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A Rare Case of Paraneoplastic Limbic Encephalitis leading to Epileptic Seizure in a Patient with Ovarian Carcinoma

Yıl 2022, , 16 - 18, 08.03.2022
https://doi.org/10.33706/jemcr.991046

Öz

Introduction
Paraneoplastic limbic encephalitis (PLE), a rare and diagnostically-challenging encephalopathy, is frequently associated with an underlying malign neoplastic tumor. Epileptic symptoms are uncommon but can be the first sign of the disease.
Case Report
We present a patient admitted to our intensive care unit (ICU) unit with epileptic seizure and a Glasgow Coma Scale (GCS) of six. All tests and investigations that had been utilized for this patient’s diagnosis, including blood tests, serological analyses, magnetic resonance imaging (MRI), electroencephalogram (EEG) and cerebrospinal fluid (CSF) test results were evaluated. The patient had been diagnosed with ovarian carcinoma within the last year. The patient’s cancer history, her most recent complaints and MRI results were strongly suspicious for paraneoplastic limbic encephalitis. Her neurological condition improved rapidly in a few days with steroid therapy.
Conclusion
This case showed that any neurological deterioration based on an ovarian oncologic disease can bring PLE to mind. The possibility of PLE must be taken into consideration in patients presenting with epileptic seizures after neoplastic diagnoses.

Destekleyen Kurum

None

Kaynakça

  • 1. Corsellis JA, Goldberg GJ, Norton AR. “Limbic encephalitis” and its association with carcinoma. Brain 1968; 91: 481-96.
  • 2. Markakis I, Papathanasiou A, Papageorgiou E, Siarkos K, Gkekas G. Paraneoplastic Limbic Encephalitis Resembling Acute Herpetic Encephalitis. Case Rep Neurol Med 2013; 2013: 608643.
  • 3. Chandra SR, Seshadri R, Chikabasaviah Y, Isaac TG. Progressive limbic encephalopathy: Problems and prospects. Ann Indian Acad Neurol 2014 Apr; 17(2): 166-70.
  • 4. Grisold W, Giometto B, Vitaliani R, Oberndorfer S. Current approaches to the treatment of paraneoplastic encephalitis. Ther Adv Neurol Disord 2011; 4: 237-48.
  • 5. Jagtap SA, Das GK, Kambale HJ, Radhakrishnan A, Nair MD. Limbic encephalitis: Clinical spectrum and long-term outcome from a developing country perspective. Ann Indian Acad Neurol 2014; 17: 161-5.
  • 6. Kaira K, Okamura T, Takahashi H, Horiguchi N, Sunaga N, Hisada T, et al. Small-cell lung cancer with voltage-gated calcium channel antibody-positive paraneoplastic limbic encephalitis: a case report. J Med Case Rep 2014; 8: 119.
  • 7. Toyota T, Akamatsu N, Tsuji S, Nishizawa S. Limbic Encephalitis Associated with Anti-Voltage-Gated Potassium Channel Complex Antibodies as a Cause of Adult-Onset Mesial Temporal Lobe Epilepsy. J UOEH 2014; 36: 129-33.
  • 8. Van Vliet J, Mulleners W, Meulstee J. EEG leading to the diagnosis of limbic encephalitis. Clin EEG Neurosci 2012; 43: 161-4.
Yıl 2022, , 16 - 18, 08.03.2022
https://doi.org/10.33706/jemcr.991046

Öz

Kaynakça

  • 1. Corsellis JA, Goldberg GJ, Norton AR. “Limbic encephalitis” and its association with carcinoma. Brain 1968; 91: 481-96.
  • 2. Markakis I, Papathanasiou A, Papageorgiou E, Siarkos K, Gkekas G. Paraneoplastic Limbic Encephalitis Resembling Acute Herpetic Encephalitis. Case Rep Neurol Med 2013; 2013: 608643.
  • 3. Chandra SR, Seshadri R, Chikabasaviah Y, Isaac TG. Progressive limbic encephalopathy: Problems and prospects. Ann Indian Acad Neurol 2014 Apr; 17(2): 166-70.
  • 4. Grisold W, Giometto B, Vitaliani R, Oberndorfer S. Current approaches to the treatment of paraneoplastic encephalitis. Ther Adv Neurol Disord 2011; 4: 237-48.
  • 5. Jagtap SA, Das GK, Kambale HJ, Radhakrishnan A, Nair MD. Limbic encephalitis: Clinical spectrum and long-term outcome from a developing country perspective. Ann Indian Acad Neurol 2014; 17: 161-5.
  • 6. Kaira K, Okamura T, Takahashi H, Horiguchi N, Sunaga N, Hisada T, et al. Small-cell lung cancer with voltage-gated calcium channel antibody-positive paraneoplastic limbic encephalitis: a case report. J Med Case Rep 2014; 8: 119.
  • 7. Toyota T, Akamatsu N, Tsuji S, Nishizawa S. Limbic Encephalitis Associated with Anti-Voltage-Gated Potassium Channel Complex Antibodies as a Cause of Adult-Onset Mesial Temporal Lobe Epilepsy. J UOEH 2014; 36: 129-33.
  • 8. Van Vliet J, Mulleners W, Meulstee J. EEG leading to the diagnosis of limbic encephalitis. Clin EEG Neurosci 2012; 43: 161-4.
Toplam 8 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Klinik Tıp Bilimleri
Bölüm Case Report
Yazarlar

Murat Hamit Aytar 0000-0002-4323-542X

Levent Kılıçkan Bu kişi benim 0000-0002-8931-3673

Cemal Ustun 0000-0003-3510-9703

Elvan Cevizci Akkılıç 0000-0002-9928-997X

Yayımlanma Tarihi 8 Mart 2022
Gönderilme Tarihi 8 Eylül 2021
Yayımlandığı Sayı Yıl 2022

Kaynak Göster

APA Aytar, M. H., Kılıçkan, L., Ustun, C., Cevizci Akkılıç, E. (2022). A Rare Case of Paraneoplastic Limbic Encephalitis leading to Epileptic Seizure in a Patient with Ovarian Carcinoma. Journal of Emergency Medicine Case Reports, 13(1), 16-18. https://doi.org/10.33706/jemcr.991046
AMA Aytar MH, Kılıçkan L, Ustun C, Cevizci Akkılıç E. A Rare Case of Paraneoplastic Limbic Encephalitis leading to Epileptic Seizure in a Patient with Ovarian Carcinoma. Journal of Emergency Medicine Case Reports. Mart 2022;13(1):16-18. doi:10.33706/jemcr.991046
Chicago Aytar, Murat Hamit, Levent Kılıçkan, Cemal Ustun, ve Elvan Cevizci Akkılıç. “A Rare Case of Paraneoplastic Limbic Encephalitis Leading to Epileptic Seizure in a Patient With Ovarian Carcinoma”. Journal of Emergency Medicine Case Reports 13, sy. 1 (Mart 2022): 16-18. https://doi.org/10.33706/jemcr.991046.
EndNote Aytar MH, Kılıçkan L, Ustun C, Cevizci Akkılıç E (01 Mart 2022) A Rare Case of Paraneoplastic Limbic Encephalitis leading to Epileptic Seizure in a Patient with Ovarian Carcinoma. Journal of Emergency Medicine Case Reports 13 1 16–18.
IEEE M. H. Aytar, L. Kılıçkan, C. Ustun, ve E. Cevizci Akkılıç, “A Rare Case of Paraneoplastic Limbic Encephalitis leading to Epileptic Seizure in a Patient with Ovarian Carcinoma”, Journal of Emergency Medicine Case Reports, c. 13, sy. 1, ss. 16–18, 2022, doi: 10.33706/jemcr.991046.
ISNAD Aytar, Murat Hamit vd. “A Rare Case of Paraneoplastic Limbic Encephalitis Leading to Epileptic Seizure in a Patient With Ovarian Carcinoma”. Journal of Emergency Medicine Case Reports 13/1 (Mart 2022), 16-18. https://doi.org/10.33706/jemcr.991046.
JAMA Aytar MH, Kılıçkan L, Ustun C, Cevizci Akkılıç E. A Rare Case of Paraneoplastic Limbic Encephalitis leading to Epileptic Seizure in a Patient with Ovarian Carcinoma. Journal of Emergency Medicine Case Reports. 2022;13:16–18.
MLA Aytar, Murat Hamit vd. “A Rare Case of Paraneoplastic Limbic Encephalitis Leading to Epileptic Seizure in a Patient With Ovarian Carcinoma”. Journal of Emergency Medicine Case Reports, c. 13, sy. 1, 2022, ss. 16-18, doi:10.33706/jemcr.991046.
Vancouver Aytar MH, Kılıçkan L, Ustun C, Cevizci Akkılıç E. A Rare Case of Paraneoplastic Limbic Encephalitis leading to Epileptic Seizure in a Patient with Ovarian Carcinoma. Journal of Emergency Medicine Case Reports. 2022;13(1):16-8.