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Akut Romatizmal Ateşli Hastaların Değerlendirilmesi: 13 Yıllık Tek Merkez Deneyimi

Yıl 2025, Cilt: 15 Sayı: 1, 1 - 7

Öz

Amaç: Türkiye'de akut romatizmal ateşin sıklığına ilişkin veriler sınırlıdır. Çalışmanın amacı Doğu Karadeniz Bölgesi'nde akut romatizmal ateş tanısıyla takip edilen hastaların demografik ve klinik özelliklerinin retrospektif olarak değerlendirilmesidir.
Gereç ve Yöntemler: Kliniğimizde Ocak 2005 ile Aralık 2017 tarihleri arasında akut romatizmal ateş tanısı alan hastaların demografik, klinik ve laboratuvar özellikleri arşiv kayıtlarından değerlendirildi.
Bulgular: Çalışmaya yaş ortalaması 11±3,52 yıl (26 ay-17 yıl), kadın/erkek oranı 1,38 olan 175 hasta dahil edildi. Hastalar en sık Şubat, Mayıs ve Ağustos aylarında başvurdu. En sık görülen majör bulgu kardit (%80) iken, artrit %51,4, kore ise %16 oranında görüldü. Sadece bir hastada eritema marjinatum mevcuttu. Kardit hastalarında en sık izole mitral kapak tutulumu (%54,3) görülürken, eş zamanlı mitral ve aort kapak tutulumu hastaların %30,7'sinde, izole aort kapak tutulumu ise %10 oranında saptandı. Mitral tutulumu olan üç (%2,1) hastada triküspit yetersizliği görüldü. Sekonder profilaksi ile uyumsuz olan yedi hastanın dördünde (%57,1) nüks tespit edildi. Klinik takip sırasında iki hastaya mitral ve aort kapak değişimi uygulandı. Hastalarda mortalite görülmedi.
Sonuç: Türkiye'de son yıllarda sosyo-ekonomik koşullardaki iyileşmeye rağmen akut romatizmal ateş, Doğu Karadeniz Bölgesi için önemli bir sağlık sorunu olmaya devam etmektedir.

Kaynakça

  • 1. Webb RH, Grant C, Harnden A. Acute rheumatic fever. BMJ 2015;351:h3443.
  • 2. Arvind B, Ramakrishnan S. Rheumatic Fever and Rheumatic Heart Disease in Children. Indian J Pediatr 2020;87:305-311.
  • 3. Zühlke LJ, Beaton A, Engel ME, et al. Group A Streptococcus, Acute Rheumatic Fever and Rheumatic Heart Disease: Epidemiology and Clinical Considerations. Curr Treat Options Cardiovasc Med 2017;19:15.
  • 4. Woldu B, Bloomfield GS. Rheumatic Heart Disease in the Twenty-First Century. Curr Cardiol Rep 2016;18:96. 5. Lahiri S, Sanyahumbi A. Acute Rheumatic Fever. Pediatr Rev 2021;42:221-232.
  • 6. Gewitz MH, Baltimore RS, Tani LY, et al. Revision of the Jones Criteria for the diagnosis of acute rheumatic fever in the era of Doppler echocardiography: a scientific statement from the American Heart Association [published correction appears in Circulation. 2020 Jul 28;142:e65]. Circulation 2015;131:1806-1818.
  • 7. Gürses D, Koçak G, Tutar E, Özbarlas N; Turkish ARF study group. Incidence and clinical characteristics of acute rheumatic fever in Turkey: Results of a nationwide multicentre study. J Paediatr Child Health 2021;57:1949-1954.
  • 8. Reményi B, Wilson N, Steer A, et al. World Heart Federation criteria for echocardiographic diagnosis of rheumatic heart disease--an evidence-based guideline. Nat Rev Cardiol 2012;9:297-309.
  • 9. Karthikeyan G, Guilherme L. Acute rheumatic fever [published correction appears in Lancet. 2018;392:820]. Lancet 2018;392:161-174.
  • 10. Kumar RK, Tandon R. Rheumatic fever & rheumatic heart disease: the last 50 years. Indian J Med Res 2013;137:643-658.
  • 11. de Loizaga SR, Beaton AZ. Rheumatic Fever and Rheumatic Heart Disease in the United States. Pediatr Ann 2021;50:e98-e104.
  • 12. Rising Ethnic Inequalities in Acute Rheumatic Fever and Rheumatic Heart Disease, New Zealand, 2000-2018. Emerg Infect Dis 2021;27:36-46.
  • 13. Oliver J, Osowicki J, Cordell B, Hardy M, Engelman D, Steer AC. Incidence of acute rheumatic fever and rheumatic heart disease in Melbourne, Australia from 1937 to 2013. J Paediatr Child Health 2020;56:1408-1413.
  • 14. Saraçlar M, Ertuğrul A, Özme ve Ajun A. Akut romatizmal ateş insidansı ve romatizmal kalp hastalıklarının prevalansı. Türk Kardiyoloji Dern Arş 1978;7:50-5.
  • 15. Orün UA, Ceylan O, Bilici M, Karademir S, Ocal B, Senocak F, et al. Acute rheumatic fever in the Central Anatolia Region of Turkey: a 30-year experience in a single center. Eur J Pediatr 2012;171:361-8.
  • 16. Narin N, Mutlu F, Argun M, Ozyurt A, Pamukcu O, Baykan A, et al. Incidence and clinical features of acute rheumatic fever in Kayseri, Central Anatolia, 1998-2011. Cardiol Young 2015;25:745-51.
  • 17. Tani LY, Veasy LG, Minich LL, Shaddy RE. Rheumatic fever in children younger than 5 years: is the presentation different? Pediatrics 2003;112:1065-8.
  • 18. Abdin ZH, Eissa A. Rheumatic fever and rheumatic heart disease in children below the age of 5 years in the tropics. Ann Rheum Dis 1965;24:389-91.
  • 19. Bono-Neri F. Acute Rheumatic Fever: Global Persistence of a Preventable Disease. J Pediatr Health Care 2017;31:275-284.
  • 20. Bennett J, Rentta N, Leung W, et al. Structured review of primary interventions to reduce group A streptococcal infections, acute rheumatic fever and rheumatic heart disease [published correction appears in J Paediatr Child Health. 2021;57:1155]. J Paediatr Child Health 2021;57:797-802.
  • 21. Bostan MÖ, Çil E. Bursa ilindeki çocuklarda akut romatizmal ateşin değerlendirilmesi. T Klin Kardiyoloji 2001;14:276-281.
  • 22. Teixeira AL, Vasconcelos LP, Nunes MDCP, Singer H. Sydenham's chorea: from pathophysiology to therapeutics. Expert Rev Neurother 2021;21:913-922.
  • 23. Caldas AM, Terreri MT, Moises VA, Silva CM, Len CA, Carvalho AC et al. What is the true frequency of carditis in acute rheumatic fever? A prospective clinical and Doppler blind study of 56 children with up to 60 months of follow-up evaluation. Pediatr Cardiol 2008;29:1048-53.
  • 24. Hung LC, Nadia R. A Review of Acute Rheumatic Fever and Rheumatic Heart Disease Research in Malaysia. Med J Malaysia 2016;71:79-86.
  • 25. Erdem S, Demir F, Ayana M, et al. Acute rheumatic fever in south-east of Turkey: clinical features and epidemiological evaluation of the patients over the last 25 years. Cardiol Young 2020;30:1086-1094.
  • 26. Ekici F, Kale Y, Kocabaş A. Changing face of acute rheumatic fever: our clinical observations. Anadolu Kardiyol Derg 2013;13:506-7.
  • 27. Grassi A, Fesslovà V, Carnelli V, Boati E, Dell'era L, Salice P, et al. Clinical characteristics and cardiac outcome of acute rheumatic fever in Italy in the last 15 years. Clin Exp Rheumatol 2009;27:366-72.
  • 28. Yildirim A, Aydin A, Demir T, et al. Acute rheumatic fever: a single center experience with 193 clinical cases. Minerva Pediatr 2016;68:134-142.
  • 29. Güngör Ş, Doksöz O, Fettah A, Nacaroğlu HN, Örün UA, Karademir S. Akut romatizmal ateş tanısı ile izlenen hastaların geriye dönük olarak değerlendirilmesi: Beş yıllık tek merkez deneyimi. İzmir Dr. Behçet Uz Çocuk Hast. Dergisi 2014; 4:87-96.
  • 30. Bennett J, Rentta NN, Leung W, et al. Early diagnosis of acute rheumatic fever and rheumatic heart disease as part of a secondary prevention strategy: Narrative review. J Paediatr Child Health 2021;57:1385-1390.
  • 31. Mota CC, Meira ZM, Graciano RN, Graciano FF, Araújo FD. Rheumatic Fever prevention program: long-term evolution and outcomes. Front Pediatr 2015;2:1-5.
  • 32. Bozabalı S, Mammadova A, Turan C, Sahan YO, Levent E. Akut Romatizmal Ateşe Bağlı Kardit Gelişen Hastalarda Penisilin Profilaksisinin Etkinliğinin Değerlendirilmesi. Türkiye Çocuk Hast Derg 2016;1:7-12.
  • 33. Leal MTBC, Passos LSA, Guarçoni FV, et al. Rheumatic heart disease in the modern era: recent developments and current challenges. Rev Soc Bras Med Trop 2019;52:e20180041.
  • 34. Atalay S, Tutar E, Uçar T, Topçu S, Köse SK, Doğan MT. Echocardiographic screening for rheumatic heart disease in Turkish schoolchildren. Cardiol Young. 2019;29(10):1272-1277.

Evaluation of Patients with Acute Rheumatic Fever: 13-Year Experience of a Single Center

Yıl 2025, Cilt: 15 Sayı: 1, 1 - 7

Öz

Background/Aims: Data on the frequency of acute rheumatic fever in Turkey is limited. The study aims to evaluate patients' demographic and clinical characteristics retrospectively followed up with a diagnosis of acute rheumatic fever in the Eastern Black Sea Region.
Materials and Methods: Demographic, clinical and laboratory characteristics of patients diagnosed with acute rheumatic fever in our clinic between January 2005 and December 2017 were evaluated from archival records.
Results: Included in the study were 175 patients with a mean age of 11±3.52 years (26 months–17 years), with a female/male ratio of 1.38. Patients are most frequently presented in February, May and August. Carditis was the most common (80%) major finding, while arthritis was seen in 51.4% and chorea in 16%. Erythema marginatum was present in only one patient. While isolated mitral valve involvement (54.3%) was most common in the patients with carditis, simultaneous mitral and aortic valve involvement was found in 30.7% of the patients, and isolated aortic valve involvement in 10%. Tricuspid regurgitation was seen in three (2.1%) patients with mitral involvement. Recurrence was detected in four (57.1%) of the seven patients who were incompatible with secondary prophylaxis. During clinical follow-up, two patients underwent mitral and aortic valve replacement. No mortality was observed in the patients.
Conclusion: Despite improving socio-economic conditions in Turkiye in recent years, acute rheumatic fever remains a significant health problem for the Eastern Black Sea Region.

Kaynakça

  • 1. Webb RH, Grant C, Harnden A. Acute rheumatic fever. BMJ 2015;351:h3443.
  • 2. Arvind B, Ramakrishnan S. Rheumatic Fever and Rheumatic Heart Disease in Children. Indian J Pediatr 2020;87:305-311.
  • 3. Zühlke LJ, Beaton A, Engel ME, et al. Group A Streptococcus, Acute Rheumatic Fever and Rheumatic Heart Disease: Epidemiology and Clinical Considerations. Curr Treat Options Cardiovasc Med 2017;19:15.
  • 4. Woldu B, Bloomfield GS. Rheumatic Heart Disease in the Twenty-First Century. Curr Cardiol Rep 2016;18:96. 5. Lahiri S, Sanyahumbi A. Acute Rheumatic Fever. Pediatr Rev 2021;42:221-232.
  • 6. Gewitz MH, Baltimore RS, Tani LY, et al. Revision of the Jones Criteria for the diagnosis of acute rheumatic fever in the era of Doppler echocardiography: a scientific statement from the American Heart Association [published correction appears in Circulation. 2020 Jul 28;142:e65]. Circulation 2015;131:1806-1818.
  • 7. Gürses D, Koçak G, Tutar E, Özbarlas N; Turkish ARF study group. Incidence and clinical characteristics of acute rheumatic fever in Turkey: Results of a nationwide multicentre study. J Paediatr Child Health 2021;57:1949-1954.
  • 8. Reményi B, Wilson N, Steer A, et al. World Heart Federation criteria for echocardiographic diagnosis of rheumatic heart disease--an evidence-based guideline. Nat Rev Cardiol 2012;9:297-309.
  • 9. Karthikeyan G, Guilherme L. Acute rheumatic fever [published correction appears in Lancet. 2018;392:820]. Lancet 2018;392:161-174.
  • 10. Kumar RK, Tandon R. Rheumatic fever & rheumatic heart disease: the last 50 years. Indian J Med Res 2013;137:643-658.
  • 11. de Loizaga SR, Beaton AZ. Rheumatic Fever and Rheumatic Heart Disease in the United States. Pediatr Ann 2021;50:e98-e104.
  • 12. Rising Ethnic Inequalities in Acute Rheumatic Fever and Rheumatic Heart Disease, New Zealand, 2000-2018. Emerg Infect Dis 2021;27:36-46.
  • 13. Oliver J, Osowicki J, Cordell B, Hardy M, Engelman D, Steer AC. Incidence of acute rheumatic fever and rheumatic heart disease in Melbourne, Australia from 1937 to 2013. J Paediatr Child Health 2020;56:1408-1413.
  • 14. Saraçlar M, Ertuğrul A, Özme ve Ajun A. Akut romatizmal ateş insidansı ve romatizmal kalp hastalıklarının prevalansı. Türk Kardiyoloji Dern Arş 1978;7:50-5.
  • 15. Orün UA, Ceylan O, Bilici M, Karademir S, Ocal B, Senocak F, et al. Acute rheumatic fever in the Central Anatolia Region of Turkey: a 30-year experience in a single center. Eur J Pediatr 2012;171:361-8.
  • 16. Narin N, Mutlu F, Argun M, Ozyurt A, Pamukcu O, Baykan A, et al. Incidence and clinical features of acute rheumatic fever in Kayseri, Central Anatolia, 1998-2011. Cardiol Young 2015;25:745-51.
  • 17. Tani LY, Veasy LG, Minich LL, Shaddy RE. Rheumatic fever in children younger than 5 years: is the presentation different? Pediatrics 2003;112:1065-8.
  • 18. Abdin ZH, Eissa A. Rheumatic fever and rheumatic heart disease in children below the age of 5 years in the tropics. Ann Rheum Dis 1965;24:389-91.
  • 19. Bono-Neri F. Acute Rheumatic Fever: Global Persistence of a Preventable Disease. J Pediatr Health Care 2017;31:275-284.
  • 20. Bennett J, Rentta N, Leung W, et al. Structured review of primary interventions to reduce group A streptococcal infections, acute rheumatic fever and rheumatic heart disease [published correction appears in J Paediatr Child Health. 2021;57:1155]. J Paediatr Child Health 2021;57:797-802.
  • 21. Bostan MÖ, Çil E. Bursa ilindeki çocuklarda akut romatizmal ateşin değerlendirilmesi. T Klin Kardiyoloji 2001;14:276-281.
  • 22. Teixeira AL, Vasconcelos LP, Nunes MDCP, Singer H. Sydenham's chorea: from pathophysiology to therapeutics. Expert Rev Neurother 2021;21:913-922.
  • 23. Caldas AM, Terreri MT, Moises VA, Silva CM, Len CA, Carvalho AC et al. What is the true frequency of carditis in acute rheumatic fever? A prospective clinical and Doppler blind study of 56 children with up to 60 months of follow-up evaluation. Pediatr Cardiol 2008;29:1048-53.
  • 24. Hung LC, Nadia R. A Review of Acute Rheumatic Fever and Rheumatic Heart Disease Research in Malaysia. Med J Malaysia 2016;71:79-86.
  • 25. Erdem S, Demir F, Ayana M, et al. Acute rheumatic fever in south-east of Turkey: clinical features and epidemiological evaluation of the patients over the last 25 years. Cardiol Young 2020;30:1086-1094.
  • 26. Ekici F, Kale Y, Kocabaş A. Changing face of acute rheumatic fever: our clinical observations. Anadolu Kardiyol Derg 2013;13:506-7.
  • 27. Grassi A, Fesslovà V, Carnelli V, Boati E, Dell'era L, Salice P, et al. Clinical characteristics and cardiac outcome of acute rheumatic fever in Italy in the last 15 years. Clin Exp Rheumatol 2009;27:366-72.
  • 28. Yildirim A, Aydin A, Demir T, et al. Acute rheumatic fever: a single center experience with 193 clinical cases. Minerva Pediatr 2016;68:134-142.
  • 29. Güngör Ş, Doksöz O, Fettah A, Nacaroğlu HN, Örün UA, Karademir S. Akut romatizmal ateş tanısı ile izlenen hastaların geriye dönük olarak değerlendirilmesi: Beş yıllık tek merkez deneyimi. İzmir Dr. Behçet Uz Çocuk Hast. Dergisi 2014; 4:87-96.
  • 30. Bennett J, Rentta NN, Leung W, et al. Early diagnosis of acute rheumatic fever and rheumatic heart disease as part of a secondary prevention strategy: Narrative review. J Paediatr Child Health 2021;57:1385-1390.
  • 31. Mota CC, Meira ZM, Graciano RN, Graciano FF, Araújo FD. Rheumatic Fever prevention program: long-term evolution and outcomes. Front Pediatr 2015;2:1-5.
  • 32. Bozabalı S, Mammadova A, Turan C, Sahan YO, Levent E. Akut Romatizmal Ateşe Bağlı Kardit Gelişen Hastalarda Penisilin Profilaksisinin Etkinliğinin Değerlendirilmesi. Türkiye Çocuk Hast Derg 2016;1:7-12.
  • 33. Leal MTBC, Passos LSA, Guarçoni FV, et al. Rheumatic heart disease in the modern era: recent developments and current challenges. Rev Soc Bras Med Trop 2019;52:e20180041.
  • 34. Atalay S, Tutar E, Uçar T, Topçu S, Köse SK, Doğan MT. Echocardiographic screening for rheumatic heart disease in Turkish schoolchildren. Cardiol Young. 2019;29(10):1272-1277.
Toplam 33 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Çocuk Kardiyolojisi
Bölüm Orjinal Araştırma
Yazarlar

Fatma İssi Irlayıcı 0000-0002-3182-1990

Embiya Dilber 0000-0001-6942-554X

Yayımlanma Tarihi
Gönderilme Tarihi 6 Ekim 2024
Kabul Tarihi 26 Kasım 2024
Yayımlandığı Sayı Yıl 2025 Cilt: 15 Sayı: 1

Kaynak Göster

AMA İssi Irlayıcı F, Dilber E. Evaluation of Patients with Acute Rheumatic Fever: 13-Year Experience of a Single Center. J Contemp Med. 15(1):1-7.