SALVIA VERTICILLATA L., ACHILLEA BIEBERSTEINII AFAN., TRAGOPOGON AUREUS BOISS. VE CEPHALARIA PROCERA FISCH. & AVÉ-LALL.’NIN HEMOSTATİK PERFORMANSLARININ İN VİTRO DEĞERLENDİRİLMESİ

Öz

Amaç: Hemostaz, kanamayı önlemek veya durdurmak için doğal bir işlev ve doğal bir süreçtir. Günümüzde kanama kontrolü için yeni, ekonomik ve yüksek performanslı ürünler geliştirmek için büyük çaba sarf edilmektedir. Bu çalışmada, halk hekimliğinde farklı amaçlarla kullanılan Salvia verticillata, Achillea biebersteinii, Tragopogon aureus ve Cephalaria procera gibi dört farklı bitki türünün in vitro hemostatik etkilerini değerlendirmeyi amaçladık. Gereç ve Yöntem: Farklı polaritelerde ekstreler hazırlandı ve hemostatik etkinlikleri optik agregometri kullanılarak belirlendi. Sonuç ve Tartışma: Mevcut sonuçlar, diğer bitki özleri ile karşılaştırıldığında S. verticillata ekstrelerinin adenozin-difosfat (ADP) (%80.77), kollajen (%80.78) ve araşidonik asit (AA) (%73.71) varlığında trombosit agregasyonu üzerinde en yüksek etkinliği gösterdiğini açıkça ortaya koymuştur. Yine epinefrin (EPI) varlığında en etkili trombosit agregasyonu (%47.27) C. procera uygulamasından sonra belirlendi. Ayrıca, öncelikle etil asetat ekstrelerinin APD, kollajen, AA ve EPI olgusunda en yüksek trombosit agregasyonu yüzdelerini göstermiştir. Sonuç olarak, bulgularımız, özellikle S. verticillata ve C. procera'nın etkili hemostatik ajanların yeni ve doğal kaynakları olabileceğini gösterdi.

Anahtar Kelimeler

• Achillea biebersteinii
• Cephalaria procera
• hemostaz
• Salvia verticillata
• Tragopogon aureus

IN VITRO ASSESSMENT OF HEMOSTATIC PERFORMANCES OF SALVIA VERTICILLATA L, ACHILLEA BIEBERSTEINII AFAN., TRAGOPOGON AUREUS BOISS., AND CEPHALARIA PROCERA FISCH. & AVÉ-LALL.

Öz

Objective: Hemostasis is an inherent function and natural process to prevent or stop bleeding. Nowadays great efforts are being made to develop novel, economical and high-performance products to control bleeding. In this study, we aimed to assess the in vitro hemostatic effects of four several plant species used in folk medicine for different purposes including Salvia verticillata, Achillea biebersteinii, Tragopogon aureus, and Cephalaria procera. Material and Method: The extracts with different solvent nature were prepared and their hemostatic efficacy were determined using optical aggregometry. Result and Discussion: The present results clearly revealed that the extracts of S. verticillata showed the highest efficacy on platelet aggregation in presence of adenosine-diphosphate (ADP) (80.77%), collagen (80.78%), and arachidonic acid (AA) (73.71%) when compared to other plant extracts. Again, the most effective platelet aggregation (47.27%) was determined after the application C. procera within the presence of epinephrine (EPI). Moreover, we first executed that ethyl acetate extracts led to the highest percentages of platelet aggregation in the fact of APD, collagen, AA and EPI. In a conclusion, our findings suggested that the tested medicinal plants in particular S. verticillata and C. procera could be novel and natural sources of effective hemostatic agents.

Anahtar Kelimeler

• Achillea biebersteinii
• Cephalaria procera
• hemostasis
• Salvia verticillata
• Tragopogon aureus

Kaynakça

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