Giriş: Sildenafil sitrat (SS) günümüzde erektil disfonksiyon
ve pulmoner arteriyel hipertansiyon tedavisinde kullanılan
bir ilaçtır. İlacın aşırı alımı ile ilgili en sık bildirilen yan etkiler;
ciltte kızarıklık, baş dönmesi, baş ağrısı, taşikardi, vertigo ve
göğüs ağrısıdır. İlacın kullanımına bağlı oftalmik yan etkilerin
görülebileceği belirtilmekle beraber, literatürde SS aşırı alımına
bağlı mavi renkte görmenin bildirildiği bir olgu yoktur.
Olgu Sunumu: SS’nin intihar amaçlı aşırı alımına bağlı olarak
gelişen ve yaklaşık 4 saat süresince mavi renkte görme ve sinus
taşikardisi kliniğiyle takip edilen ve bu durumların spontan
gerilediği 27 yaşında bir erkek hastayı sunuyoruz. Bu klinik
durum, herhangi bir müdahale gerektirmeksizin spontan
sonlandı. Hasta intihar amacıyla yaklaşık 1500 mg SS içmişti.
Görme algısındaki bu durumun düzelmesinden sonra yaklaşık
6 saat daha acil servis gözlem ünitesinde takip edilen hasta
herhangi bir komplikasyon veya sekel olmaksızın taburcu edildi.
Sonuç: Sonuç olarak SS aşırı alımında hastalarda oftalmik sistem
ve görme ile ilgili yan etkiler görülebilir. Altta yatan santral veya
vasküler bir neden yoksa bu görme rengi değişiklikleri spontan
gerileyebilir
Sildenafil: Drug information. Available: March 15, 2015. Avail- able at: http://www.uptodate.com/contents/sildenafil-drug- information?source=search_result&search=sildenafil&selectedTit le=1~150.
Wills BK, Albinson C, Wahl M, Clifton J. Sildenafil citrate ingestion and prolonged priapism and tachycardia in a pediatric patient. Clin Toxicol (Phila) 2007; 45: 798-800. [CrossRef]
Tracqui A, Miras A, Tabib A, Raul JS, Ludes B, Malicier D. Fatal overdosage with sildenafil citrate (Viagra): first report and review of the literature. Hum Exp Toxicol 2002; 21: 623-9. [CrossRef]
Hung DZ, Yang DY. Sildenafil overdose in a female patient. J Toxicol Clin Toxicol 2001; 39: 423-4. [CrossRef]
Oh DJ. Sildenafil overdose can cause rhabdomyolysis and subjective vi- sual perception changes. Nephrology (Carlton) 2014; 19: 258. [CrossRef]
Akash R, Hrishikesh D, Amith P, Sabah S. Case report: association of combined nonarteritic anterior ischemic optic neuropathy (NAION) and obstruction of cilioretinal artery with overdose of Viagra. J Ocul Pharmacol Ther 2005; 21: 315-7. [CrossRef]
Naranjo CA, Busto U, Sellers EM, Sandor P, Ruiz I, Roberts EA, et al. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther 1981; 30: 239-45. [CrossRef]
Blue Vision and Sinus Tachycardia: Sildenafil Citrate Overdose
Introduction: Sildenafil citrate (SC) is used as a drug for the treatment of erectile dysfunction and pulmonary arterial hypertension. The most common side effects associated with overdose of this drug are skin rash, dizziness, headache, tachycardia, vertigo, and chest pain. Although it is noted that ophthalmic side effects might be associated with the use of the drug, there is no reported case of blue vision because of overdose of SC. Case Report: We present the case of a 27-year-old male patient who had sinus tachycardia and blue vision, which developed because of overdose of SC taken in an attempt to commit suicide and which was followed by this clinical state for approximately for 4 h. This clinical status was spontaneously terminated without requiring any intervention. The patient ingested approximately 1500 mg of SC. After improvement in visual perception, the patient was followed-up after approximately 6 h in the observation unit of the emergency department and was discharged without any complication or sequelae.Conclusion: As a result, side effects related to the ophthalmic system and vision may be encountered in patients with an overdose of SC. Unless there are underlying central or vascular conditions that do not cause color change in vision, it may spontaneously resolve
Sildenafil: Drug information. Available: March 15, 2015. Avail- able at: http://www.uptodate.com/contents/sildenafil-drug- information?source=search_result&search=sildenafil&selectedTit le=1~150.
Wills BK, Albinson C, Wahl M, Clifton J. Sildenafil citrate ingestion and prolonged priapism and tachycardia in a pediatric patient. Clin Toxicol (Phila) 2007; 45: 798-800. [CrossRef]
Tracqui A, Miras A, Tabib A, Raul JS, Ludes B, Malicier D. Fatal overdosage with sildenafil citrate (Viagra): first report and review of the literature. Hum Exp Toxicol 2002; 21: 623-9. [CrossRef]
Hung DZ, Yang DY. Sildenafil overdose in a female patient. J Toxicol Clin Toxicol 2001; 39: 423-4. [CrossRef]
Oh DJ. Sildenafil overdose can cause rhabdomyolysis and subjective vi- sual perception changes. Nephrology (Carlton) 2014; 19: 258. [CrossRef]
Akash R, Hrishikesh D, Amith P, Sabah S. Case report: association of combined nonarteritic anterior ischemic optic neuropathy (NAION) and obstruction of cilioretinal artery with overdose of Viagra. J Ocul Pharmacol Ther 2005; 21: 315-7. [CrossRef]
Naranjo CA, Busto U, Sellers EM, Sandor P, Ruiz I, Roberts EA, et al. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther 1981; 30: 239-45. [CrossRef]
Güler, S., Gökçek, İ., Güven, İ., Aytar, H., vd. (2015). Blue Vision and Sinus Tachycardia: Sildenafil Citrate Overdose. Journal of Emergency Medicine Case Reports, 6(4), 87-89.
AMA
Güler S, Gökçek İ, Güven İ, Aytar H, Ramadan H. Blue Vision and Sinus Tachycardia: Sildenafil Citrate Overdose. Journal of Emergency Medicine Case Reports. Ekim 2015;6(4):87-89.
Chicago
Güler, Sertaç, İrfan Gökçek, İbrahim Güven, Halit Aytar, ve Hayri Ramadan. “Blue Vision and Sinus Tachycardia: Sildenafil Citrate Overdose”. Journal of Emergency Medicine Case Reports 6, sy. 4 (Ekim 2015): 87-89.
EndNote
Güler S, Gökçek İ, Güven İ, Aytar H, Ramadan H (01 Ekim 2015) Blue Vision and Sinus Tachycardia: Sildenafil Citrate Overdose. Journal of Emergency Medicine Case Reports 6 4 87–89.
IEEE
S. Güler, İ. Gökçek, İ. Güven, H. Aytar, ve H. Ramadan, “Blue Vision and Sinus Tachycardia: Sildenafil Citrate Overdose”, Journal of Emergency Medicine Case Reports, c. 6, sy. 4, ss. 87–89, 2015.
ISNAD
Güler, Sertaç vd. “Blue Vision and Sinus Tachycardia: Sildenafil Citrate Overdose”. Journal of Emergency Medicine Case Reports 6/4 (Ekim 2015), 87-89.
JAMA
Güler S, Gökçek İ, Güven İ, Aytar H, Ramadan H. Blue Vision and Sinus Tachycardia: Sildenafil Citrate Overdose. Journal of Emergency Medicine Case Reports. 2015;6:87–89.
MLA
Güler, Sertaç vd. “Blue Vision and Sinus Tachycardia: Sildenafil Citrate Overdose”. Journal of Emergency Medicine Case Reports, c. 6, sy. 4, 2015, ss. 87-89.
Vancouver
Güler S, Gökçek İ, Güven İ, Aytar H, Ramadan H. Blue Vision and Sinus Tachycardia: Sildenafil Citrate Overdose. Journal of Emergency Medicine Case Reports. 2015;6(4):87-9.