Investigation of pulmonary function and functional capacity in children with cystic fibrosis in acute pulmonary exacerbation period

Yıl 2024, Cilt: 11 Sayı: 3, 151 - 157, 19.12.2024

Kübra Kılıç , Naciye Vardar Yaglı , Dilber Ademhan Tural , Beste Özsezen , Ebru Yalçın , Melda Sağlam , Ebru Çalık Kütükcü , Deniz İnce , Nagehan Emiralioğlu , Deniz Doğru , Uğur Özçelik , Nural Kiper

https://doi.org/10.15437/jetr.1483134

Öz

Purpose: Patients with cystic fibrosis (CF) may have symptoms such as increased cough and sputum production, decreased
pulmonary function in acute pulmonary exacerbation period. The purpose of this study was to assess pulmonary functions and
functional capacity in children with CF during acute pulmonary exacerbation period.
Methods: Eighteen children with CF who had pulmonary exacerbation (age=12.94±2.57 years, 8 females (44.4%), 10 males
(55.6%)) were reviewed. Patients’ physical and clinical characteristics were recorded. Pulmonary functions were assessed by
using spirometry. Functional capacity was evaluated by 1-minute sit to stand test (STST).
Results: The mean forced expiratory volume in 1 second (FEV1) (%) was 58.50%, forced vital capacity (FVC) (%) was 65.22%, peak
expiratory flow (PEF) (%) was 62.50% and forced mid-expiratory flow (FEF25-75%) (%) was 39.77% in children with CF. According to
the disease severity classification, 77.7% had mild obstructive lung disease. Children with CF were performed 24.88 times sit to
stand repetitions during the test. They reached 41.87% of their predicted STST repetition. No significant correlation was found
between the STST repetition and FEV1 (%) (r=-0.041; p=0.87), FVC (%) (r=-0.085; p=0.73), PEF (%) (r=-0.216; p=0.38) and FEF25-
75% (%) (r=-0.215; p=0.39) in children with CF.
Conclusion: All children with CF in acute pulmonary exacerbation period had decreased functional capacity. In addition, mild
obstructive lung disease was found in the majority of children. The effects of physiotherapy and rehabilitation programs during
the acute pulmonary exacerbation period on lung function and functional capacity should be investigated.

Anahtar Kelimeler

Cystic fibrosis, Exercise test, Pulmonary function test, Exercise capacity

Akut pulmoner alevlenme döneminde olan kistik fibrozisli çocuklarda solunum fonksiyonlarının ve fonksiyonel kapasitenin incelenmesi

Öz

Amaç: Kistik fibrozis (KF)’li hastalarda akut pulmoner alevlenme döneminde öksürük ve balgam miktarında artış, solunum
fonksiyonlarında azalma görülebilmektedir. Bu çalışmanın amacı, akut pulmoner alevlenme döneminde olan KF’li çocuklarda
solunum fonksiyonlarının ve fonksiyonel kapasitenin incelenmesi idi.
Yöntem: Akut pulmoner alevlenme döneminde olan 18 KF’li çocuk hasta (yaş=12,94±2,57 yıl, 8 kız (%44,4), 10 erkek (%55,6))
çalışmaya alındı. Olguların fiziksel ve klinik özellikleri kaydedildi. Solunum fonksiyonları spirometre ile fonksiyonel kapasite ise
1-dakika otur kalk testi (OKT) ile değerlendirildi.
Bulgular: KF’li çocukların ortalama birinci saniyedeki zorlu ekspiratuar volüm (FEV1) (%) değeri %58,50, zorlu vital kapasite (FVC)
(%) değeri %65,22, tepe ekspiratuar akım hızı (PEF) (%) değeri %62,50 ve zorlu ekspirasyonun ortasındaki akım hızı (FEF%25-75)
(%) değeri %39,77 olarak bulundu. Çocukların hastalık şiddeti sınıflandırmasına göre %77,7’si hafif obstrüktif akciğer
hastalığına sahipti. KF’li çocuklar hastaneye yatış sırasında yapılan 1-dakika OKT’de ortalama 24,88 kez oturup kalktılar ve
beklenilen 1-dk OKT sayısının ortalama %41,87’sine ulaştılar. KF’li çocukların 1- dakika OKT sayısı ile FEV1 (%) (r=-0,041;
p=0,87), FVC (%) (r=-0,085; p=0,73), PEF (%) (r=-0,216; p=0,38) ve (FEF%25-75) (%) (r=-0,215; p=0,39) değeri arasında anlamlı
bir ilişki bulunmadı.
Sonuç: Bu çalışmanın sonucunda akut pulmoner alevlenme döneminde olan KF’li çocukların fonksiyonel kapasitelerinin azaldığı
belirlendi. Ayrıca çocukların büyük çoğunluğunda hafif şiddette obstrüktif akciğer hastalığının görüldüğü saptandı. Akut pulmoner
alevlenme döneminde uygulanacak fizyoterapi ve rehabilitasyon programlarının solunum fonksiyonları ve fonksiyonel kapasiteye
etkisi araştırılmalıdır.

Anahtar Kelimeler

Kistik fibrozis, Egzersiz testi, Solunum fonksiyon testi, Egzersiz kapasitesi

Teşekkür

Yazarlar, katılımcı bireylere ve ebeveynlerine teşekkür eder.

Kaynakça

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