KURUTMA SICAKLIĞININ KURKUMİN VE PİPERİN ÇÖZÜNMESİNE VE KATI DİSPERSİYON BAZLI MİKROPARTİKÜLLERİN SALINIM KİNETİĞİNE ETKİLERİ: BİR ÖN ÇALIŞMA

Öz

Amaç: Kurkuminin farmasötik bir ajan olarak geliştirilmesindeki en büyük zorluklardan biri, oral uygulamadan sonra düşük biyoyararlanımıdır. Kurkumin-piperin'in katı dispersiyon (KD) yaklaşımı kullanılarak birlikte uygulanmasının kurkumin çözünmesini ve biyoyararlanımını artırdığı gösterilmiştir. Püskürtmeli kurutma sırasında işlem sıcaklığının etkisinin anlaşılması, KD preparatlarında çok önemlidir; bu çalışmanın amacı, püskürtmeli kurutucunun giriş sıcaklığının çözünme davranışı ve çözünmenin en uygun kinetik modeli üzerindeki etkisini araştırmaktır. Gereç ve Yöntem: KD tozu, giriş sıcaklığı değiştirilerek (105°C; 115°C; 125°C) ve taşıyıcı olarak polivinil alkol (PVA) kullanılarak püskürtmeli kurutma yöntemi ile hazırlanmıştır. KD, %30 Curcuma longa ve %10 Piper nigrum ekstraktları kullanılarak hazırlanmıştır. Püskürtmeli kurutma işleminden elde edilen kurutulmuş tozun verimi (%) izlenmiş ve kurkumin ve piperinin çözünme davranışı, çözünme etkinliği (ÇE) değeri kullanılarak analiz edilmiştir. Ayrıca, kurkumin ve piperinin çözünmeden salınım mekanizmasını tanımlayan matematiksel model bir DDSolver yazılımı kullanılarak değerlendirilmiştir. Sonuç ve Tartışma: Püskürtmeli kurutucuda kurutma sıcaklığının değişimi, C. longa ve P. nigrum ekstresi içeren PVA bazlı KD'nin çözünme davranışını ve % verimini etkilemektedir. Kurkumin ve piperin için kinetik salınımın en ideal matematiksel modeli, çözünme mekanizmasının PVA partikülü ile çevreleyen ortam arasındaki bir boşluktan difüzyon olduğunu gösteren Kuadratik modeldir.

Anahtar Kelimeler

• Curcuma longa
• çözünme
• DDSolver
• katı dispersiyon
• Piper nigrum

Proje Numarası

007 Penel./LPPM-USD/II/2022

EFFECTS OF DRYING TEMPERATURE ON CURCUMIN AND PIPERINE DISSOLUTION AND THE RELEASE KINETICS OF SOLID DISPERSION-BASED MICROPARTICLES: A PRELIMINARY STUDY

Öz

Objective: One of the major challenges in developing curcumin as a pharmaceutical agent is its low bioavailability after oral administration. Co-administration of curcumin-piperine combined with employing solid dispersions (SD) approach has been shown to enhance curcumin dissolution and bioavailability. Understanding the influence of the processing temperature during spray drying is crucial in SDs preparations; the purpose of this study is to inquire the effect of inlet temperature spray-dryer on dissolution behavior and the best-fit kinetic model of dissolution itself. Material and Method: The SD powder was prepared using a spray-drying method by varying the inlet temperature (105°C; 115°C; 125°C) and involved polyvinyl alcohol (PVA) as a carrier. The SD were prepared at 30% Curcuma longa and 10% Piper nigrum extracts. Yield (%) of the dried powder resulted from the spray drying process was monitored, and dissolution behavior of curcumin and piperine were analyzed using a dissolution efficiency (DE) value. Furthermore, mathematical model describing the release mechanism of curcumin and piperine from the dissolution were evaluated using a DDSolver software. Result and Discussion: The variation of drying temperature on the spray dryer affects the dissolution behavior and the % yield of the PVA-based SD containing C. longa and P. nigrum extract. The most ideal mathematical model of kinetic release for curcumin and piperine were the Quadratic model, indicating that the mechanism of dissolution is diffusion through a gap between the PVA particle and the surrounding medium.

Anahtar Kelimeler

• Curcuma longa
• DDSolver
• dissolution
• Piper nigrum
• solid dispersion

Destekleyen Kurum

Sanata Dharma University

Proje Numarası

007 Penel./LPPM-USD/II/2022

Teşekkür

Sanata Dharma University of Center for Research and Community Services

Kaynakça

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