ANTİVİRAL ETKİLİ BİTKİLER

Yıl 2022, , 505 - 522, 29.05.2022

Tuğçe İnce Köse , Ayşe Mine Gençler Özkan

https://doi.org/10.33483/jfpau.1057473

Öz

Amaç: Virüsler, her türlü canlı organizmayı enfekte edebilen ajanlardır ve en önemli konaklar insanlar, hayvanlar, bitkiler, bakteriler ve mantarlardır. Viral hastalıklar dünya çapında ciddi morbidite ve mortaliteden sorumludur, halk sağlığı için büyük bir tehdittir ve tüm dünyada önemli bir sorun olmaya devam etmektedir. Bu grup içinde son zamanlarda öne çıkan Coronavirüsler (CoV'ler) Coronaviridae ailesine, Coronavirinae alt ailesine aittir ve hem hayvanları hem de insanları enfekte edebilen büyük (genom boyutu 26−32 kb), zarflı, tek sarmallı ribonükleik asit (RNA) virüsleridir. Dünya son yirmi yılda betaCoV'ların neden olduğu üç salgın yaşadı: 2002−03'te SARS, 2012'de MERS ve 2019'da ilk kez tanımlanan COVID-19. COVID-19 güncel sağlık problemimiz olarak devamlılığını sürdürmekte ve konuyla ilgili çalışmalar devam etmektedir.

Sonuç ve Tartışma: "Antiviral ajanlar" terimi, virüs içeren aşı veya spesifik antikor dışındaki, virüs bulaşmış konakçının net saptanabilir etkisi için koruyucu veya terapötik bir etki üretebilen maddeler olarak çok geniş terimlerle tanımlanmıştır. Doğa güçlü antiviral etkiye sahip çok sayıda farklı bitki türü ile insanlığın virüsler karşısındaki çaresizliğine derman olma potansiyeline sahiptir. Antiviral etkiye sahip bitkilerin taranması sırasında, halk tıbbında kullanılan bitkilere odaklanmak, değerli kadim bilgiyi bilimsel bir zeminde ele alarak insanlığa sağlanacak yararı en üst düzeye çıkarmak- zaman ve emek tasarrufu sağlamak açısından büyük önem taşır. Bu derlemede viral hastalıklar ve bu hastalıklarda kullanılan, etkili olduğu belirlenen bitkilerden bahsedilmiştir.

Anahtar Kelimeler

HIV/AIDS, herpes simplex, influenza, koronavirüs, viral hepatit

ANTIVIRAL HERBS

Öz

Objective: Viruses are agents that can infect all kinds of living organisms, and the most important hosts are humans, animals, plants, bacteria and fungi. Viral diseases are responsible for serious morbidity and mortality worldwide, are a major threat to public health, and remain a major problem worldwide. The recently prominent Coronaviruses (CoVs) within this group belong to the Coronaviridae family, subfamily Coronavirinae, and are large (genome size 26−32 kb), enveloped, single-stranded ribonucleic acid (RNA ) viruses that can infect both animals and humans. The world has experienced three epidemics caused by betaCoVs in the last two decades: SARS in 2002−03, MERS in 2012, and COVID-19, first identified in 2019. COVID-19 continues to be our current health problem and studies on the subject continue.

Result and Discussion: The term "antiviral agents" is defined in very broad terms as substances other than virus-containing vaccine or specific antibody that can produce a protective or therapeutic effect for the clearly detectable effect of the infected host.

Nature has the potential to cure humanity's helplessness against viruses with many different plant species with strong antiviral effects. During the screening of plants with antiviral effects, focusing on plants used in folk medicine is of great importance in terms of maximizing the benefit to humanity - saving time and effort by dealing with valuable ancient knowledge on a scientific basis.

In this review, viral diseases and the plants used in these diseases and determined to be effective are mentioned.

Anahtar Kelimeler

HIV/AIDS, herpes simplex, influenza, coronavirus, viral hepatitis

Kaynakça

• [1]Waziri, Hoda M. A. (2015). Plants as antiviral agents. Journal of Plant Pathology & Microbiology 6-2.
• [2]Pushpa, R., Nishant, R., Navin, K., Pankaj, G. (2013). Antiviral potential of medicinal plants:an overview. International Research Journal Pharmacy 4(6).
• [3]Muhktar, M., Arshad, M., Ahmad, M., Pomerantz, J. R., Wigdahl, B., Parveen, Z. (2008). Antiviral potentials of medicinal plants. Virüs Research 131 111-120.
• [4]Abonyi, D. O., Adikwu, M. U., Esimone, C. O., Ibezim, E. C. (2009). Plants as sources of antiviral agents. African Journal of Biotechnology Vol. 8 (17), pp. 3989-3994. [5]Akgül, Ö., Çalışkan, R., Öner, Y.A. (2018). HIV/AIDS güncel yaklaşımlar. Tıp Fakültesi Klinikleri Dergisi Cilt 1, Sayı 1, 19 - 31, 01.04.2018 https://dergipark.org.tr/tr/pub/atk/issue/38771/451148.
• [6]Chen, Z., Wang, N., Huang Y., Wang M. (2019). Clinical characteristics and cerebro-spinal fluid cytokine changes in patients with acquired immunodeficiency syndrome and central nervous system infection. Experimental and Therapeutic Medicine 18: 523-530.
• [7]Jiang, Y., Feng, H., Lin, Y., Guo, X. (2016). New strategies against drug resistance to herpes simplex virus. International Journal of Oral Science 8, 1-6.
• [8]Zhang, K., Lv, D., Li, R. (2019). Conserved herpesvirus protein kinases target samhd1 to facilitate virus replication. Cell Reports 449-459.e5.
• [9]Rooney, B. V., Crucian, B. E., Pierson, D. L., Laudenslager, M.L., Mehda, S. K. (2019). Herpes virus reactivation in astronauts during spaceflight and its application on earth. Frontiers in Microbiology. [CrossRef]
• [10]Li, T., Peng, T. (2013). Traditional chinese herbal medicine as a source of molecules with antiviral activity. Antiviral Research 97 1–9.
• [11]Hoffmann, J., Gendrisch, F., Schempp, C. M., Wölfle, U. (2020). New herbal biomedicines for the topical treatment of dermatological disorders. Biomedicines 8 (2): 27.
• [12]Hassan, T.S. Sherif. (2020). Shedding light on the effect of natural anti-herpesvirus alkaloids on sars-cov-2: a treatment option for covid-19. Journal List Viruses v. 12(4).
• 30 Xxxx ve ark. Ankara Ecz. Fak. Derg., xx(x): xx-xx, 20xx
• [13]Kaygusuz, S., Gül, S. (2018). Grip ve aşı. Kırıkkale Üniversitesi Tıp Fakültesi Dergisi Cilt 20, Sayı 3, 329 - 344, 30.12.2018 https://dergipark.org.tr/tr/pub/kutfd/issue/38688/500424.
• [14]Krammer, F., Smith, G. J. D., Fouchier, R. A. M., Peiris, M., Kedzierska, K., Doherty, P. C., Palese, P., Shaw, M. L., Treanor, J., Webster, R. G., García-Sastre, A. (2018). Influenza. Nature Reviews Disease Primers 4:3.
• [15]Mehrbod, P., Ebrahimi, S. N., Fotouhi, F., Eskandari, F., Eloff, J. N., McGaw, L. J., Fasina, F. O. (2019). Experimental validation and computational modeling of anti-influenza effects of quercetin-3-o-α-l-rhamnopyranoside from indigenous south african medicinal plant rapanea melanophloeos. BMC Complementary and Alternative Medicine 346.
• [16]Li, Y., Lai, C., Su, M., Cheng, J., Chang, Y. (2019). Antiviral activity of portulaca oleracea l. against influenza a viruses. Journal of Ethnopharmacology. [CrossRef]
• [17]Loader, M., Movarek, R., Witowski, S. E., Driscoll L.M. (2019). A clinical review of viral hepatitis. JAAPA 32(11):15- 20.
• [18]Masood, U., John S. (2020). Hepatitis D. StatPearls Publishing LLC.
• [19]Yin, X., Feng, Z. (2019). Hepatitis e virus entry. Viruses 11(10):883.
• [20]Nishide, M., Ikeda, K., Mimura, H., Yoshida, M., Mitani, T., Koyama, A. H. (2019). Antiviral and virucidal activities against herpes simplex viruses of umeshu phenolics extracted from japanese apricot. Microbiology ve Immunology 359-366.
• [21]Anbazhagan, G.K., Palaniyandi, S., Joseph, B. (2019). Antiviral plant extracts. IntechOpen. [CrossRef]
• [22]Mani, J. S., Johnson, J. B., Steel, J. C., Broszczak, D. A., Neilsen, P. M., Walsh, K. B., Naiker M. (2020). Natural product-derived phytochemicals as potential agents against coronaviruses: a review. Virus Research 284 197989.
• [23]Fan, Y., Zhang, Y., Tariq, A., Jiang, X., Ahamd, Z., Zhihao, Z., Idrees, M., Azizullah, A., Adnan, M., Bussmann, R. W. (2020). Food as medicine: a possible preventive measure against coronavirus disease (covid-19). Phytotherapy Research. [CrossRef]
• [24]Zhang, D., Wu, K., Zhang, X., Deng, S., Peng, B. (2020). In silico screening of chinese herbal medicines with the potential to directly inhibit 2019 novel coronavirus. Journal of Integrative Medicine 18 152–158.
• [25]Orhan, I. E., Deniz, F. S. S. (2020). Natural products as potential leads against coronaviruses: could they be encouraging structural models against sars‐cov‐2?. Natural Products and Bioprospecting. [CrossRef]
• 31 Ankara Ecz. Fak. Derg., xx(x): xx-xx, 20xx Xxxx ve ark.
• [26]Yonesi, M., Rezazadeh, A. (2020). Plants as a prospective source of natural anti-viral compounds and oral vaccines against covid-19 coronavirus. Researchgate. [CrossRef]
• [27]Vellingiri, B., Jayaramayya, K., Iyer, M., Narayanasamy, A., Govindasamy, V., Giridharan, B., Ganesan, S., Venugopal, A., Venkatesan, D., Ganesan, H., Rajagopalan, K., Rahman, P., Cho, S., Kumar, N. S., Subramaniam, M. D. (2020). COVID-19: a promising cure for the global panic. Sci Total Environ 725: 138277.
• [28]Keyaerts, E., Vijgen, l., Pannecoque, C., Damme, E. V., Peumans, W., Egberink, H., Balzarini, J., Rast, V.N. (2007). Plant lectins are potent inhibitors of coronaviruses by interfering with two targets in the viral replication cycle. Antiviral Research 75 179–187.
• [29]Yang, Y., Islam, M., S., Wang, J., Li, Y., Chen, X. (2020). Traditional chinese medicine in the treatment of patients infected with 2019-new coronavirus (sars-cov-2): a review and perspective. International Journal of Biological Sciences 16(10): 1708-1717.
• [30]Rattanapisit, K., Shanmugaraj, B., Manopwisedjaroen, S., Purwono, P., Siriwattananon, K., Khorattanakulchai, N., Hanittinan, O., Boonyayothin, W., Thitithanyanont, A., Smith, D., Phoolcharoen, W. (2020). Rapid and scalable production of functional anticoronavirus monoclonal antibody cr3022 in plants. Research square. [CrossRef]
• [31]Barati, F., Pouresmaieli, M., Ekrami, E., Asghari, S., Ziarani, F., R., Mamoudifard, M. (2020). Potential drugs and remedies for the treatment of covid-19: a critical review. Biological Procedures Online 22, Article number 15.