Thyrotoxic Hypokalemic Periodic Paralysis: Case Report

Yıl 2022, Cilt: 13 Sayı: 1, 22 - 24, 08.03.2022

Seydahmet Akın , Nazire Aladağ , Özcan Keskin , Alara Altintas

https://doi.org/10.33706/jemcr.992103

Öz

Introduction:
Thyrotoxic Hypokalemic Periodic Paralysis (THPP) is a rare hereditary disorder which is characterized by thyroid hormone elevation, low blood potassium level and recurrent acute muscle weakness. Basic pathology is thought to be the increase in activity in the sodium-potassium pump (Na+/K+ATPase).

Case report:
Here we report the case of a 31-year-old male that presented with weakness in his legs, and inability to walk. The patient had elevated thyroid hormone levels (FT3 and FT4) and lower TSH levels, lower serum potassium levels, and recurrent acute muscle weakness. The diagnosis was made to be Thyrotoxic Hypokalemic Periodic Paralysis precipitated after intense physical activity.

Conclusion:
THPP is a reversible medical emergency. Early diagnosis, and rapid treatment is lifesaving. Although rare, THPP must be considered as a differential diagnosis in patients presenting with hypokalemia and paralysis.

Anahtar Kelimeler

endocrine, thyrotoxic hypokalemic periodic paralysis, sodiumpotassiumpump, hypokalemia

Kaynakça

• Kelley DE, Gharib H, Kennedy FP, Duda RJ Jr, McManis PG. Thyrotoxic Periodic Paralysis: report of 10 cases and review of electromyographic findings. ArchInternMed. 1989;149:2597-2600.
• Chan A, Shinde R, Chow CC, Cockram CS, Swaminathan R: Invivoand in vitrosodiumpumpactivity in subjectswiththyrotoxicperiodicparalysis. BMJ 1991;303:1096-1099
• Levey GS, Klein I. Catecholamine-thyroidhormoneinteractionsandthecardiovascularmanifestations of hyperthyroidism. AmJ Med. 1990;88:642-646.
• Kung AWC: Clinicalreview: Thyrotoxicperiodicparalysis: A diagnosticchallenge. J ClinEndocrinolMetab 2006;91:2490-2495 .
• Khan FA, Baron DN 1987 IonfluxandNa , K -ATPaseactivity of erythrocytesandleucocytes in thyroiddisease. ClinSci72:171–179
• Lin SH, Lin YF, Chen DT, Chu P, Hsu CW &Halperin ML. Laboratoryteststodeterminethecause of hypokalemiaand paralysis. Archives of InternalMedicine 2004 164 1561–1566. (doi:10.1001/archinte.164.14.1561)
• Lin SH. Thyrotoxicperiodicparalysis. Mayo ClinicProceedings 2005 80 99–105.
• Ober KP. Thyrotoxicperiodicparalysis in the United States: report of 7 casesandreview of theliterature. Medicine 1992 71 109–120. (doi:10.1097/00005792-199205000-00001)
• NorrisJr FH, Clark EC, Biglieri EG 1972 Studies in thyrotoxicperiodicparalysis. Metabolicandultrastructuralstudies. ArchNeurolSci13:431–432
• Lu KC, Hsu YJ, Chiu JS, Hsu YD, Lin SH 2004 E􀁷ects of potassiumsupplementation on therecovery of thyrotoxicperiodicparalysis. Am J EmergMed22:54454–54457