KOMBİNE SALİSİLİK ASİT VE POVİDON-İYOT İÇEREN NANOEMÜLJELLERİN HAZIRLANMASI VE KARAKTERİZASYONU: ÖN ÇALIŞMA

Öz

Amaç: Bu ön çalışmanın amacı, gelecekte yapılması planlanan yara ve yanık gibi hastalık modellerinde kullanılmak üzere kombine salisilik asit ve povidone-iyot içeren nanoemüljeller hazırlamak ve karakterize etmektir.
Gereç ve Yöntem: Çalışma kapsamında öncelikle salisilik asitin analitik yöntem validasyonu yapılmıştır. Daha sonra yağda çözünürlük çalışması yapılıp, nanoemülsiyonlar ve nanoemüljeller hazırlanmıştır. Hazırlanan formülasyonların karakterizasyonunu belirlemek için morfoloji, zetasizer analizi, tip ve pH tayini, FTIR analizi, yayılabilirlik ve in vitro salım çalışmaları yapılmıştır.
Sonuç ve Tartışma: Nanoemülsiyonlar ve nanoemüljeller başarıyla hazırlanmıştır. Küresel damlacık yapısına sahip dış fazı su olan nanoemülsiyonlar elde edilmiştir ve morfolojileri ile zetasizer sonuçları uyumlu çıkmıştır. Yapılan 1 aylık stabilite çalışmasında sadece F1 formülasyonunda ayrışma gerçekleşmemiştir. Bekletme sonrasında pH’larda fazla değişim olmamıştır. FTIR analizi sonunda maddeler arasında etkileşimin olmadığı görülmüştür. pH 5.5 fosfat tamponuyla yapılan salım çalışmasında 8 saat sonunda yaklaşık % 40 oranında salım gerçekleşmiştir. Bu çalışma bir ön çalışma olup ilerde daha detaylı çalışmalar yapılarak uzun süreli stabiliteye ve salım oranına sahip formülasyonlar geliştirilebilir. Salisilik asit ve povidon-iyot ilk defa kombine halde kullanılmıştır. Bu kombinasyon gelecekte cilt hastalıkları için faydalı olabilecek formülasyonlara dönüştürülebilir.

Anahtar Kelimeler

• Cilt hastalıkları
• karakterizasyon
• nanoemüljel
• povidon-iyot
• salisilik asit

PREPARATION AND CHARACTERIZATION OF COMBINED SALICYLIC ACID AND POVIDONE-IODINE CONTAINING NANOEMULGELS: A PRELIMINARY STUDY

Öz

Objective: The aim of this preliminary study is to prepare and characterize combined salicylic acid and povidone-iodine-containing nanoemulgels for use in disease models such as wounds and burns in the future.
Material and Method: Within the scope of the study, first of all, analytical method validation of salicylic acid was performed. Then, oil solubility studies were carried out and nanoemulsions and nanoemulgels were prepared. Morphology, zetasizer analysis, type and pH determination, FTIR analysis, spreadability, and in vitro release studies were performed to determine the characterization of the formulations.
Result and Discussion: Nanoemulsions and nanoemulgels have been prepared successfully. Nanoemulsions with spherical droplet structure and outer phase water were obtained, and their morphology and zeta sizer results were compatible. In the 1-month stability study, only the F1 formulation did not decompose. There was not much change in pH after holding. At the end of the FTIR analysis, it was seen that there was no interaction between the items. In the release study performed with pH 5.5 phosphate buffer, approximately 40% of the release occurred after 8 hours. This study is a preliminary study, and formulations with long-term stability and release rate can be developed by conducting more detailed studies in the future. Salicylic acid and povidone-iodine were used in combination for the first time. This combination can be translated into formulations that may be beneficial for skin diseases in the future. 

Anahtar Kelimeler

• Characterization
• nanoemulgel
• povidone-iodine
• salicylic acid
• skin diseases

Kaynakça

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