos I, Kyriazoglou A, Liontos M, Dimopoulos MA, Gavriatopoulou M. Current trends in the management and prevention of human papillomavirus (HPV) infection. J buon, 2020;25(3),1281-5.
  • 15. Ciavattini A, Marconi C, Giannella L, Delli Carpini G, Sopracordevole F, Di Giuseppe J. The impact of 9-valent HPV vaccination on couple infertility prevention: a comprehensive review. Front Med, 2021;8, 700792.
  • 16. Foresta C, Garolla A, Parisi S, et al. HPV prophylactic vaccination in males improves the clearance of semen infection. J EBioM 2(10);2015,1487-93.
  • 17. Seedat, RY. Juvenile-onset recurrent respiratory papillomatosis diagnosis and management–a developing country review. Pediatric health, medicine and therapeutics, 2020;39-46.
  • 18. Szymonowicz KA, Chen J. Biological and clinical aspects of HPV-related cancers. Cancer biol med, 2020;17(4),864.
  • 19. Republic of Turkey Ministry of Health, General Directorate of Public Health, Cancer Department, 16 May 2023. Available from: https://hsgm.saglik.gov.tr/tr/haberler/ocak-ay%C4%B1-rahim-a%C4%9Fz%C4%B1-serviks-kanseri-fark%C4%B1ndal%C4%B1k-ay%C4%B1.html
  • 20. Kamolratanakul S, Pitisuttithum P. Human papillomavirus vaccine efficacy and effectiveness against cancer. Vaccines. 2021;9(12),1413 doi: 10.3390/vaccines9121413
  • 21. Guide to introducing HPV vaccine into national immunization programmes: WHO; 2016. Available: https://apps.who.int/iris/bitstream/handle/10665/253123/9789241549769-eng.pdf?sequence=1&isAllowed=y
  • 22. Illah O, Olaitan A. Updates on HPV vaccination. Diagnostics. 2023;13(2),243.
  • 23. Annex I Summary of product characteristics. Available from: https https://www.ema.europa.eu/en/documents/product-information/gardasil-epar-product-information_en.pdf
  • 24. Akalın, A. Human Papillomavirus (HPV) Enfeksiyonu ve HPV aşısında güncel yaklaşımlar. Androl Bul, 2022;24(2).
  • 25. Annex I Summary of product characteristics. Available from: https://www.ema.europa.eu/en/documents/product-information/gardasil-9-epar-product-information_en.pdf
  • 26. Cervarix, Available from: https://titck.gov.tr/storage/Archive/2022/kubKtAttachments/CERVARX0.5MLIMENJEKSYONNSSP..KUL.HAZ.ENJ.KTTEMZ_9a79eec9-f23b-452a-b56d-2902e2b3269a.pdf
  • 27. WHO updates recommendations on HPV vaccination schedule, 20 December 2022. Available from: https://www.who.int/news/item/20-12-2022-WHO-updates-recommendations-on-HPV-vaccination-schedule
  • 28. Petrosky E, Bocchini Jr JA, Hariri S, Chesson H, Curtis CR, Saraiya M, et al. Use of 9-valent human papillomavirus (HPV) vaccine: updated HPV vaccination recommendations of the advisory committee on immunization practices. Morbidity and Mortality Weekly Report, 2015; 64(11), 300. Available from: https://www.cdc.gov/mmwr/preview/mmwrhtml/mm6411a3.htm
  • 29. Centers for Disease Control and Prevention. Latex in vaccine packaging. 2016. Available from: https://web.archive.org/web/20100413182924/http://www.cdc.gov/vaccines/pubs/pinkbook/downloads/appendices/B/latex-table.pdf
  • 30. Markowitz LE, Dunne EF, Saraiya M, Chesson HW, Curtis CR, Gee J, Unger ER. Human papillomavirus vaccination: recommendations of the Advisory Committee on Immunization Practices (ACIP). Morbidity and Mortality Weekly Report: Recommendations and Reports, 2014;63(5),1-30. Available from: https://www.cdc.gov/mmwr/preview/mmwrhtml/rr6305a1.htm
  • 31. CDC. HPV Vaccine Safety and Effectiveness Data [updated July 9, 2024]. Available from: https://www.cdc.gov/hpv/hcp/vaccination-considerations/safety-and-effectiveness-data.html?CDC_AAref_Val=https://www.cdc.gov/hpv/hcp/vaccine-safety-data.html
  • 32. Questions about HPV Vaccine Safety: CDC; Erişim: 09.09.2023, https://www.cdc.gov/vaccinesafety/vaccines/hpv/hpv-safety-faqs.html
  • 33. WHO HPV vaccine included in national immunozation programme [updated 2024]. Available from: https://app.powerbi.com/view?r=eyJrIjoiNDIxZTFkZGUtMDQ1Ny00MDZkLThiZDktYWFlYTdkOGU2NDcwIiwidCI6ImY2MTBjMGI3LWJkMjQtNGIzOS04MTBiLTNkYzI4MGFmYjU5MCIsImMiOjh9
  • 34. Laurent JS, Luckett R, Feldman S. HPV vaccination and the effects on rates of HPV-related cancers. Current problems in cancer, 2018;42(5),493-506.
  • 35. Shapiro GK. HPV vaccination: an underused strategy for the prevention of cancer. Current Oncology, 2022;29(5), 3780-92.
  • 36. Bruni L, Saura-Lázaro A, Montoliu A. HPV vaccination introduction worldwide and WHO and UNICEF estimates of national HPV immunization coverage 2010–2019. Preventive medicine, 2021;144,106399.
  • 37. TC. Sağlık Bakanlığı. Genişletilmiş Bağışıklama Programı (GBP). Available from: https://covid19asi.saglik.gov.tr/TR-77803/genisletilmis-bagisiklama-programi-gbp.html
  • 38. Gallagher KE, LaMontagne DS, Watson-Jones D. Status of HPV vaccine introduction and barriers to country uptake. Vaccine. 2018;36(32),4761-67.
  • 39. Semerci H, Yıldız M. Aşılama konulu kamu politikalarının karşılaştırmalı bir analizi. Hacettepe Üniversitesi İktisadi ve İdari Bilimler Fakültesi Dergisi, 2023;41(1), 62-84.

Where is the Human Papillomavirus vaccine heading? A Review

Yıl 2024, Cilt: 14 Sayı: 5, 280 - 285, 25.09.2024

Öz

DNA oncogenic viruses include Human papillomavirus that causes epithelial proliferation at cutaneous and mucosal surfaces. Human papillomavirus is the most common sexually transmitted infection. It spreads through contact between the skin or mucosa also enters the body through cutaneous or mucosal damage. Vertical transfer from mother to baby during birthing is a possibility but is uncommon. Human papillomavirus infection can result in cancer even though it is usually asymptomatic and readily treated by the immune system. Cancers of the head and neck mucosal regions, cervical, and anogenital areas are examples of malignant lesions associated with Human papillomavirus. It is also linked to non-cancerous disorders such recurrent respiratory papillomatosis and ano-genital warts. Globally, both men and women have an equal chance of contracting the infection at least once in their lifetime. The most important protection methods against Human papillomavirus are education and immunization. It is estimated that within a few decades, countries with effective national HPV vaccination programs will have eliminated cervical cancer. Cervical cancer remains a leading source of morbidity and mortality in underdeveloped countries without systematic screening and HPV immunization programs. In Turkey, cervical cancer screening is a routine procedure, and research is ongoing by the Ministry of Health to include Human papillomavirus vaccine in the national immunization schedule. In addition to discussing some of the challenges faced in achieving universal Human papillomavirus vaccination coverage and, consequently, the eradication of cervical cancer, this review seeks to increase awareness of efficiency, and safety of the Human papillomavirus vaccine.

Kaynakça

  • 1. Garolla A, Graziani A, Grande G, Ortolani C, Ferlin A. HPV-related diseases in male patients: An underestimated conundrum. J Endocrinol Invest, 2024;47(2),261-74.
  • 2. Petca A, Borislavschi A, Zvanca ME, Petca RC, Sandru F, Dumitrascu MC. Non-sexual HPV transmission and role of vaccination for a better future. Exp Ther Med, 2020;20(6),1.
  • 3. Filipović N, Tomas D, Buljan M. Flat Warts (Verrucae Planae) Confined to the Pigment of a Tattoo: A Rare Tattoo-associated Complication. Acta Dermatovenerol Croat, 2022;31(2),113-4.
  • 4. Stelzle D, Tanaka LF, Lee KK, et al. Estimates of the global burden of cervical cancer associated with HIV. The lancet global health, 2021;9(2),161-9.
  • 5. Vega RBM, Balogun OD, Ishaq OF, Bray F, Ginsburg O, Formenti S. Estimating child mortality associated with maternal mortality from breast and cervical cancer. Cancer. 2018;125(1),109-17.
  • 6. Kiracılar E, Koçak, DY. The effects of health literacy on early diagnosis behaviors of breast and cervical cancer in women aged 18-65. J Contemp Med, 2023;13(3),410-7.
  • 7. Anna Szymonowicz K, Chen J. Biological and clinical aspects of HPV-related cancers. Cancer Biol Med. 2020;17,864–8.
  • 8. WHO: Weekly epidemiological record Relevé épidémiologique hebdomadaire. Wkly Epidemiol Rec, 2022;97,645-72. Available from: https://iris.who.int/bitstream/handle/10665/365350/WER9750-eng-fre.pdf?sequence=1
  • 9. Abramowitz L, Lacau Saint Guily J, Moyal-Barracco M, Bergeron C, Borne H, Dahlab A, et al. Epidemiological and economic burden of potentially HPV-related cancers in France. PLoS One, 2018;13(9).
  • 10. Janiszewska J, Kostrzewska-Poczekaj M, Wierzbicka M, Brenner JC, Giefing M. HPV-driven oncogenesis—much more than the E6 and E7 oncoproteins. J Applied Genetics, 2024;1-9.
  • 11. Kimberlin DW, Banerjee R, Barnett ED, Lynfield R, Sawyer MH. Red Book: 2024–2027 Report of the Committee on Infectious Diseases. 33th ed; 2024-2027.
  • 12. Wang R, Huang H, Yu C, Li X, Wang Y, Xie L. Current status and future directions for the development of human papillomavirus vaccines. Front Immunol, 2024;15,1362770.
  • 13. Penile warts.jpg, 2020. Available from: https://commons.wikimedia.org/wiki/File:Penile_warts.jpg
  • 14. Ntanasis-Stathopoulos I, Kyriazoglou A, Liontos M, Dimopoulos MA, Gavriatopoulou M. Current trends in the management and prevention of human papillomavirus (HPV) infection. J buon, 2020;25(3),1281-5.
  • 15. Ciavattini A, Marconi C, Giannella L, Delli Carpini G, Sopracordevole F, Di Giuseppe J. The impact of 9-valent HPV vaccination on couple infertility prevention: a comprehensive review. Front Med, 2021;8, 700792.
  • 16. Foresta C, Garolla A, Parisi S, et al. HPV prophylactic vaccination in males improves the clearance of semen infection. J EBioM 2(10);2015,1487-93.
  • 17. Seedat, RY. Juvenile-onset recurrent respiratory papillomatosis diagnosis and management–a developing country review. Pediatric health, medicine and therapeutics, 2020;39-46.
  • 18. Szymonowicz KA, Chen J. Biological and clinical aspects of HPV-related cancers. Cancer biol med, 2020;17(4),864.
  • 19. Republic of Turkey Ministry of Health, General Directorate of Public Health, Cancer Department, 16 May 2023. Available from: https://hsgm.saglik.gov.tr/tr/haberler/ocak-ay%C4%B1-rahim-a%C4%9Fz%C4%B1-serviks-kanseri-fark%C4%B1ndal%C4%B1k-ay%C4%B1.html
  • 20. Kamolratanakul S, Pitisuttithum P. Human papillomavirus vaccine efficacy and effectiveness against cancer. Vaccines. 2021;9(12),1413 doi: 10.3390/vaccines9121413
  • 21. Guide to introducing HPV vaccine into national immunization programmes: WHO; 2016. Available: https://apps.who.int/iris/bitstream/handle/10665/253123/9789241549769-eng.pdf?sequence=1&isAllowed=y
  • 22. Illah O, Olaitan A. Updates on HPV vaccination. Diagnostics. 2023;13(2),243.
  • 23. Annex I Summary of product characteristics. Available from: https https://www.ema.europa.eu/en/documents/product-information/gardasil-epar-product-information_en.pdf
  • 24. Akalın, A. Human Papillomavirus (HPV) Enfeksiyonu ve HPV aşısında güncel yaklaşımlar. Androl Bul, 2022;24(2).
  • 25. Annex I Summary of product characteristics. Available from: https://www.ema.europa.eu/en/documents/product-information/gardasil-9-epar-product-information_en.pdf
  • 26. Cervarix, Available from: https://titck.gov.tr/storage/Archive/2022/kubKtAttachments/CERVARX0.5MLIMENJEKSYONNSSP..KUL.HAZ.ENJ.KTTEMZ_9a79eec9-f23b-452a-b56d-2902e2b3269a.pdf
  • 27. WHO updates recommendations on HPV vaccination schedule, 20 December 2022. Available from: https://www.who.int/news/item/20-12-2022-WHO-updates-recommendations-on-HPV-vaccination-schedule
  • 28. Petrosky E, Bocchini Jr JA, Hariri S, Chesson H, Curtis CR, Saraiya M, et al. Use of 9-valent human papillomavirus (HPV) vaccine: updated HPV vaccination recommendations of the advisory committee on immunization practices. Morbidity and Mortality Weekly Report, 2015; 64(11), 300. Available from: https://www.cdc.gov/mmwr/preview/mmwrhtml/mm6411a3.htm
  • 29. Centers for Disease Control and Prevention. Latex in vaccine packaging. 2016. Available from: https://web.archive.org/web/20100413182924/http://www.cdc.gov/vaccines/pubs/pinkbook/downloads/appendices/B/latex-table.pdf
  • 30. Markowitz LE, Dunne EF, Saraiya M, Chesson HW, Curtis CR, Gee J, Unger ER. Human papillomavirus vaccination: recommendations of the Advisory Committee on Immunization Practices (ACIP). Morbidity and Mortality Weekly Report: Recommendations and Reports, 2014;63(5),1-30. Available from: https://www.cdc.gov/mmwr/preview/mmwrhtml/rr6305a1.htm
  • 31. CDC. HPV Vaccine Safety and Effectiveness Data [updated July 9, 2024]. Available from: https://www.cdc.gov/hpv/hcp/vaccination-considerations/safety-and-effectiveness-data.html?CDC_AAref_Val=https://www.cdc.gov/hpv/hcp/vaccine-safety-data.html
  • 32. Questions about HPV Vaccine Safety: CDC; Erişim: 09.09.2023, https://www.cdc.gov/vaccinesafety/vaccines/hpv/hpv-safety-faqs.html
  • 33. WHO HPV vaccine included in national immunozation programme [updated 2024]. Available from: https://app.powerbi.com/view?r=eyJrIjoiNDIxZTFkZGUtMDQ1Ny00MDZkLThiZDktYWFlYTdkOGU2NDcwIiwidCI6ImY2MTBjMGI3LWJkMjQtNGIzOS04MTBiLTNkYzI4MGFmYjU5MCIsImMiOjh9
  • 34. Laurent JS, Luckett R, Feldman S. HPV vaccination and the effects on rates of HPV-related cancers. Current problems in cancer, 2018;42(5),493-506.
  • 35. Shapiro GK. HPV vaccination: an underused strategy for the prevention of cancer. Current Oncology, 2022;29(5), 3780-92.
  • 36. Bruni L, Saura-Lázaro A, Montoliu A. HPV vaccination introduction worldwide and WHO and UNICEF estimates of national HPV immunization coverage 2010–2019. Preventive medicine, 2021;144,106399.
  • 37. TC. Sağlık Bakanlığı. Genişletilmiş Bağışıklama Programı (GBP). Available from: https://covid19asi.saglik.gov.tr/TR-77803/genisletilmis-bagisiklama-programi-gbp.html
  • 38. Gallagher KE, LaMontagne DS, Watson-Jones D. Status of HPV vaccine introduction and barriers to country uptake. Vaccine. 2018;36(32),4761-67.
  • 39. Semerci H, Yıldız M. Aşılama konulu kamu politikalarının karşılaştırmalı bir analizi. Hacettepe Üniversitesi İktisadi ve İdari Bilimler Fakültesi Dergisi, 2023;41(1), 62-84.
Toplam 39 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Bulaşıcı Hastalıklar
Bölüm Derleme
Yazarlar

Burcu Parlak 0000-0002-1222-8761

Yayımlanma Tarihi 25 Eylül 2024
Gönderilme Tarihi 31 Temmuz 2024
Kabul Tarihi 11 Eylül 2024
Yayımlandığı Sayı Yıl 2024 Cilt: 14 Sayı: 5

Kaynak Göster

AMA Parlak B. Where is the Human Papillomavirus vaccine heading? A Review. J Contemp Med. Eylül 2024;14(5):280-285.