PETROSELINUM CRISPUM (MILL.) FUSS (PARSLEY), A FOOD AND MEDICINALLY IMPORTANT PLANT: A REVIEW OF RECENT STUDIES BETWEEN 2013-2023

Öz

Objective: Petroselinum crispum (Mill.) Fuss is a bright green biennial medicinal and aromatic herb that grows almost all over the world. Today, it is one of the most commonly used culinary herbs. In addition to its use as food, it has been shown to possess broad pharmacological activities in several in vivo and in vitro studies. This study aimed to comprehensively summarize the current studies on the traditional use, phytochemical composition, pharmacological activities, clinical studies, toxicity, and drug interactions of parsley. Result and Discussion: According to the literature data, parsley is used as a diuretic, carminative, emmenagogue and for the prevention and treatment of kidney stone formation, the treatment of conditions such as urinary tract infections and stomach disorders. Its phytochemical composition consists of flavonoids, coumarins, phenolic compounds, organic acids, carotenoids, vitamins, minerals, fixed oil, essential oil, and other compounds. Studies on P. crispum have shown that it has a wide range of pharmacological activities, including antioxidant, antibacterial, antifungal, antidiabetic, antihypertensive, antiplatelet, analgesic, antiinflammatory, antihepatotoxic, antinephrotoxic, anticancer, antiurolithiatic, wound healing, antiobesity, estrogenic and neuroprotective effects. This review comprehensively summarizes the scientific data of the last ten years (2013-2023) on P. crispum.

Anahtar Kelimeler

• Parsley
• Petroselinum crispum
• pharmacology
• phytochemistry
• traditional

PETROSELINUM CRISPUM (MILL.) FUSS (MAYDANOZ), GIDA VE TIBBİ OLARAK ÖNEMLİ BİR BİTKİ: 2013-2023 ARASINDAKİ SON ÇALIŞMALARIN DERLEMESİ

Öz

Amaç: Petroselinum crispum (Mill.) Fuss, neredeyse dünyanın her yerinde yetişen, iki yıllık, parlak yeşil renkli, tıbbi ve aromatik bir bitkidir. Günümüzde en çok kullanılan mutfak bitkilerinden biridir. Gıda olarak kullanımının yanı sıra çeşitli in vivo ve in vitro çalışmalarda geniş farmakolojik aktivitelere sahip olduğu gösterilmiştir. Bu çalışmada maydanozun geleneksel kullanımı, fitokimyasal bileşimi, farmakolojik aktiviteleri, klinik çalışmaları, toksisitesi ve ilaç etkileşimleri üzerine yapılan güncel çalışmaların kapsamlı bir şekilde özetlenmesi amaçlanmıştır. Sonuç ve Tartışma: Literatür verilerine göre maydanoz diüretik, karminatif, emenagog olarak, böbrek taşı oluşumunun önlenmesi ve tedavisi, idrar yolu enfeksiyonları ve mide rahatsızlıkları gibi rahatsızlıkların tedavisi için kullanılmaktadır. Fitokimyasal bileşimi flavonoitler, kumarinler, fenolik bileşikler, organik asitler, karotenoitler, vitaminler, mineraller, sabit yağ, uçucu yağ ve diğer bileşiklerden oluşmaktadır. P. crispum üzerinde yapılan çalışmalar, antioksidan, antibakteriyel, antifungal, antidiyabetik, antihipertansif, antiplatelet, analjezik, antiinflamatuar, antihepatotoksik, antinefrotoksik, antikanser, antiürolitiyatik, yara iyileştirici, antiobezite, östrojenik ve nöroprotektif etkiler dahil olmak üzere çok çeşitli farmakolojik aktivitelere sahip olduğunu göstermiştir. Bu derleme, P. crispum'a ilişkin son on yıla (2013-2023) ait bilimsel verileri kapsamlı bir şekilde özetlemektedir.

Anahtar Kelimeler

• Farmakoloji
• fitokimya
• geleneksel
• maydanoz
• Petroselinum crispum

Kaynakça

1. 1. Awe, E.O., Banjoko, S.O. (2013). Biochemical and haematological assessment of toxic effects of the leaf ethanol extract of Petroselinum crispum (Mill) Nyman ex A.W. Hill (Parsley) in rats. BMC Complementary and Alternative Medicine, 13, 75. [CrossRef]
2. 2. Ajebli, M., Eddouks, M. (2019). Antihypertensive activity of Petroselinum crispum through inhibition of vascular calcium channels in rats. Journal of Ethnopharmacology, 242, 112039. [CrossRef]
3. 3. Charles, D.J. (2012). Parsley. In: Peter, K.V. (Ed.). Handbook of Herbs and Spices. (2nd edition) (pp. 430-451). Sawston: Woodhead Publishing Limited.
4. 4. Agyare, C., Appiah, T., Boakye, Y.D., Apenteng, J.A. (2017). Petroselinum crispum: A Review. In: Victor Kuete (Ed.), Medicinal Spices and Vegetables from Africa, (pp. 527-547). Academic Press.
5. 5. World Flora Online (WFO) Web site. Petroselinum Hill, from https://wfoplantlist.org/taxon/wfo-4000028989-2023-12?page=1. Access date: 29.01.2024.
6. 6. Kew Royal Botanic Gardens, Plants of the World Online Web site. Petroselinum crispum (Mill.) Fuss, from https://powo.science.kew.org/taxon/60442790-2. Access date: 29.01.2024.
7. 7. Kew Royal Botanic Gardens, Plants of the World Online Web site. Sison segetum L., from https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:848930-1. Access date: 29.01.2024.
8. 8. Sarwar, S., Ayyub, M.A., Rezgui, M., Nisar, S., Jilani, M.I. (2016). Parsley: A review of habitat, phytochemistry, ethnopharmacology and biological activities. International Journal of Chemical and Biochemical Sciences, 9, 49-55.

9. 9. Farzaei, M.H., Abbasabadi, Z., Ardekani, M.R.S., Rahimi, R., Farzaei, F. (2013). Parsley: A review of ethnopharmacology, phytochemistry and biological activities. Journal of Traditional Chinese Medicine, 33(6), 815-826. [CrossRef]
10. 10. Taïbi, K., Aït Abderrahim, L., Boussaid, M., Taibi, F., Achir, M., Souana, K., Benaissa, T., Farhi, K.H., Naamani, F.Z., Nait Said, K. (2021). Unraveling the ethnopharmacological potential of medicinal plants used in Algerian traditional medicine for urinary diseases. European Journal of Integrative Medicine, 44, 101339. [CrossRef]
11. 11. Ginko, E., Alajmovic Demirović, E., Šarić-Kundalić, B. (2023). Ethnobotanical study of traditionally used plants in the municipality of Zavidovići, BiH. Journal of Ethnopharmacology, 302, 115888. [CrossRef]
12. 12. Gomides, N.A.M.T.P., Neto, G.G., Martins, M.P., Kato, L., Severino, V.G.P. (2022). Ethnobotanical and ethnopharmacological survey of medicinal species utilized in the Coqueiros Community, Brazil. Boletin Latinoamericano y Del Caribe de Plantas Medicinales y Aromaticas, 21(6), 671-715. [CrossRef]
13. 13. Rigat, M., Vallès, J., D׳Ambrosio, U., Gras, A., Iglésias, J., Garnatje, T. (2015). Plants with topical uses in the Ripollès district (Pyrenees, Catalonia, Iberian Peninsula): Ethnobotanical survey and pharmacological validation in the literature. Journal of Ethnopharmacology, 164, 162-179. [CrossRef]
14. 14. Kharchoufa, L., Bouhrim, M., Bencheikh, N., Addi, M., Hano, C., Mechchate, H., Elachouri, M. (2021). Potential toxicity of medicinal plants inventoried in Northeastern Morocco: An ethnobotanical approach. Plants, 10(6), 1108. [CrossRef]
15. 15. Bencheikh, N., Elbouzidi, A., Kharchoufa, L., Ouassou, H., Alami Merrouni, I., Mechchate, H., Es-safi, I., Hano, C., Addi, M., Bouhrim, M., Eto, B., Elachouri, M. (2021). Inventory of medicinal plants used traditionally to manage kidney diseases in North-Eastern Morocco: Ethnobotanical fieldwork and pharmacological evidence. Plants, 10(9), 1966. [CrossRef]
16. 16. Savikin, K., Zdunic, G., Menkovic, N., Zivkovic, J., Cujic, N., Terescenko, M., Bigovic, D. (2013). Ethnobotanical study on traditional use of medicinal plants in South-Western Serbia, Zlatibor district. Journal of Ethnopharmacology, 146(3), 803-810. [CrossRef]
17. 17. Yeşilyurt, E.B., Şimşek, I., Tuncel, T., Akaydın, G., Yeşilada, E. (2017). Marmara Bölgesi’nin bazı yerleşim merkezlerinde halk ilacı olarak kullanılan bitkiler. Marmara Pharmaceutical Journal, 21, 132-148. [CrossRef]
18. 18. Güzel, Y., Güzel, M., Miski, M. (2015). Ethnobotany of medicinal plants used in Antakya: A multicultural district in Hatay Province of Turkey. Journal of Ethnopharmacology, 174, 118-152. [CrossRef]
19. 19. Karaköse, M. (2022). An ethnobotanical study of medicinal plants in Güce district, North-eastern Turkey. Plant Diversity, 44(6), 577-597. [CrossRef]
20. 20. Şen, G., Akbulut, S., Karaköse, M. (2022). Ethnopharmacological study of medicinal plants in Kastamonu province (Türkiye). Open Chemistry, 20(1), 873-911. [CrossRef]
21. 21. Sbai, H., Saad, I., Ghezal, N., Greca, M.D., Haouala, R. (2016). Bioactive compounds isolated from Petroselinum crispum L. leaves using bioguided fractionation. Industrial Crops and Products, 89, 207-214. [CrossRef]
22. 22. de Oliveira, V.S., Chávez, D.W.H., Paiva, P.R.F., Gamallo, O.D., Castro, R.N., Sawaya, A.C.H.F., Sampaio, G.R., Torres, E.A.F.D.S., Saldanha, T. (2022). Parsley (Petroselinum crispum Mill.): A source of bioactive compounds as a domestic strategy to minimize cholesterol oxidation during the thermal preparation of omelets. Food Research International, 156, 111199. [CrossRef]
23. 23. Frattani, F.S., Assafim, M., Casanova, L.M., de Souza, J.E., Chaves, D.S.A., Costa, S.S., Zingali, R.B. (2020). Oral treatment with a chemically characterized parsley (Petroselinum crispum var. neapolitanum Danert) aqueous extract reduces thrombi formation in rats. Journal of Traditional and Complementary Medicine, 11(3), 287-291. [CrossRef]
24. 24. Takrooni, W.A., Sharaf, I.A., Abdul Majid, N.A. (2019). Assessment of the potential role of parsley (Petroselinum crispum) leaves extract in ameliorating cyclosporin A-induced nephrotoxicity in rats. International Journal of Pharmaceutical Research & Allied Sciences, 8(2),118-128.
25. 25. Proz, M. L.Á., da Silva, M.A.S., Rodrigues, E., Bender, R.J., Rios, A.O. (2021). Effects of indoor, greenhouse, and field cultivation on bioactive compounds from parsley and basil. Journal of the Science of Food and Agriculture, 101(15), 6320-6330. [CrossRef]
26. 26. Knez, E., Kadac-Czapska, K., Dmochowska-Ślęzak, K., Grembecka, M. (2022). Root vegetables-composition, health effects, and contaminants. International Journal of Environmental Research and Public Health, 19(23), 15531. [CrossRef]
27. 27. Gruszecki, R., Walasek-Janusz, M. (2022). Essential oil diversity of turnip-rooted parsley cultivars. Agronomy, 12, 1949. [CrossRef]
28. 28. Ferreira, F.S., de Oliveira, V.S., Chávez, D.W.H., Chaves, D.S., Riger, C.J., Sawaya, A.C.H.F., Guizellini, G.M., Sampaio, G.R., Torres, E.A.F.D.S., Saldanha, T. (2022). Bioactive compounds of parsley (Petroselinum crispum), chives (Allium schoenoprasum L) and their mixture (Brazilian cheiro-verde) as promising antioxidant and anti-cholesterol oxidation agents in a food system. Food Research International, 151, 110864. [CrossRef]
29. 29. Michalaki, A., Karantonis, H.C., Kritikou, A.S., Thomaidis, N.S., Dasenaki, M.E. (2023). Ultrasound-assisted extraction of specific phenolic compounds from Petroselinum crispum leaves using response surface methodology and HPLC-PDA and Q-TOF-MS/MS identification. Applied Sciences, 13(2), 798. [CrossRef]
30. 30. Wang, Y., Zhang, Y., Hou, M., Han, W. (2022). Anti-fatigue activity of parsley (Petroselinum crispum) flavonoids via regulation of oxidative stress and gut microbiota in mice. Journal of Functional Foods, 89, 104963. [CrossRef]
31. 31. El-Zaeddi, H., Calín-Sánchez, Á., Nowicka, P., Martínez-Tomé, J., Noguera-Artiaga, L., Burló, F., Wojdyło, A., Carbonell-Barrachina, Á.A. (2017). Preharvest treatments with malic, oxalic, and acetylsalicylic acids affect the phenolic composition and antioxidant capacity of coriander, dill and parsley. Food Chemistry, 226, 179-186. [CrossRef]
32. 32. Husain, I., Ahmad, R., Siddiqui, S., Chandra, A., Misra, A., Srivastava, A., Ahamad, T., Khan, M.F., Siddiqi, Z., Trivedi, A., Upadhyay, S., Gupta, A., Srivastava, A.N., Ahmad, B., Mehrotra, S., Kant, S., Mahdi, A.A., Mahdi, F. (2022). Structural interactions of phytoconstituent(s) from cinnamon, bay leaf, oregano, and parsley with SARS-CoV-2 nucleocapsid protein: A comparative assessment for development of potential antiviral nutraceuticals. Journal of Food Biochemistry, 46(10), e14262. [CrossRef]
33. 33. Seczyk, L., Swieca, M., Gawlik-Dziki, U., Luty, M., Czy, J. (2016). Effect of fortification with parsley (Petroselinum crispum Mill.) leaves on the nutraceutical and nutritional quality of wheat pasta. Food Chemistry, 190, 419-428. [CrossRef]
34. 34. Daga, P., Vaishnav, S.R., Dalmia, A., Tumaney, A.W. (2022). Extraction, fatty acid profile, phytochemical composition and antioxidant activities of fixed oils from spices belonging to Apiaceae and Lamiaceae family. Journal of Food Science and Technology, 59(2), 518-531. [CrossRef]
35. 35. Slighoua, M., Mahdi, I., Ez-Zahra Amrati, F., Di Cristo, F., Amaghnouje, A., Grafov, A., Boucetta, N., Bari, A., Bousta, D. (2021). Assessment of in vivo estrogenic and anti-inflammatory activities of the hydro-ethanolic extract and polyphenolic fraction of parsley (Petroselinum sativum Hoffm.). Journal of Ethnopharmacology, 265, 113290. [CrossRef]
36. 36. Slighoua, M., Mahdi, I., Moussaid, F.Z., Kamaly, O.A., Amrati, F.E., Conte, R., Drioiche, A., Saleh, A., Housseini, A.I., Bari, A., Bousta, D. (2023). LC-MS/MS and GC/MS profiling of Petroselinum sativum Hoffm. and its topical application on burn wound healing and related analgesic potential in rats. Metabolites, 13(2), 260. [CrossRef]
37. 37. Mert, A., Timur, M. (2017). Essential oil and fatty acid composition and antioxidant capacity and total phenolic content of parsley seeds (Petroselinum crispum) grown in Hatay region. Indian Journal of Pharmaceutical Education and Research, 51(3), 437-440. [CrossRef]
38. 38. Moni, S.S., Jabeen, A., Sanobar, S., Rehman, Z., Alam, M.S., Elmobark, M.E. (2021). Bioactive constituents and in vitro antibacterial properties of Petroselinum crispum leaves, a common food herb in Saudi Arabia. Indian Journal of Natural Products and Resources, 12(3), 445-450. [CrossRef]
39. 39. El-Assri, E.M., Hajib, A., Choukri, H., Gharby, S., Lahkimi, A., Eloutassi, N., Bouia, A. (2023). Nutritional quality, lipid, and mineral profiling of seven Moroccan Apiaceae seeds. South African Journal of Botany, 160, 23-35. [CrossRef]
40. 40. Linde, G.A., Gazim, Z.C., Cardoso, B.K., Jorge, L.F., Tesevic, V., Glamoclija, J., Sokovic, M., Colauto, N.B. (2016). Antifungal and antibacterial activities of Petroselinum crispum essential oil. Genetics and Molecular Research, 15(3), gmr.15038538. [CrossRef]
41. 41. Khalil, A.F., Elkatry, H.O., El Mehairy, H.F. (2015). Protective effect of peppermint and parsley leaves oils against hepatotoxicity on experimental rats. Annals of Agricultural Science, 60(2), 353-359. [CrossRef]
42. 42. Bouzekri, O., Elgamouz, S., El Khatabi, K., Amechrouq, A., Ajana, M.A., Bouachrine, M., Lakhlifi, T., El Idrissi, M., Choukrad, M. (2022). Chemical composition and in silico acetylcholinesterase ınhibitory activity of essential oils of six Apiaceae species from South-East Morocco. (2022). Biointerface Research in Applied Chemistry, 13(1), 36. [CrossRef]
43. 43. Foudah, A.I., Alqarni, M.H., Alam, A., Salkini, M.A., Ross, S.A., Yusufoglu, H.S. (2022). Phytochemical screening, in vitro and in silico studies of volatile compounds from Petroselinum crispum (Mill) leaves grown in Saudi Arabia. Molecules, 27(3), 934. [CrossRef]
44. 44. Gladikostić, N., Ikonić, B., Teslić, N., Zeković, Z., Božović, D., Putnik, P., Bursać Kovačević, D., Pavlić, B. (2023). Essential oils from Apiaceae, Asteraceae, Cupressaceae and Lamiaceae families grown in Serbia: Comparative chemical profiling with in vitro antioxidant activity. Plants, 12(4), 745. [CrossRef]
45. 45. Jugreet, B.S., Lall, N., Anina Lambrechts, I., Reid, A.M., Maphutha, J., Nel, M., Hassan, A.H., Khalid, A., Abdalla, A.N., Van, B.L., Mahomoodally, M.F. (2022). In vitro and in silico pharmacological and cosmeceutical potential of ten essential oils from aromatic medicinal plants from the Mascarene Islands. Molecules, 27(24), 8705. [CrossRef]
46. 46. Deepika, Chaudhari, A.K., Singh, A., Das, S., Dubey, N.K. (2021). Nanoencapsulated Petroselinum crispum essential oil: Characterization and practical efficacy against fungal and aflatoxin contamination of stored chia seeds. Food Bioscience, 42, 101117. [CrossRef]
47. 47. Jugreet, B.S., Mahomoodally, M.F. (2021). Reprint of: Essential oils from 9 exotic and endemic medicinal plants from Mauritius shows in vitro antibacterial and antibiotic potentiating activities. South African Journal of Botany, 140, 478-485. [CrossRef]
48. 48. Herrera-Calderon, O., Saleh, A.M., Mahmood, A.A.R., Khalaf, M.A., Calva, J., Loyola-Gonzales, E., Tataje-Napuri, F.E., Chávez, H., Almeida-Galindo, J.S., Chavez-Espinoza, J.H., Pari-Olarte, J.B. (2023). The essential oil of Petroselinum crispum (Mill) Fuss seeds from Peru: Phytotoxic activity and in silico evaluation on the target enzyme of the glyphosate herbicide. Plants, 12(12), 2288. [CrossRef]
49. 49. Vitalini, S., Nalbone, L., Bernardi, C., Iriti, M., Costa, R., Cicero, N., Giarratana, F., Vallone, L. (2023). Ginger and parsley essential oils: chemical composition, antimicrobial activity, and evaluation of their application in cheese preservation. Natural Product Research, 37(16), 2742-2747. [CrossRef]
50. 50. Tang, E.L., Rajarajeswaran, J., Fung, S.Y., Kanthimathi, M.S. (2015). Petroselinum crispum has antioxidant properties, protects against DNA damage and inhibits proliferation and migration of cancer cells. Journal of Science of Food and Agriculture, 95, 2763-2771. [CrossRef]
51. 51. Mara de Menezes Epifanio, N., Rykiel Iglesias Cavalcanti, L., Falcão Dos Santos, K., Soares Coutinho Duarte, P., Kachlicki, P., Ożarowski, M., Jorge Riger, C., Siqueira de Almeida Chaves, D. (2020). Chemical characterization and in vivo antioxidant activity of parsley (Petroselinum crispum) aqueous extract. Food & Function, 11(6), 5346-5356. [CrossRef]
52. 52. Farah, H., Elbadrawy, E., Al-Atoom, A.A. (2015). Evaluation of antioxidant and antimicrobial activities of ethanolic extracts of parsley (Petroselinum crispum) and coriander (Coriandrum sativum) plants grown in Saudi Arabia. International Journal of Advanced Research, 3(4), 1244-1255.
53. 53. Nadeem, A., Fatima, I., Safdar, N., Yasmin, A. (2022). Customized heating treatments variably affect the biological activities and chemical compositions of three indigenous culinary herbs. Journal of Taibah University for Science, 16(1), 120-129. [CrossRef]
54. 54. Bodea, I.M., Cătunescu, G.M., Pop, C.R., Fiț, N.I., David, A.P., Dudescu, M.C., Stănilă, A., Rotar, A.M., Beteg, F.I. (2022). Antimicrobial properties of bacterial cellulose films enriched with bioactive herbal extracts obtained by microwave-assisted extraction. Polymers, 14(7), 1435. [CrossRef]
55. 55. Sharmeen Jugreet, B., Kouadio Ibrahime, S., Zengin, G., Abdallah, H.H., Fawzi Mahomoodally, M. (2021). GC/MS profiling, in vitro and in silico pharmacological screening and principal component analysis of essential oils from three exotic and two endemic plants from Mauritius. Chemistry & Biodiversity, 18. e2000921. [CrossRef]
56. 56. Aljanaby, A.A.J.J. (2013). Antibacterial activity of an aqueous extract of Petroselinum crispum leaves against pathogenic bacteria isolated from patients with burns infections in Al-najaf Governorate, Iraq. Research on Chemical Intermediates, 39, 3709-3714. [CrossRef]
57. 57. Alshahrani, S.H., Alameri, A.A., Zabibah, R.S., Jalil, A.T.J., Ahmadi, O., Behbudi, G. (2022). Screening method synthesis of AgNPs using Petroselinum crispum (parsley) leaf: Spectral analysis of the particles and antibacterial study. Journal of the Mexican Chemical Society, 66(4), 480-487. [CrossRef]
58. 58. Alshwaikh, R.M.A.A., Al-Sorchee, S.M.A., Ali, K.A., Al Beer, W. (2014). Antibacterial activity of parsley and celery aqueous extract on the isolated bacteria from children UTI in Erbil city. International Journal of Advanced Research, 2(9), 895-903.
59. 59. Thangavelu, S., Balasubramanian, B., Palanisamy, S., Shanmugam, V., Natchiappan, S., Kalibulla, S.I., Rathinasamy, B., Arumugam, V.A. (2022). Characterization and phytoconstituents of Petroselinum crispum (Mill) and Coriandrum sativum (Linn) and their impacts on inflammation-An in vitro analysis against human adenocarcinoma cells with molecular docking. South African Journal of Botany, 146, 776-788. [CrossRef]
60. 60. Bashkin, A., Ghanim, M., Abu-Farich, B., Rayan, M., Miari, R., Srouji, S., Rayan, A., Falah, M. (2021). Forty-one plant extracts screened for dual antidiabetic and antioxidant functions: Evaluating the types of correlation between α-amylase ınhibition and free radical scavenging. Molecules, 26(2), 317. [CrossRef]
61. 61. Ahmed Abd Rabou, M., Ahmed Eid, F. (2017). Possible protective role of parsley extract on the diabetic pregnant rats and their fetuses. Pakistan Journal of Biological Sciences, 20(11), 552-562. [CrossRef]
62. 62. Al-khazraji, S.M. (2015). Studying the analgesic, anti-inflammatory and antipyretic properties of the aqueous extract of Petroselinum crispum in experimental animal models. IOSR Journal of Pharmacy, 5(9), 17-23.
63. 63. Akıncı, A., Eşrefoğlu, M., Taşlıdere, E., Ateş, B. (2017). Petroselinum crispum is effective in reducing stress-induced gastric oxidative damage. Balkan Medical Journal, 34, 53-59. [CrossRef]
64. 64. Sangeetha, T., Ibrahim, K.S., Deepa, S., Balamuralikrishnan, B., Arun, M., Velayuthaprabhu, S., Saradhadevi, K.M., Anand, A.V. (2022). Efficiency of Coriandrum sativum (Linn.) and Petroselinum crispum (Mill.) in enhancing iron absorption: An in silico and in vitro approach. Evidence-Based Complementary and Alternative Medicine, 2022, 1-8. [CrossRef]
65. 65. Al-Yousofy, F., Gumaih, H., Ibrahim, H., Alasbahy, A. (2017). Parsley! Mechanism as antiurolithiasis remedy. American Journal of Clinical and Experimental Urology, 5(3), 55-62.
66. 66. Abdel Bar, F., Foudah, A., Majrashi, A., Dossery, F.A., Galala, A. (2022). In-vitro evaluation of some traditional medicinal plants on calcium oxalate urolithiasis. Emirates Journal of Food and Agriculture, 33(12), 1018-1027. [CrossRef]
67. 67. Soliman, M.M., Nassan, M.A., Aldhahrani, A., Althobaiti, F., Mohamed, W.A. (2020). Molecular and histopathological study on the ameliorative impacts of Petroselinum crispum and Apium graveolens against experimental hyperuricemia. Scientific Reports, 10(1), 9512. [CrossRef]
68. 68. Rahmat, A., Ahmad, N.S.S., Ramli, N.S. (2018). Parsley (Petroselinum crispum) supplementation attenuates serum uric acid level and improves liver and kidney structures in oxonate-induced hyperuricemic rats. Oriental Pharmacy and Experimental Medicine, 19(4), 393-401. [CrossRef]
69. 69. Farshori, N.N., Al-Sheddi, E.S., Al-Oqail, M.M., Musarrat, J., Al-Khedhairy, A.A., Siddiqui, M.A. (2013). Anticancer activity of Petroselinum sativum seed extracts on MCF-7 human breast cancer cells. Asian Pacific Journal of Cancer Prevention 14, 5719-5723. [CrossRef]
70. 70. Schröder, L., Koch, J., Mahner, S., Kost, B.P., Hofmann, S., Jeschke, U., Haumann, J., Schmedt, J., Richter, D.U. (2017). The Effects of Petroselinum crispum on estrogen receptor-positive benign and malignant mammary cells (MCF12A/MCF7). Anticancer Research, 37, 95-102. [CrossRef]
71. 71. Aissani, N., Albouchi, F., Sebai, H. (2021). Anticancer effect in human glioblastoma and antioxidant activity of Petroselinum crispum L. methanol extract. Nutrition and Cancer, 73(11-12), 2605-2613. [CrossRef]
72. 72. Danciu, C., Zupko, I., Bor, A., Schwiebs, A., Radeke, H., Hancianu, M., Cioanca, O., Alexa, E., Oprean, C., Bojin, F., Soica, C., Paunescu, V., Dehelean, C.A. (2018). Botanical therapeutics: Phytochemical screening and biological assessment of chamomile, parsley and celery extracts against A375 human melanoma and dendritic cells. International Journal of Molecular Sciences, 19, 3624. [CrossRef]
73. 73. Zare-Bidaki, M., Ghasempour, A., Mohammadparast-Tabas, P., Ghoreishi, S.M., Alamzadeh, E., Javanshir, R., Le, B.N., Barakchi, M., Fattahi, M., Mortazavi-Derazkola, S. (2023). Enhanced in vivo wound healing efficacy and excellent antibacterial, antifungal, antioxidant and anticancer activities via AgNPs@PCS. Arabian Journal of Chemistry, 16(10), 105194. [CrossRef]
74. 74. Ede, S., Özbeyli, D., Erdoğan, Ö., Çevik, Ö., Kanpalta, F., Ercan, F., Yanardağ, R., Saçan, Ö., Ertik, O., Yüksel, M., Şener, G. (2023). Hepatoprotective effects of parsley (Petroselinum crispum) extract in rats with bile duct ligation. Arab Journal of Gastroenterology, 24(1), 45-51. [CrossRef]
75. 75. Bastampoor, F., Hosseini, S.E., Shariati, M., Mokhtari, M. (2021). Exposure to aqueous-alcoholic extract of parsley leaves (Petroselinum crispum) in lead-treated rats alleviate liver damage. Kafkas Universitesi Veteriner Fakultesi Dergisi, 27(6), 717-723. [CrossRef]
76. 76. Nouioura, G., Kettani, T., Tourabi, M., Elousrouti, L.T., Al Kamaly, O., Alshawwa, S.Z., Shahat, A.A., Alhalmi, A., Lyoussi, B., Derwich, E. (2023). The protective potential of Petroselinum crispum (Mill.) Fuss. on paracetamol-induced hepatio-renal toxicity and antiproteinuric effect: A biochemical, hematological, and histopathological study. Medicina, 59(10), 1814. [CrossRef]
77. 77. Abu-Serie, M.M., Habashy, N.H., Maher, A.M. (2019). In vitro anti-nephrotoxic potential of Ammi visnaga, Petroselinum crispum, Hordeum vulgare, and Cymbopogon schoenanthus seed or leaf extracts by suppressing the necrotic mediators, oxidative stress and inflammation. BMC Complementary and Alternative Medicine, 19(1), 149. [CrossRef]
78. 78. Vranješ, M., Popovic´, B.M., Štajner, D., Ivetic´, V., Mandic´, A., Vranješ, D. (2016). Effects of bearberry, parsley and corn silk extracts on diuresis, electrolytes composition, antioxidant capacity and histopathological features in mice kidneys. Journal of Functional Foods, 21, 272-282. [CrossRef]
79. 79. Nusair, S.D., Zainalabdeen, E.A., Alshogran, O.Y., Alkaraki, A. (2022). Evaluation of orellanine-induced toxicity from the mushroom Cortinarius orellanus and the antagonistic effect of Petroselinum crispum. Toxicon, 214, 1-7. [CrossRef]
80. 80. Rezazad M, Farokhi F. (2014). Protective effect of Petroselinum crispum extract in abortion using prostadin-induced renal dysfunction in female rats. Avicenna Journal of Phytomedicine, 4(5), 312-319.
81. 81. Maodaa, S.N., Allam, A.A., Ajarem, J., Abdel‑Maksoud, M.A., Al‑Basher, G.I., Wang, Z.Y. (2016). Effect of parsley (Petroselinum crispum, Apiaceae) juice against cadmium neurotoxicity in albino mice (Mus Musculus). Behavioral and Brain Functions, 12, 6. [CrossRef]
82. 82. Salahshoor, M.R., Abdolmaleki, A., Jalili, C., Ziapoor, A., Roshankhah, S. (2020). Improvement of Petroselinum crispum on morphine toxicity in prefrontal cortex in rats. International Journal of Applied & Basic Medical Research, 10(2), 110-116. [CrossRef]
83. 83. Ozel, A.B., Cilingir‐Kaya, O.T., Sener, G., Ozbeyli, D., Sen, A., Sacan, O., Yanardag, R., Yarat, A. (2021). Investigation of possible neuroprotective effects of some plant extracts on brain in bile duct ligated rats. Journal of Food Biochemistry, 45(8), e13835. [CrossRef]
84. 84. Şener, G., Karakadıoglu, G., Ozbeyli, D., Ede, S., Yanardag, R., Sacan, O., Aykac, A. (2022). Petroselinum crispum extract ameliorates scopolamine-induced cognitive dysfunction: Role on apoptosis, inflammation and oxidative stress. Food Science and Human Wellness, 11(5), 1290-1298. [CrossRef]
85. 85. Ertik, O., Pazarbaşı, S.E., Sener, G., Sacan, O., Yanardag, R. (2023). Petroselinum crispum extract prevents scopolamine-induced lens damage in rats. Chemistry & Biodiversity, 20(11), e202300776. [CrossRef]
86. 86. Badr, G.M., Algefare, A.I., Alfwuaires, M.A. (2021). Antioxidant potential of parsley leaf (Petroselinum crispum) essential oil on hypothyroidism and testicular injury in mice intoxicated by carbon tetrachloride. BioMed Research International, 2021, 9989174. [CrossRef]
87. 87. Hassan, R.F., Kadim, H.M. (2022). Comparative effects of phenolic extract as an ointment dosage form in inducing wound healing in mice and β-sitosterol in experimentally induced acute wound healing in mice. (2022). Journal of Pharmaceutical Negative Results, 13(3), 194-203. [CrossRef]
88. 88. Almutairi, A.A., Ahmed, W.E., Algonaiman, R., Alhomaid, R.M., Almujaydil, M.S., Althwab, S.A., Elhassan, A.E.M., Mousa, H.M. (2023). Hypolipidemic, hypoglycemic, and ameliorative effects of boiled parsley (Petroselinum crispum) and mallow (Corchorus olitorius) leaf extracts in high-fat diet-fed rats. Foods, 12(23), 4303. [CrossRef]
89. 89. El Rabey, H.A., Al-Seeni, M.N., Al-Ghamdi, H.B. (2017). Comparison between the hypolipidemic activity of parsley and carob in hypercholesterolemic male rats. BioMed Research International, 2017, 3098745. [CrossRef]
90. 90. El-Bahr, S.M., Elbakery, A.M., El-Gazzar, N., Amin, A.A., Al-Sultan, S., Alfattah, M.A., Shousha, S., Alhojaily, S., Shathele, M., Sabeq, I.I., Hamouda, A.F. (2021). Biosynthesized iron oxide nanoparticles from Petroselinum crispum leaf extract mitigate lead-acetate-induced anemia in male albino rats: Hematological, Biochemical and Histopathological Features. Toxics, 9(6), 123. [CrossRef]
91. 91. Hozayen, W.G., El-Desouky, M.A., Soliman, H.A., Ahmed, R.R., Khaliefa, A.K. (2016). Antiosteoporotic effect of Petroselinum crispum, Ocimum basilicum and Cichorium intybus L. in glucocorticoid-induced osteoporosis in rats. BMC Complementary and Alternative Medicine, 16, 165. [CrossRef]
92. 92. Es-Safi, I., Mechchate, H., Amaghnouje, A., Kamaly, O.M.A., Jawhari, F.Z., Imtara, H., Grafov, A., Bousta, D. (2021). The Potential of parsley polyphenols and their antioxidant capacity to help in the treatment of depression and anxiety: An in vivo subacute study. Molecules, 26(7), 2009. [CrossRef]
93. 93. Sánchez-Quintero, M.J., Delgado, J., Medina-Vera, D., Becerra-Muñoz, V.M., Queipo-Ortuño, M.I., Estévez, M., Plaza-Andrades, I., Rodríguez-Capitán, J., Sánchez, P.L., Crespo-Leiro, M.G., Jiménez-Navarro, M.F., Pavón-Morón, F.J. (2022). Beneficial effects of essential oils from the Mediterranean diet on gut microbiota and their metabolites in ischemic heart disease and type-2 diabetes mellitus. Nutrients, 14(21), 4650. [CrossRef]
94. 94. Ertik, O., Sacan, O., Yanardag, R. (2023). Anti-adenosine deaminase, anti-neuraminidase, anti-xanthine oxidase, anti-acetylcholinesterase and antioxidant activities of parsley extract. Journal of Herbal Medicine, 42, 100787. [CrossRef]
95. 95. Bouasla, A., Gassi, H.E., Lisiecka, K., Wójtowicz, A. (2022). Application of parsley leaf powder as functional ingredient in fortified wheat pasta: Nutraceutical, physical and organoleptic characteristics. International Agrophysics, 36(1), 37-45. [CrossRef]
96. 96. Covaliov, E., Deseatnicova, O., Resitca, V., Suhodol, N., Grosu, C., Siminiuc, R. (2022). Impact of plant additives: Parsley (Petroselinum crispum) leaves and red bell pepper (Capsicum annuum) on the quality of eggless wheat pasta. Czech Journal of Food Sciences, 40(4), 281-289. [CrossRef]
97. 97. Dziki, D., Hassoon, W.H., Biernacka, B., Gawlik-Dziki, U. (2022). Dried and powdered leaves of parsley as a functional additive to wheat bread. Applied Sciences, 12(15), 7930. [CrossRef]
98. 98. Nashtar, S.B., Hashim, I., Al-Attar, Z. (2018). The effect of parsley in the treatment of UTI in Iraqi patients. International Journal of Medical Research & Health Sciences, 7(8), 1-7.
99. 99. Khosravan, S., Alami, A., Mohammadzadeh-Moghadam, H., Ramezani, V. (2017). The effect of topical use of Petroselinum crispum (parsley) versus that of hydroquinone cream on reduction of epidermal melasma. Holistic Nursing Practice, 31(1), 16-20. [CrossRef]
100. 100. Gnintoungbe, G.S., Medehouenou, T.C.M., Adounkpe, F., Akpovi, C., Loko, F. (2023). Phytochemical screening, antioxidant activity and safety of Petroselinum crispum (Mill.) AW Hill Apiaceae leaves grown in Benin. Open Journal of Applied Sciences, 13(01), 36-50. [CrossRef]
101. 101. Lim, H., Lee, S.Y., Ho, L.Y., Sit, N.W. (2023). Mosquito larvicidal activity and cytotoxicity of the extracts of aromatic plants from Malaysia. Insects, 14(6), 512. [CrossRef]
102. 102. Tisserand, R., Young, R. (2014). The reproductive system. In: Essential Oil Safety: A Guide for Health Care Professionals (2nd Edition) (pp. 147-163). London: Churchill Livingstone [CrossRef]
103. 103. Daradkeh, G., Essa, M.M. (2018). Parsley. In: Ambrose, D.C.P., Manickavasagan, A., Naik, R. (Eds), Leafy Medicinal Herbs: Botany, Chemistry, Postharvest Technology and Uses, (pp. 189-197). India: CABI.
104. 104. Evadgian, A., Bharatha, A., Cohall, D. (2022). Use of cheminformatics to determine potential drug interactions between popular Barbadian botanical medicines and antihypertensive drugs. ACS Omega, 7(49), 44603-44619. [CrossRef]
105. 105. Ahmad, R., Ahmad, N., Alshayban, D.M., Alamer, M.A., Alkhalifah, A.H., Almomatten, H.M. (2019). Pharmacokinetic interaction study for simvastatin and parsley and its plasma quantification using LC-MS: A focus on drug metabolic enzymes. Iranian Red Crescent Medical Journal, 21(2), e85783. [CrossRef]
106. 106. Kurtaran, M., Koc, N.S., Aksun, M.S., Yildirim, T., Yilmaz, Ş.R., Erdem, Y. (2021). Petroselinum crispum, a commonly consumed food, affects sirolimus level in a renal transplant recipient: A case report. Therapeutic Advances in Drug Safety, 12, 20420986211009358. [CrossRef]