Could Propafenone hydrochloride Cause Visual Hallucination?

Öz

Introduction: There may be some cardiac and non-cardiac side effects of propafenone hydrochloride, which is a class IC antiarrhythmic agent used for medical cardioversion in atrial fibrillation and atrial flutter. Case Report: Propafenone hydrochloride (600 mg) was orally administered to a 74-year-old patient with tachycardia due to new-onset atrial fibrillation with rapid ventricular response. After 30 min, sinus bradycardia in response to atropine, swelling and numbness in the tongue, slurred speech, blurred vision, diplopia, spasm and contradiction at the right arm and leg, drowsiness, and visual hallucinations lasting for 24 h developed. The patient recovered without any sequel and was discharged from the coronary intensive care unit. Conclusion: Although propafenone hydrochloride is known to be safe at therapeutic doses, various possible multiple side effects should be considered

Anahtar Kelimeler

• Propafenone HCl, side effect, hallucinations, emergency service

Kaynakça

1. Kawase A, Ikeda T, Nakazawa K, Ashihara T, Namba T, Kubota T, et al. Widening of the excitable gap and enlargement of the core of reentry during atrial fibrillation with a pure sodium channel blocker in canine atria. Circulation 2003; 107: 905-10. [CrossRef]
2. Donald M. Yealy and Theodore R. Dysrhythmias. In Marx JA, Hockberger RS, Walls RM, Adams J, eds. Delbridge.Rosen's emergency medicine, concepts and clinical practice. 7th ed. Philadelphia:PA 19103-2899. 2010: 984-1024.
3. Brubacher J, Bicarbonate therapy for unstable propafenone-induced wide complex tachycardia. Pharmacotherapy CJEM 2004; 6: 349-56.
4. http://www.medicinenet.com/propafenone-oral/page2.htm. Available 11.08.2015.
5. Gillis AM, Verma A, Talajic M, Nattel S, Dorian P; CCS Atrial Fibrillation Guidelines Committee. Canadian Cardiovascular Society atrial fibrillation guidelines 2010: rate and rhythm management. Can J of Cardiol 2011; 27: 47-59. [CrossRef]
6. Koppel C, Oberdisse U, Heinemeyer G, Clinical course and out- come in class IC antiarrhythmic overdose. J Toxicol Clin Toxi- col 1990; 28: 433-44. [CrossRef]
7. Wagner F, Kalusche D, Trenk D, Jahnchen E, Roskamm H, Drug interaction between propafenone and metoprolol. Br J Clin Pharmacol 1987; 24: 213-220. [CrossRef]
8. Torres D, Parrinello G, Paterna S, Bellanca M, Licata G, Severe, Brochostenosis by Oral Propafenone Immediately After Commencing Treatment. Am J Ther 2011 Jan 18. [CrossRef]

9. Pfeffer F, Grube M, An organic psychosis due to a venlafaxine-propafenone interaction. Int J Psychiatry Med 2001; 31: 427-32. [CrossRef]
10. Bayram B, Dedeoğlu E, Hocaoğlu N, Gazi E, Propafenone-induced cardiac arrest: full recovery with insulin, is it possible? Am J Emerg Med 2013; 31: 457. [CrossRef] JEMCR 2016; 1; 17-9