ANKSİYETE VE UYKU BOZUKLUKLARINDA KULLANILAN TIBBİ BİTKİLER

Öz

Amaç: Anksiyete ve uyku bozuklukları ülkemizde ve dünyada son yıllarda giderek yaygınlaşan psikiyatrik hastalıklardandır. Anksiyete ve uyku bozukluğu olan bireyler hastalıklarının esas tedavisi olan farmakoterapi ve psikoterapiye ek olarak farklı tamamlayıcı tedavi arayışlarına yönelmektedir. Bu tamamlayıcı tedavi yöntemleri arasında en sık başvurulan kaynakların tıbbi bitkiler olduğu kaçınılmaz bir gerçektir. Fakat bu ürünlerin “yan etkisi daha az/daha zararsız/daha etkili” olabileceği düşüncesi gözden geçirilmesi gereken önemli bir konudur. Bu derlemede anksiyete ve uyku bozukluklarında kullanılan tıbbi bitkilerin PubMed, Science Direct, Google Akademik, BioMed Central, TÜBİTAK Ulakbim veri tabanlarında detaylı bir literatür taraması ile belirlenmesi, en sık kullanılanlarının ise hastalıklar üzerindeki potansiyel etki mekanizmalarının incelenmesi ve olumlu/olumsuz etkilerinin ortaya konması amaçlanmıştır. Sonuç ve Tartışma: Literatürdeki çalışmalar değerlendirildiğinde; anksiyete ve uyku bozukluklarında kullanılan tıbbi bitkilerin fazlalığına rağmen birçoğunun potansiyel etki mekanizması ve olumlu/olumsuz etkileri tam olarak ortaya konmamıştır. Bu bitkilerin yanlış ve bilinçsizce kullanımı hastalığın seyrinin kötüleşmesine yol açabileceğinden anksiyete ve uyku bozukluklarında kullanılan tıbbi bitkilerin incelendiği daha fazla araştırmaya ihtiyaç duyulmaktadır.

Anahtar Kelimeler

• Anksiyete
• tıbbi bitkiler
• uyku bozuklukları

MEDICINAL HERBS USED IN ANXIETY AND SLEEP DISORDERS

Öz

Objective: Anxiety and sleep disorders are psychiatric diseases that have become increasingly common in our country and in the world in recent years. Individuals with anxiety and sleep disorders tend to seek different complementary therapies in addition to pharmacological treatment, which is the main treatment of their disease It is an inevitable fact that the most frequently used sources among these complementary treatment methods are medicinal herbs. However, the idea that these products may have "less side effects / less damage/ more effect" is an important issue that needs to be reviewed. In this review, the medicinal plants used in anxiety and sleep disorders are determined by a detailed literature review in PubMed, Science Direct, Google Scholar, BioMed Central, TUBITAK Ulakbim databases, and to examine the potential mechanisms of action of the most frequently used ones on diseases and to reveal their positive/negative effects. Result and Discussion: When the studies in the literature are evaluated; Despite the abundance of medicinal herbs used in anxiety and sleep disorders, the potential mechanism of action and positive/negative effects of many of them have not been fully revealed. Since the wrong and irrational use of these herbs may lead to worsening of the course of the disease, more researches are needed to examine examine medicinal herbs used in anxiety and sleep disorders.

Anahtar Kelimeler

• Anxiety
• medicinal herbs
• sleep disorders

Kaynakça

1. 1. Kleiner, S.M. (1995). The true nature of herbs. The Physician and Sportsmedicine, 23, 13-14. [CrossRef]
2. 2. Newan, D.J., Cragg, G.M. (2020). Natural products as sources of new drugs over the nearly four decades from 01/1981 to 09/2019. Journal of Natural Products, 83, 770-803. [CrossRef]
3. 3. Yeung, K.S., Hernandez, M., Mao, J.J., Haviland, I., Gubili, J. (2018). Herbal medicine for depression and anxiety: A systematic review with assessment of potential psycho-oncologic relevance. Phytotherapy Research, 32(5), 865-891. [CrossRef]
4. 4. Şahin, M. (2019). Korku, kaygı ve kaygı (anksiyete) bozuklukları. Avrasya Sosyal ve Ekonomi Araştırmaları Dergisi, 6(10), 117-135.
5. 5. Zhang, W., Yan, Y., Wu, Y., Yang, H., Zhu, P., Yan, F., Zhao, R., Tian, P., Wang, T., Fan, Q. (2022). Medicinal herbs for the treatment of anxiety: A systematic review and network meta-analysis. Pharmacological Research, 179, 106204. [CrossRef]
6. 6. Kafes, A.Y. (2021). Depresyon ve anksiyete bozuklukları üzerine bir bakış. Humanistic Perspective, 3(1), 186-194. [CrossRef]
7. 7. Thibaut, F. (2017) Anxiety disorders: A review of current literature. Dialogues in Clinical Neuroscience, 19(2), 87-88. [CrossRef]
8. 8. Szuhany, K.L., Simon, N.M. (2022). Anxiety disorders: A review. The Journal of the American Medical Association, 328(24), 2432–2445. [CrossRef]

9. 9. Mishra, P., Kannojia, P., Sahai, D., Khan, M.A. (2019). Interaction of herbal formulation and conventional drug on anxiolytic potential in mice. Asian Journal of Pharmacy and Pharmacology, 5(2), 266-271. [CrossRef]
10. 10. Craske, M., Stein, M., Eley, T., Milad, M.R., Holmes, A., Rapee, R.M., Wittchen H.U. (2017). Anxiety disorders. Nature Reviews Disease Primers, 3, 17024.
11. 11. Remes, O., Brayne, C., van der Linde, R., Lafortune, L. (2016). A systematic review of reviews on the prevalence of anxiety disorders in adult populations. Brain and Behavior, 6(7), e00497. [CrossRef]
12. 12. Erica McIntyre, E., Saliba, A.J., Wiener K.K.K., Sarris, J. (2015). Prevalence and predictors of herbal medicine use in adults experiencing anxiety: A critical review of the literature. Advances in Integrative Medicine, 2(1), 38-48. [CrossRef]
13. 13. Romanazzo, S., Mansueto, G., Cosci, F. (2022). Anxiety in the medically Ill: A systematic review of the literature. Frontiers in Psychiatry, 13, 1-12. [CrossRef]
14. 14. Lakhan, S.E., Vieira, K.F. (2010). Nutritional and herbal supplements for anxiety and anxiety-related disorders: Systematic review. Nutrition Journal, 7(9), 42. [CrossRef]
15. 15. Ernst, E. (2006). Herbal remedies for anxiety – a systematic review of controlled clinical trials. Phytomedicine, 13(3), 205-208. [CrossRef]
16. 16. Kwon, C.H., Lee, B., Sun-Yong, C., Kim, J.W. (2019). Herbal medicine for post-stroke anxiety: A systematic review and meta-analysis of randomized controlled trials. Complementary Therapies in Clinical Practice, 35, 237-252. [CrossRef]
17. 17. Casteleijn, D., Steel, A., Bowman, D., Lauche, R., Wardle, J. (2019). A naturalistic study of herbal medicine for self-reported depression and/or anxiety a protocol. Integrative Medicine Research, 8(2), 123-128. [CrossRef]
18. 18. Bora, İ.H., Bican, A. (2007). Uyku fizyolojisi. Türkiye Klinikleri Cerrahi Tıp Bilimleri Dergisi, 3(23), 1-6.
19. 19. Algın İlhan, D., Akdağ, G., Erdinç, O.O. (2016). Kaliteli uyku ve uyku bozuklukları. Osmangazi Tıp Dergisi, 38(1), 29-34. [CrossRef]
20. 20. Hombali, A., Seow, E., Yuan, Q., Chang, S.H.S., Satghare, P., Kumar, S., Verma, S.K., Mok, Y.M., Chong, A.S., Subramaniam, M. (2019). Prevalence and correlates of sleep disorder symptoms in psychiatric disorders. Psychiatry Research, 279, 116-122. [CrossRef]
21. 21. Pavlova, M.K., Latreille, V. (2019). Sleep disorders. The American Journal of Medicine, 132(3), 292-299. [CrossRef]
22. 22. Bukhari, M.A.A., Alghtani, M.A.M., Aljohani, Z.S., Qasem, A.A.A., Alhazmi, I.H.M. (2021). Diagnosis and treatment of sleep disorders: A brief review. International Journal of Medicine in Developing Countries, 5(1), 364-369. [CrossRef]
23. 23. Strickland, S.R. (2023). Sleep disorders. InnovAiT, 16(1), 27-33. [CrossRef]
24. 24. Genç, S. (2017). The new classification of sleep disorders (ICSD-3): The changes in the classification of sleep related breathing disorder with ICSD-3. The Medical Journal of Mustafa Kemal University, 8(32), 23-32. [CrossRef]
25. 25. Abad, V.C., Guilleminault, C. (2005). Sleep and psychiatry. Dialogues in Clinical Neuroscience, 7(4), 291-303. [CrossRef]
26. 26. Sher, L. (2020). COVID-19, anxiety, sleep disturbances and suicide. Journal of Clinical Sleep Medicine, 70, 124. [CrossRef]
27. 27. Borrás, S., Martínez-Solís, I., Ríos, J.L. (2021). Medicinal plants for insomnia related to anxiety: An updated review. Planta Medica, 87(10/11), 738-753. [CrossRef]
28. 28. Sarris, J., Panossian, A., Schweitzer, I., Stough, C., Scholey, A. (2011). Herbal medicine for depression, anxiety and insomnia: A review of psychopharmacology and clinical evidence. European Neuropsychopharmacology, 21(12), 841-860. [CrossRef]
29. 29. Motti, R., de Falco, B. (2021). Traditional herbal remedies used for managing anxiety and insomnia in Italy: An ethnopharmacological overview. Horticulturae, 7(12), 523. [CrossRef]
30. 30. Khanum, F., Razack S. (2010). Anxiety- herbal treatment: A review. Research and Reviews in Biomedicine and Biotechnology, 2(1), 77-89.
31. 31. Saki, K. (2018). Treatment of anxiety disorders with plants and herbs. International Journal of Green Pharmacy, 12(3), S458.
32. 32. Sahoo, S., Brijesh S. (2019). Pharmacogenomic assessment of herbal drugs in affective disorders. Biomedicine & Pharmacotherapy, 109, 1148-1162. [CrossRef]
33. 33. Haque, E., Ahmed, F., Chaurasiya, P., Yadav, N., Dhiman, N., Maity, M.K. (2023). A review on antidepressant effect of herbal drugs. Journal of Pharmaceutical Negative Results, 14(2), 2716-2723. [CrossRef]
34. 34. Ji, X., Ivers, H., Beaulieu-Bonneau, S., Morin, C.M. (2021). Complementary and alternative treatments for insomnia/insomnia -depression-anxiety symptom cluster: Meta-analysis of English and Chinese literature. Sleep Medicine Reviews, 58, 101445. [CrossRef]
35. 35. Haghjoo, E., Shoja, A, Parvizi, M.M. (2019). Efficacy of topical herbal remedies for insomnia in Iranian traditional medicine. Pharmacognosy Research, 11(2), 188-191. [CrossRef]
36. 36. Tanker, N., Koyuncu, M., Coşkun, M. (2021). Farmasötik Botanik, (pp. 93-366), Ankara: Ankara Üniversitesi Basımevi.
37. 37. Feizi, F., Namazi, N., Rahimi, R., Ayati, M.H. (2019). Medicinal plants for management of insomnia: A systematic review of animal and human studies. Galen Medical Journal, 1(8), e1085. [CrossRef]
38. 38. Demirezer, Ö., Ersöz, T., Saraçoğlu, İ., Şener, B., Köroğlu, A., Yalçın, F.N. (2017). FFD Monografları, (pp. 1-1097), Akademisyen Kitapevi, Ankara.
39. 39. Muzammil, M., Satish, S., Gafoor, H. (2020). A systematic review on natural sedative and hypnotics. International Journal of Pharmaceutical Sciences Review and Research, 18, 94-98.
40. 40. Baytop, T. (1999). Türkiye’de Bitkiler ile Tedavi, Geçmişte ve Bugün. (pp. 137-376), Nobel Tıp Kitapevi, İstanbul.
41. 41. Güner, A., Aslan, S., Ekim, T., Vural, M., Babaç, M.T., (edlr.), (2012). Türkiye Bitkileri Listesi (Damarlı Bitkiler), (pp.1-897), Nezahat Gökyiğit Botanik Bahçesi ve Flora Araştırmaları Derneği Yayını. İstanbul.
42. 42. Fajemiroye, J.O., da Silva, D.M., de Oliveira, D.R. and Costa, E.A. (2016), Treatment of anxiety and depression: medicinal plants in retrospect. Fundam Clin Pharmacol, 30, 198-215. [CrossRef]
43. 43. Sarris, J., Panossian, A., Schweitzer, I., Stough, C., Scholey, A. (2011). Herbal medicine for depression, anxiety and insomnia: A review of psychopharmacology and clinical evidence. European Neuropsychopharmacology, 21(12), 841-860. [CrossRef]
44. 44. Ross, S.M. (2014). Psychophytomedicine: An overview of clinical efficacy and phytopharmacology for treatment of depression, anxiety and insomnia. Holistic Nursing Practice, 28(4), 275-280. [CrossRef]
45. 45. Baek, J.H., Nierenberg, A.A., Kinrys, G. (2014). Clinical applications of herbal medicines for anxiety and insomnia; targeting patients with bipolar disorder. Australian & New Zealand Journal of Psychiatry, 48(8), 705-715. [CrossRef]
46. 46. Kamal, M., Jawaid, T. (2011). Herbal drugs in mirror of anxiety disorder - a review. International Journal of Biomedical Research, 2(1), 62-72.
47. 47. Nandhini, S., Narayanan, K.B., Ilango, K. (2018). Valeriana officinalis: A review of its traditional uses, phytochemistry and pharmacology. Asian Journal of Pharmaceutical and Clinical Research, 11(1), 36-41. [CrossRef]
48. 48. Kamalipour, M., Akhoundzadeh, S.H., Rezazadeh, S.A. (2008). Herbal medicines in the treatment of depression and anxiety. Journal of Medicinal Plants, 7(4), 1-7. [CrossRef]
49. 49. Lakhan, S.E., Vieira, K.F. (2010). Nutritional and herbal supplements for anxiety and anxiety-related disorders: Systematic review. Nutrition Journal, 7(9), 42. [CrossRef]
50. 50. Yeung, K.S., Hernandez, M., Mao, J.J., Haviland, I., Gubili, J. (2018). Herbal medicine for depression and anxiety: A systematic review with assessment of potential psycho-oncologic relevance. Phytotherapy Research, 32(5), 865-891. [CrossRef]
51. 51. De Sousa, A. (2013). Herbal medicines and anxiety disorders: An overview. Journal of Medicinal Plants Studies, 1(6), 18-23.
52. 52. Allameh, M., Orsat, V. (2022) Herbal anxiolytics: Sources and their preparation methods. Food Reviews International, 1-28. [CrossRef]
53. 53. Sarris, J. (2018). Herbal medicines in the treatment of psychiatric disorders: 10-year updated review. Phytotherapy Research, 32, 1147-1162. [CrossRef]
54. 54. Pratte, M.A., Nanavati, K.B., Young, V., Morley, C.P. (2014). An alternative treatment for anxiety: A systematic review of human trial results reported for the Ayurvedic herb Ashwagandha (Withania somnifera). The Journal of Alternative and Complementary Medicine, 20(12), 901-908. [CrossRef]
55. 55. Speers, A.B., Cabey, K.A., Soumyanath, A., Wright, K.M. (2021). Effects of Withania somnifera (Ashwagandha) on stress and the stress-related neuropsychiatric disorders anxiety, depression, and insomnia. Current Neuropharmacology, 19(9), 1468-1495. [CrossRef]
56. 56. Fuladi, S., Emami, S.A., Mohammadpour, A.H., Karimani, A., Manteghi, A.A., Sahebkar, A. (2021). Assessment of the efficacy of Withania somnifera root extract in patients with generalized anxiety disorder: A randomized double-blind placebo- controlled trial. Current Reviews in Clinical and Experimental Pharmacology Formerly Current Clinical Pharmacology, 16(2), 191-196. [CrossRef]
57. 57. Gannon, M.A., Brar, J., Rai, A., Chengappa, K.N.R. (2021). Effects of a standardized extract of Withania somnifera (Ashwagandha) on depression and anxiety symptoms in persons with schizophrenia participating in a randomized, placebo-controlled clinical trial. Annals of Clinical Psychiatry, 32(2), 123-129.
58. 58. Ghazizadeh, J., Sadigh-Eteghad, S., Marx, W., Fakhari, A., Hamedeyazdan, S., Torbati, M., Taheri-Tarighi, S., Araj-khodaei, M., Mirghafourvand, M. (2021). The effects of lemon balm (Melissa officinalis L.) on depression and anxiety in clinical trials: A systematic review and meta-analysis. Phytotherapy Research, 35(12), 6690-6705. [CrossRef]
59. 59. Zam, W., Quispe, C., Sharifi-Rad, J., López, M.D., Schoebitz, M., Martorell, M., Sharopov, F., Tsouh Fokou, P.V., Mishra, A.P., Chandran, D., Kumar, M., Chen, J.T., Pezzani, R. (2022). An updated review on the properties of Melissa officinalis L.: Not exclusively anti-anxiety. Frontiers in Bioscience, 14(2), 16. [CrossRef]
60. 60. Araj-Khodaei, M., Noorbala, A.A., Yarani, R., Emadi, F., Emaratkar, E., Faghihzadeh, S., Parsian, Z., Alijaniha, H., Kamalinejad, M., Naseri, M. (2020). A double-blind, randomized pilot study for comparison of Melissa officinalis L. and Lavandula angustifolia Mill. with fluoxetine for the treatment of depression. BMC Complementary Medicine and Therapies, 20, 207. [CrossRef]
61. 61. Patil, S.M., Al-Mutairi K.A., Firdose, N., Ramu, R., Martiz, R.M., Ashwini, P. (2022). Pharmacoinformatics based screening discovers swertianolin from Lavandula angustifolia as a novel neuromodulator targeting epilepsy, depression, and anxiety. South African Journal of Botany, 149, 712-730. [CrossRef]
62. 62. Donelli, D., Antonelli, M., Bellinazzi, C., Gensini, G.F., Firenzuoli, F. (2019). Effects of lavender on anxiety: A systematic review and meta-analysis. Phytomedicine, 65, 0944-7113. [CrossRef]
63. 63. Kasper, S. (2013). An orally administered lavandula oil preparation (Silexan) for anxiety disorder and related conditions: An evidence based review. International Journal of Psychiatry in Clinical Practice, 17(1), 15-22. [CrossRef]
64. 64. Karan, N.B. (2019). Influence of lavender oil inhalation on vital signs and anxiety: A randomized clinical trial. Physiology & Behavior, 211, 112676. [CrossRef]
65. 65. Fajemiroye, J.O., da Silva, D.M., de Oliveira, D.R., Costa, E.A. (2016). Treatment of anxiety and depression: medicinal plants in retrospect. Fundamental & Clinical Pharmacology, 30, 198-215. [CrossRef]
66. 66. Zirak, N., Shafiee, M., Soltani, G., Mirzaei, M., Sahebkar, A. (2019). Hypericum perforatum in the treatment of psychiatric and neurodegenerative disorders: Current evidence and potential mechanisms of action. Journal of Cellular Physiology, 234, 8496-8508. [CrossRef]
67. 67. Nabavi, S.M., Silva, A.S. (2019). Nonvitamin and nonmineral nutritional supplements. St. John’s Wort (Hypericum perforatum). Academic Press, (pp. 415-432).
68. 68. Zhao, Yf., Sun, P., Ma, Y., Wang, K., Chang, X.Q., Bai, Y., Yang, L.X., Zhang, D., Yang, L. (2020). Chemical constituents of Matricaria chamomilla. Chemistry of Natural Compounds, 56, 364-365. [CrossRef]
69. 69. Keefe, J.R., Mao, J.J., Soeller, I., Li, Q.S., Amsterdam, J.D. (2016). Short-term open-label chamomile (Matricaria chamomilla L.) therapy of moderate to severe generalized anxiety disorder. Phytomedicine, 23(14), 1699-1705. [CrossRef]
70. 70. Mao, J.J., Sharon X. Xie, S.X., Keefe, J.R., Soeller, I., Li, Q.S., Amsterdam, J.D. Long-term chamomile (Matricaria chamomilla L.) treatment for generalized anxiety disorder: A randomized clinical trial. Phytomedicine, 23(14), 1735-1742. [CrossRef]
71. 71. El Joumaa, M.M., Borjac, J.M. (2022). Matricaria chamomilla: A valuable insight into recent advances in medicinal uses and pharmacological activities. Phytochemistry Reviews, 21, 1913-1940. [CrossRef]
72. 72. El Mihyaoui, A., Esteves da Silva, J.C.G., Charfi, S.; Candela Castillo, M.E., Lamarti, A., Arnao, M.B. (2022). Chamomile (Matricaria chamomilla L.): A review of ethnomedicinal use, phytochemistry and pharmacological uses. Life, 12, 479. [CrossRef]
73. 73. Singh, O., Khanam, Z., Misra, N., Srivastava, M.K. (2011). Chamomile (Matricaria chamomilla L.): An overview. Pharmacognosy Reviews, 5(9), 82-95. [CrossRef]
74. 74. Ferrara, L., Montesano, D., Senatore, A. The distribution of minerals and flavonoids in the tea plant (Camellia sinensis). Il Farmaco, 56(5), 397-401. [CrossRef]
75. 75. Sarris, J., Byrne, G.J., Cribb, L., Oliver, G., Murphy, J., Macdonald, P., Nazareth, S., Karamacoska, D., and Samantha Galea, S., Short, A., Ee, C., Birling, Y., Menon, R., Ng, C.H. (2019). L-theanine in the adjunctive treatment of generalized anxiety disorder: A double-blind, randomised, placebo-controlled trial. Journal of Psychiatric Research, 110, 31-37. [CrossRef]
76. 76. Alagarsamy, K., Shamala, L.F., Wei, S. (2018). Protocol: high-efficiency in-planta Agrobacterium-mediated transgenic hairy root induction of Camellia sinensis var. sinensis. Plant Methods, 14, 17. [CrossRef]
77. 77. Singh, S.P. (2019). A comprehensive review on pharmacological activity of Foeniculum vulgare. Global Journal of Pharmacy & Pharmaceutical Sciences, 7(1), 23-27.
78. 78. Wesam, K., Maryam, M., Sara, A.A., Naim, S.A., Majid, A.S., Damoon, A.L. (2015). Therapeutic and pharmacological potential of Foeniculum vulgare Mill: A review. Journal of Herbmed Pharmacology, 4(1), 1-9.
79. 79. Patel, V.V., Bandivdekar, A.H. (2014). Foeniculum vulgare Mill: A review of its botany, phytochemistry, pharmacology, contemporary application, and toxicology. BioMed Research International, 1-32. [CrossRef]
80. 80. Kyrou, I., Christou, A., Panagiotakos, D., Stefanaki, C., Skenderi, K., Katsana, K., Tsigos, C. (2017). Effects of a hops (Humulus lupulus L.) dry extract supplement on self-reported depression, anxiety and stress levels in apparently healthy young adults: A randomized, placebo-controlled, double-blind, crossover pilot study. Hormones, 16, 171-180. [CrossRef]
81. 81. Kenda, M., Kočevar Glavač, N., Nagy, M., Sollner Dolenc, M. (2022). Medicinal plants used for anxiety, depression, or stress treatment: An update. Molecules, 27(18), 6021. [CrossRef]
82. 82. Mahendran, G., Rahman, L.U. (2020). Ethnomedicinal, phytochemical and pharmacological updates on Peppermint (Mentha × piperita L.) A review. Phytotherapy Research. 34, 2088-2139. [CrossRef]
83. 83. Cerini Trevisan, S.C., Paes Menezes, A.P., Barbalho, S.M., Guiguer, E.L. (2017). Properties of Mentha piperita: A brief review. World Journal of Pharmaceutical and Medical Research, 3(1), 309-313. [CrossRef]