Bioactive Hydrofiber Dressings with Quince (Cydonia oblonga) Seed Mucilage for Cutaneous Tissue Repair

Öz

Since the skin is the outermost organ with the largest surface area, any disruption to this tissue can significantly affect human life. Such injuries often lead to hospitalization, pain, trauma, risk of scarring, and infections, and therefore require immediate treatment. Hydrofiber systems and wound dressings are extensively investigated and represent innovative fields that support skin regeneration, prevent infections, and promote rapid recovery with reduced pain. Biologically active ingredients play a crucial role in modulating biological and cellular pathways and are widely applied in wound healing and skin regeneration strategies. Natural polymers, due to their biological origin, inherent bioactivity, and their ability to mimic naturally occurring growth factors, are considered promising candidates for wound healing applications. Nature serves as a rich source of biopolymers, and plant extracts have been used since time immemorial for therapeutic purposes. Cydonia oblonga, commonly known as quince, is recognized for its diverse bioactivities that support wound healing and the treatment of skin ailments. In this study, a commercially available hydrofiber dressing enriched with quince seed mucilage (QSM) was evaluated. The QSM enrichment demonstrated improved cellular viability in Human Keratinocyte Cell Lines (HaCaT) when compared to control and hydrofibers.

Anahtar Kelimeler

• Wound Healing
• Natural Polymers
• Hyrofiber
• Quince Seed Mucilage

Kutanöz Doku Onarımı için Cydonia oblonga Tohum Müsilajı İçeren Biyoaktif Hidrofiber Sargılar

Öz

Cilt, vücudumuzun en dışında bulunan ve en geniş yüzey alanına sahip organ olduğu için, bu dokuda meydana gelen herhangi bir bozulma veya hasar insan yaşamını önemli ölçüde etkileyebilmektedir. Bu tür yaralanmalar genellikle hastaneye yatış, ağrı, travma, yara izi riski ve enfeksiyonlarla sonuçlanabilmekte ve bu nedenle acil tedavi gerektirmektedir. Hidrofiber sistemler ve yara örtüleri, cilt yenilenmesini destekleyen, enfeksiyonları önleyen ve daha az ağrıyla hızlı iyileşmeyi teşvik eden yenilikçi yaklaşımlar olarak kapsamlı şekilde araştırılmaktadır. Biyolojik olarak aktif bileşenler, biyolojik ve hücresel yolları düzenlemede önemli rol oynamakta ve yara iyileşmesi ile cilt yenilenmesi stratejilerinde yaygın olarak kullanılmaktadır. Doğal polimerler, biyolojik kökenleri, doğal biyoaktif özellikleri ve büyüme faktörlerini taklit etme yetenekleri nedeniyle yara iyileştirme uygulamaları için umut verici adaylar olarak değerlendirilmektedir. Doğa, biyopolimerler açısından zengin bir kaynak olup, bitki özleri tarih boyunca tedavi amaçlı kullanılmıştır. Ayva olarak bilinen Cydonia oblonga, yara iyileşmesini ve cilt hastalıklarının tedavisini destekleyen çeşitli biyolojik aktiviteleri ile tanınmaktadır. Bu çalışmada, ticari olarak temin edilen bir hidrofiber yara örtüsünün, ayva çekirdeği müsilajı (QSM) ile zenginleştirilmiş halinin biyolojik aktivitesi incelenmiştir. QSM ile zenginleştirilen örneklerin, kontrol ve yalnızca hidrofiber ile karşılaştırıldığında İnsan Keratinosit Hücre Hatlarında (HaCaT) hücre canlılığı ve çoğalmasını artırdığı gösterilmiştir.

Anahtar Kelimeler

• Yara İyileştirici
• Doğal Polimerler
• Hidrofiber
• Ayva Çekirdeği Müsilajı.

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