Mortal Complication of Kikuchi–Fujimoto Disease; Lower Gastrointestinal Bleeding, Case Presentation and Literature Review

Öz

In this report, we inform you that a patient with CFD, known as a benign disease, died due to massive lower GI bleeding. Although KFD is a benign disease, we have seen in this case that it can result in death. A 28-year-old Turkish male patient was brought to the hospital with complaints of high fever, fatigue, sweating and difficulty breathing. A cervical examination revealed that the patient had lymphadenopathy. The patient did not have any cutaneous lesions. Genital examination revealed melena. A normal cranial and abdomen, thorax CT was obtained. The patient was intubated because of respiratory failure and unstable hemodynamics. The patient developed pancytopenia as a result of blood tests. The patient died due to massive lower gastrointestinal bleeding.

Anahtar Kelimeler

• Kikuchi–Fujimoto Disease
• Lower Gastrointestinal Bleeding;
• Histiocytic Necrotizing Lymphadenitis

Kaynakça

1. 1. Fujimoto Y, Kojima Y, Yamaguchi K. Cervical subacute necrotizing lymphadenitis. A new clinicopathological entity. Naika. 1972:920– 927.
2. 2. Kikuchi M. Lymphadenitis showing focal reticulum cell hyperplasia with nuclear debris and phagocytosis: a clinicopathological study. Acta Hematol Jpn. 1972379–80.
3. 3. Kucukardali Y, Solmazgul E, Kunter E, et al. Kikuchi-Fujimoto Disease: analysis of 244 cases. Clin Rheumatol. 2007;26:50–54.
4. 4. Lee KY, Yeon YH, Lee BC (2004) Kikuchi–Fujimoto Disease with prolonged fever in children. Pediatrics 114:752–756 5. Wang TJ, Yang YH, Lin YT, Chiang BL (2004) Kikuchi– Fujimoto disease in children: clinical features and disease course. J Microbiol Immunol Infect 37:219–224)
5. 5. Chiu CF, Chow KC, Lin TY, et al. Virus infection in patients with histiocytic necrotizing lymphadenitis in Taiwan. Detection of Epstein-Barr virus, type I human T-cell lymphotropic virus, and parvovirus B19. Am J Clin Pathol. 2000;113:774–781.
6. 6. Kikuchi-Fujimoto Disease Retrospective Study of 91 Cases and Review of the Literature. Medicine (Baltimore). 2014 Nov;93(24):414
7. 7. Chen JS, Chang KC, Cheng CN, et al. Childhood hemophagocytic syndrome associated with Kikuchi’s disease. Haematologica. 2000;85:998–1000.)
8. 8. Bilateral preretinal hemorrhage associated with Kikuchi-Fujimoto disease. Am J Ophthalmol Case Rep. 2021 Jun; 22: 101041.