A rare case report of acute vitamin D toxicity due to suicide attempt

Yıl 2025, Cilt: 16 Sayı: 3, 126 - 128, 30.09.2025

Amir Reza Bahadori , Mitra Rahimi , Babak Mostafazadeh , Peyman Erfan Talab Evini , Shahin Shadnia

https://izlik.org/JA96BE42PM

Öz

Background: Acute vitamin D toxicity is an uncommon event that might happen especially owing to attempted of suicide. Vitamin D toxicity could induce hypercalcemia, Acute kidney injury, and cardiac problems in patients. Case presentation: A 49-year-old Iranian man who has a known case of cerebellar palsy and major depressive disorder refers to us with an issue of calcium – vitamin D tablets overdose due to suicide attempt. He admitted with impression of acute vitamin D toxicity. After treatment with hydration, dialysis, Lasix, calcitonin, Denosumab, and Zoledronic Acid patient clinics improved significantly. Conclusion: Physicians must treat vitamin D overdose patients immediately to prevent secondary adverse effects of hypercalcemia.

Anahtar Kelimeler

Vitamin D toxicity , Suicide attempt , Hypercalcemia , Case report

İntihar girişimine bağlı akut D vitamini toksisitesinin nadir görülen bir vaka raporu

https://izlik.org/JA96BE42PM

Öz

Giriş: Akut D vitamini toksisitesi, özellikle intihar girişimi nedeniyle ortaya çıkabilen nadir bir olaydır. D vitamini toksisitesi hastalarda hiperkalsemi, akut böbrek hasarı ve kalp sorunlarına neden olabilir. Vaka sunumu: Serebellar palsi ve majör depresif bozukluk bilinen bir vakası olan 49 yaşında bir İranlı erkek, intihar girişimi nedeniyle kalsiyum-D vitamini tabletleri aşırı dozuyla bize başvurdu. Akut D vitamini toksisitesi izlenimiyle başvurdu. Hidrasyon, diyaliz, Lasix, kalsitonin, Denosumab ve Zoledronik Asit tedavisinin ardından hasta klinikleri önemli ölçüde iyileşti. Sonuç: Hekimler, hiperkalseminin ikincil yan etkilerini önlemek için D vitamini aşırı doz hastalarını derhal tedavi etmelidir.

Anahtar Kelimeler

D vitamini toksisitesi , İntihar girişimi , Hiperkalsemi , Vaka raporu

Kaynakça

• 1. Sarma A. Vitamin D toxicity presenting with altered sensorium and hypercalcaemia. Indian Journal of Anaesthesia. 2020;64(10):909-11.
• 2. Asif A, Farooq N. Vitamin D toxicity. StatPearls [Internet]: StatPearls Publishing; 2023.
• 3. Muneer S, Siddiqui I, Majid H, Zehra N, Jafri L, Khan AH. Practices of vitamin D supplementation leading to vitamin D toxicity: Experience from a Low-Middle Income Country. Annals of Medicine and Surgery. 2022;73:103227.
• 4. Feghali K, Papamarkakis K, Clark J, Malhotra N, Stoddart L, Osakwe I. Vitamin D toxicity managed with peritoneal dialysis. Case Reports in Endocrinology. 2021;2021.
• 5. Lee JP, Tansey M, Jetton JG, Krasowski MD. Vitamin D toxicity: a 16-year retrospective study at an academic medical center. Laboratory medicine. 2018;49(2):123-9.
• 6. Galior K, Grebe S, Singh R. Development of vitamin D toxicity from overcorrection of vitamin D deficiency: a review of case reports. Nutrients. 2018;10(8):953.
• 7. Bhat JR, Geelani SA, Khan AA, Roshan R, Rathod SG. Vitamin D toxicity due to self-prescription: A case report. Journal of Family Medicine and Primary Care. 2022;11(4):1561-3.
• 8. Motlaghzadeh Y, Bilezikian JP, Sellmeyer DE. Hypercalcemia due to vitamin D toxicity. Feldman and Pike’s Vitamin D. 2024:625-50.
• 9. Batman A, Saygili ES, Yildiz D, Sen EC, Erol RS, Canat MM, et al. Risk of hypercalcemia in patients with very high serum 25‐OH vitamin D levels. International journal of clinical practice. 2021;75(7):e14181.
• 10. Maharlouei N, Kasraei H, Shaygani F, Bahadori AR, Khonyagar S, Reyhani Z, et al. The 8th International Conference on Women’s Health; Women’s Mental Health. Women’s Health Bulletin. 2020;7(1):58-61.
• 11. Miao D, Goltzman D. Mechanisms of action of vitamin D in delaying aging and preventing disease by inhibiting oxidative stress. Vitamins and hormones. 121: Elsevier; 2023. p. 293-318.
• 12. Kazemian E, Pourali A, Sedaghat F, Karimi M, Basirat V, Sajadi Hezaveh Z, et al. Effect of supplemental vitamin D3 on bone mineral density: a systematic review and meta-analysis. Nutrition reviews. 2023;81(5):511-30.
• 13. Mobarak S, Salasi M, Hormati A, Khodadadi J, Ziaee M, Abedi F, et al. Evaluation of the effect of sofosbuvir and daclatasvir in hospitalized COVID-19 patients: a randomized doubleblind clinical trial (DISCOVER). Journal of Antimicrobial Chemotherapy. 2022;77(3):758-66.
• 14. Tabatabaii SA, Taghizadeh-Behbahani A, Khanbabaee G, Alibakhshi M, Bahadori AR, Farahbakhsh N. Patient-Reported Outcomes and Healthcare Practices: A Retrospective Analysis of Cystic Fibrosis Management During the COVID-19 Pandemic. Archives of Pediatric Infectious Diseases. 2024(In Press).
• 15. Rizwan M, Cheng K, Gang Y, Hou Y, Wang C. Immunomodulatory Effects of Vitamin D and Zinc on Viral Infection. Biological Trace Element Research. 2024:1-17.
• 16. Rebelos E, Tentolouris N, Jude E. The role of vitamin D in health and disease: a narrative review on the mechanisms linking vitamin d with disease and the effects of supplementation. Drugs. 2023;83(8):665-85.
• 17. Graidis S, Papavramidis TS, Papaioannou M. Vitamin D and acute kidney injury: A two-way causality relation and a predictive, prognostic, and therapeutic role of vitamin D. Frontiers in nutrition. 2021;7:630951.
• 18. Misgar RA, Sahu D, Bhat MH, Wani AI, Bashir MI. Vitamin D toxicity: a prospective study from a tertiary care centre in Kashmir Valley. Indian journal of endocrinology and metabolism. 2019;23(3):363-6.
• 19. Grill J, Holzapfel E, Klaus R, Pozza S, Lechner H, Lange- Sperandio B. Vitamin D intoxication with hyper-calcemia and acute kidney injury. Journal of Clinical Images and Medical Case Reports. 2022;2(4):1219.
• 20. Bagrul D, Atik F. Association of vitamin D deficiency with ventricular repolarization abnormalities. Polish Heart Journal (Kardiologia Polska). 2019;77(9):853-8.
• 21. Barsan M, Brata AM, Ismaiel A, Dumitrascu DI, Badulescu A-V, Duse TA, et al. The pathogenesis of cardiac arrhythmias in vitamin D deficiency. Biomedicines. 2022;10(6):1239.
• 22. Zhang H, Jiang Y, Shi N, Lu Y-Q. Serum vitamin D levels and acute kidney injury: a systemic review and meta-analysis. Scientific Reports. 2022;12(1):20365.
• 23. Bahadori AR, Mohammadian S, Davari A. Minireview: Vitamin D toxicity: Diagnosis, management, and treatment. J Clin Med Images Case Rep. 2024; 4(3): 1690.
• 24. MM Basso S, Lumachi F, Nascimben F, Luisetto G, Camozzi V. Treatment of acute hypercalcemia. Medicinal Chemistry. 2012;8(4):564-8.