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Critical Illness Polyneuropathy Developing In The Early Period After An Epileptic Seizure: Two Case Reports

Yıl 2026, Cilt: 17 Sayı: 1 , 14 - 16 , 31.03.2026
https://doi.org/10.33706/jemcr.1738131
https://izlik.org/JA86RC97US

Öz

Critical illness polyneuropathy (CIP) is characterized by muscle weakness and atrophy in intensive care patients. Although recovery may occur by addressing the underlying cause, plasmapheresis or immunoglobulin therapy may be necessary in severe cases. We present two female patients (aged 76 and 52) who developed CIP in the early phase following epileptic seizures. CIP was suspected due to difficulty in ventilator weaning, and EMG confirmed the diagnosis. Both patients underwent five sessions of plasmapheresis and were successfully weaned from the ventilator, regaining full (5/5) muscle strength in all extremities. Early diagnosis is crucial in preventing complications and increasing treatment success in CIP.

Kaynakça

  • Kerbaul F, Brousse M, Collart F, et al. Combination of histopathological and electromyographic patterns can help to evaluate functional outcome of critical ill patients with neuromuscular weakness syndromes. Crit Care. 2004;8(6):R358-66. doi:10.1186/cc2925
  • Hermans G, De Jonghe B, Bruyninckx F, et al.. Clinical review: Critical illness polyneuropathy and myopathy. Crit Care. 2008;12(6):238. doi:10.1186/cc7100
  • Mohr M, Englisch L, Roth A, et al. Effects of early treatment with immunoglobulin on critical illness polyneuropathy following multiple organ failure and gram-negative sepsis. Intensive Care Med. 1997;23(11):1144-1149. doi:10.1007/s001340050471
  • Bolton CF. Neuromuscular manifestations of critical illness. Muscle Nerve. 2005;32(2):140-163. doi:10.1002/mus.20304
  • Hantus S. Epilepsy Emergencies. Continuum (Minneap Minn). 2016;22 (1 Epilepsy): 173-190. doi: 10.1212/CON. 0000000000000285
  • van Mook WNKA, Hulsewé-Evers RPMG. Critical illness polyneuropathy. Curr Opin Crit Care. 2002;8(4):302-310. doi:10.1097/00075198-200208000-00006
  • Garnacho-Montero J, Madrazo-Osuna J, García-Garmendia JL, et al. Critical illness polyneuropathy: risk factors and clinical consequences. A cohort study in septic patients. Intensive Care Med. 2001;27(8):1288-1296. doi:10.1007/s001340101009
  • Wijdicks EF, Litchy WJ, Harrison BA, et al. The clinical spectrum of critical illness polyneuropathy. Mayo Clin Proc. 1994;69(10):955-959. doi:10.1016/s0025-6196(12)61819-9
  • Shepherd S, Batra A, Lerner DP. Review of Critical Illness Myopathy and Neuropathy. The Neurohospitalist. 2017;7(1):41-48. doi:10.1177/1941874416663279
  • Johnson KL. Neuromuscular complications in the intensive care unit: critical illness polyneuromyopathy. AACN Adv Crit Care. 2007;18(2):162-167. doi:10.1097/01. AACN.0000269260.99169.70
  • Abdulla E, Janjua T, Agrawal A et al. Neurogenically Originated Inflammatory Response Syndrome: Role in the Neurocritical Patient. J Neurointensive Care. 2022;5(2):39-43. doi:10.32587/jnic.2022.00514
  • Rony RMIK, Shokrani A, Malhi NK, et al. Therapeutic Plasma Exchange: Current and Emerging Applications to Mitigate Cellular Signaling in Disease. Biomolecules. 2025;15(7):1000. Published 2025 Jul 12. doi:10.3390/biom15071000

Epileptik Nöbet Sonrası Erken Dönemde Gelişen Kritik Hastalık Polinöropatisi: İki Olgu Sunumu

Yıl 2026, Cilt: 17 Sayı: 1 , 14 - 16 , 31.03.2026
https://doi.org/10.33706/jemcr.1738131
https://izlik.org/JA86RC97US

Öz

Kritik hastalık polinöropatisi (CIP), yoğun bakım hastalarında kas güçsüzlüğü ve atrofi ile karakterizedir. Altta yatan nedenin tedavisiyle iyileşme mümkün olsa da, ağır vakalarda plazmaferez veya immünoglobulin tedavisi gerekebilir. Bu yazıda epileptik nöbetlerin ardından erken dönemde CIP gelişen iki kadın hasta (76 ve 52 yaşlarında) sunulmaktadır. Her iki olguda da ventilatörden ayırma güçlüğü nedeniyle CIP şüphesi oluşmuş ve EMG ile tanı doğrulanmıştır. Her iki hastaya da beşer seans plazmaferez uygulanmış ve başarıyla ventilatörden ayrılmışlardır. Tüm ekstremitelerde kas gücü tamamen (5/5) geri kazanılmıştır. CIP'te erken tanı, komplikasyonların önlenmesi ve tedavi başarısının artırılması açısından kritik öneme sahiptir.

Kaynakça

  • Kerbaul F, Brousse M, Collart F, et al. Combination of histopathological and electromyographic patterns can help to evaluate functional outcome of critical ill patients with neuromuscular weakness syndromes. Crit Care. 2004;8(6):R358-66. doi:10.1186/cc2925
  • Hermans G, De Jonghe B, Bruyninckx F, et al.. Clinical review: Critical illness polyneuropathy and myopathy. Crit Care. 2008;12(6):238. doi:10.1186/cc7100
  • Mohr M, Englisch L, Roth A, et al. Effects of early treatment with immunoglobulin on critical illness polyneuropathy following multiple organ failure and gram-negative sepsis. Intensive Care Med. 1997;23(11):1144-1149. doi:10.1007/s001340050471
  • Bolton CF. Neuromuscular manifestations of critical illness. Muscle Nerve. 2005;32(2):140-163. doi:10.1002/mus.20304
  • Hantus S. Epilepsy Emergencies. Continuum (Minneap Minn). 2016;22 (1 Epilepsy): 173-190. doi: 10.1212/CON. 0000000000000285
  • van Mook WNKA, Hulsewé-Evers RPMG. Critical illness polyneuropathy. Curr Opin Crit Care. 2002;8(4):302-310. doi:10.1097/00075198-200208000-00006
  • Garnacho-Montero J, Madrazo-Osuna J, García-Garmendia JL, et al. Critical illness polyneuropathy: risk factors and clinical consequences. A cohort study in septic patients. Intensive Care Med. 2001;27(8):1288-1296. doi:10.1007/s001340101009
  • Wijdicks EF, Litchy WJ, Harrison BA, et al. The clinical spectrum of critical illness polyneuropathy. Mayo Clin Proc. 1994;69(10):955-959. doi:10.1016/s0025-6196(12)61819-9
  • Shepherd S, Batra A, Lerner DP. Review of Critical Illness Myopathy and Neuropathy. The Neurohospitalist. 2017;7(1):41-48. doi:10.1177/1941874416663279
  • Johnson KL. Neuromuscular complications in the intensive care unit: critical illness polyneuromyopathy. AACN Adv Crit Care. 2007;18(2):162-167. doi:10.1097/01. AACN.0000269260.99169.70
  • Abdulla E, Janjua T, Agrawal A et al. Neurogenically Originated Inflammatory Response Syndrome: Role in the Neurocritical Patient. J Neurointensive Care. 2022;5(2):39-43. doi:10.32587/jnic.2022.00514
  • Rony RMIK, Shokrani A, Malhi NK, et al. Therapeutic Plasma Exchange: Current and Emerging Applications to Mitigate Cellular Signaling in Disease. Biomolecules. 2025;15(7):1000. Published 2025 Jul 12. doi:10.3390/biom15071000
Toplam 12 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Acil Tıp, Yoğun Bakım
Bölüm Olgu Sunumu
Yazarlar

Şeyma Ataman 0000-0002-9846-3745

Hasan Hüseyin Kozak 0000-0001-6904-8545

Leyla Köse Leba 0000-0002-5989-6548

Sami Ataman 0000-0002-2197-4715

Gönderilme Tarihi 18 Temmuz 2025
Kabul Tarihi 12 Aralık 2025
Yayımlanma Tarihi 31 Mart 2026
DOI https://doi.org/10.33706/jemcr.1738131
IZ https://izlik.org/JA86RC97US
Yayımlandığı Sayı Yıl 2026 Cilt: 17 Sayı: 1

Kaynak Göster

APA Ataman, Ş., Kozak, H. H., Köse Leba, L., & Ataman, S. (2026). Critical Illness Polyneuropathy Developing In The Early Period After An Epileptic Seizure: Two Case Reports. Journal of Emergency Medicine Case Reports, 17(1), 14-16. https://doi.org/10.33706/jemcr.1738131
AMA 1.Ataman Ş, Kozak HH, Köse Leba L, Ataman S. Critical Illness Polyneuropathy Developing In The Early Period After An Epileptic Seizure: Two Case Reports. Journal of Emergency Medicine Case Reports. 2026;17(1):14-16. doi:10.33706/jemcr.1738131
Chicago Ataman, Şeyma, Hasan Hüseyin Kozak, Leyla Köse Leba, ve Sami Ataman. 2026. “Critical Illness Polyneuropathy Developing In The Early Period After An Epileptic Seizure: Two Case Reports”. Journal of Emergency Medicine Case Reports 17 (1): 14-16. https://doi.org/10.33706/jemcr.1738131.
EndNote Ataman Ş, Kozak HH, Köse Leba L, Ataman S (01 Mart 2026) Critical Illness Polyneuropathy Developing In The Early Period After An Epileptic Seizure: Two Case Reports. Journal of Emergency Medicine Case Reports 17 1 14–16.
IEEE [1]Ş. Ataman, H. H. Kozak, L. Köse Leba, ve S. Ataman, “Critical Illness Polyneuropathy Developing In The Early Period After An Epileptic Seizure: Two Case Reports”, Journal of Emergency Medicine Case Reports, c. 17, sy 1, ss. 14–16, Mar. 2026, doi: 10.33706/jemcr.1738131.
ISNAD Ataman, Şeyma - Kozak, Hasan Hüseyin - Köse Leba, Leyla - Ataman, Sami. “Critical Illness Polyneuropathy Developing In The Early Period After An Epileptic Seizure: Two Case Reports”. Journal of Emergency Medicine Case Reports 17/1 (01 Mart 2026): 14-16. https://doi.org/10.33706/jemcr.1738131.
JAMA 1.Ataman Ş, Kozak HH, Köse Leba L, Ataman S. Critical Illness Polyneuropathy Developing In The Early Period After An Epileptic Seizure: Two Case Reports. Journal of Emergency Medicine Case Reports. 2026;17:14–16.
MLA Ataman, Şeyma, vd. “Critical Illness Polyneuropathy Developing In The Early Period After An Epileptic Seizure: Two Case Reports”. Journal of Emergency Medicine Case Reports, c. 17, sy 1, Mart 2026, ss. 14-16, doi:10.33706/jemcr.1738131.
Vancouver 1.Şeyma Ataman, Hasan Hüseyin Kozak, Leyla Köse Leba, Sami Ataman. Critical Illness Polyneuropathy Developing In The Early Period After An Epileptic Seizure: Two Case Reports. Journal of Emergency Medicine Case Reports. 01 Mart 2026;17(1):14-6. doi:10.33706/jemcr.1738131