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Importance of Recombinant Tissue Plasminogen Activator (rt-PA) thrombolysis in hyperacute stroke patients with aphasia – A case report

Cilt: 16 Sayı: 1 28 Mart 2025
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Importance of Recombinant Tissue Plasminogen Activator (rt-PA) thrombolysis in hyperacute stroke patients with aphasia – A case report

Öz

Background: Thrombolysis in an acute stroke has been shown to have a good outcome measure in an eligible candidate. However, the benefits and effectiveness of it in acute minor stroke are still not well established. Case description: We describe a case of 35-year-old male who was presented with isolated aphasia with the total National Institutes of Health Stroke Scale of 3 out of 42. Magnetic Resonance Imaging of the brain showed a focal left middle cerebral artery territory infarction secondary to distal vessel occlusion at M4 segment distally on Diffusion-Weighted Imaging sequence which was mismatched on Fluid-Attenuated Inversion Recovery sequence. Recombined tissue plasminogen activator was administrated intravenously without any complication. The patient's condition improved gradually with positive outcome measures. Conclusion: Intravenous r-TPA can be a beneficial treatment for a subset of patients with minor stroke.

Anahtar Kelimeler

Kaynakça

  1. 1. Werner Hacke, M.D., Markku Kaste, M.D., Erich Bluhmki, Ph.D., Miroslav Brozman, M.D., Antoni Dávalos, M.D., Donata Guidetti, M.D., Vincent Larrue, M.D., Kennedy R. Lees, M.D., Zakaria Medeghri, M.D., Thomas Machnig, M.D., Dietmar Schneider, M.D., Rüdiger von Kummer, M.D., et al. Thrombolysis with Alteplase 3 to 4.5 Hours after Acute Ischemic Stroke. N Engl J Med 2008; 359:1317-1329
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  3. 3. Urs Fischer, Adrian Baumgartner, Marcel Arnold, Krassen Nedeltchev, Jan Gralla, Gian Marco De Marchis, Liliane Kappeler, Marie-Luise Mono, Caspar Brekenfeld, Gerhard Schroth, and Heinrich P. Mattle. What Is a Minor Stroke? Stroke. 2010;41:661–666
  4. 4. NIH Stroke Scale (NIHSS). NIH stroke scale International; 1999; http://www.nihstrokescale.org/.
  5. 5. Casella G, Llinas RH, Marsh EB. Isolated aphasia in the emergency department: The likelihood of ischemia is low. Clin Neurol Neurosurg. 2017 Dec;163:24-26.
  6. 6. Nesi M, Lucente G, Nencini P, Fancellu L, Inzitari D. Aphasia predicts unfavorable outcome in mild ischemic stroke patients and prompts thrombolytic treatment. J Stroke Cerebrovasc Dis. 2014 Feb;23(2):204-8.
  7. 7. Ilana Spokoyny, MD, Rema Raman, PhD, Karin Ernstrom, MS, Pooja Khatri, MD, MSc, Dawn M. Meyer, PhD, RN, FNP-C, Thomas M. Hemmen, MD, PhD, and Brett C. Meyer, MD Defining Mild Stroke: Outcomes Analysis of Treated and Untreated Mild Stroke Patients. J Stroke Cerebrovasc Dis. 2015 June ; 24(6): 1276–1281.
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Ayrıntılar

Birincil Dil

İngilizce

Konular

Acil Tıp

Bölüm

Olgu Sunumu

Yayımlanma Tarihi

28 Mart 2025

Gönderilme Tarihi

3 Aralık 2024

Kabul Tarihi

11 Şubat 2025

Yayımlandığı Sayı

Yıl 2025 Cilt: 16 Sayı: 1

Kaynak Göster

APA
Md Pauzi, A. L., & Hashim, J. (2025). Importance of Recombinant Tissue Plasminogen Activator (rt-PA) thrombolysis in hyperacute stroke patients with aphasia – A case report. Journal of Emergency Medicine Case Reports, 16(1), 34-37. https://doi.org/10.33706/jemcr.1592792
AMA
1.Md Pauzi AL, Hashim J. Importance of Recombinant Tissue Plasminogen Activator (rt-PA) thrombolysis in hyperacute stroke patients with aphasia – A case report. Journal of Emergency Medicine Case Reports. 2025;16(1):34-37. doi:10.33706/jemcr.1592792
Chicago
Md Pauzi, Ahmad Luqman, ve Juliana Hashim. 2025. “Importance of Recombinant Tissue Plasminogen Activator (rt-PA) thrombolysis in hyperacute stroke patients with aphasia – A case report”. Journal of Emergency Medicine Case Reports 16 (1): 34-37. https://doi.org/10.33706/jemcr.1592792.
EndNote
Md Pauzi AL, Hashim J (01 Mart 2025) Importance of Recombinant Tissue Plasminogen Activator (rt-PA) thrombolysis in hyperacute stroke patients with aphasia – A case report. Journal of Emergency Medicine Case Reports 16 1 34–37.
IEEE
[1]A. L. Md Pauzi ve J. Hashim, “Importance of Recombinant Tissue Plasminogen Activator (rt-PA) thrombolysis in hyperacute stroke patients with aphasia – A case report”, Journal of Emergency Medicine Case Reports, c. 16, sy 1, ss. 34–37, Mar. 2025, doi: 10.33706/jemcr.1592792.
ISNAD
Md Pauzi, Ahmad Luqman - Hashim, Juliana. “Importance of Recombinant Tissue Plasminogen Activator (rt-PA) thrombolysis in hyperacute stroke patients with aphasia – A case report”. Journal of Emergency Medicine Case Reports 16/1 (01 Mart 2025): 34-37. https://doi.org/10.33706/jemcr.1592792.
JAMA
1.Md Pauzi AL, Hashim J. Importance of Recombinant Tissue Plasminogen Activator (rt-PA) thrombolysis in hyperacute stroke patients with aphasia – A case report. Journal of Emergency Medicine Case Reports. 2025;16:34–37.
MLA
Md Pauzi, Ahmad Luqman, ve Juliana Hashim. “Importance of Recombinant Tissue Plasminogen Activator (rt-PA) thrombolysis in hyperacute stroke patients with aphasia – A case report”. Journal of Emergency Medicine Case Reports, c. 16, sy 1, Mart 2025, ss. 34-37, doi:10.33706/jemcr.1592792.
Vancouver
1.Ahmad Luqman Md Pauzi, Juliana Hashim. Importance of Recombinant Tissue Plasminogen Activator (rt-PA) thrombolysis in hyperacute stroke patients with aphasia – A case report. Journal of Emergency Medicine Case Reports. 01 Mart 2025;16(1):34-7. doi:10.33706/jemcr.1592792