NEW APPROACHES IN HUMAN PAPILLOMAVIRUS (HPV) TREATMENT: ACTIVE HEXOSE-RELATED COMPOUND (AHCC®)

Yıl 2024, , 714 - 726, 20.05.2024

Zehra Keçeci , Cansu Bölükbaş , Hazal Eken

https://doi.org/10.33483/jfpau.1364203

Öz

Objective: Human papillomavirus (HPV) poses a serious public health problem as it is the most common sexually transmitted viral infection that can cause warts and cancer on the skin and mucous membranes, depending on its subtypes. Current treatment options only aim to remove warts and improve symptoms, without eradicating the disease. In addition to these treatments, it has been shown that the use of various natural products that support the immune system can be beneficial in the treatment of HPV. Although the pharmacological effects of mushroom extracts on the immune system have not been fully elucidated, they have been used for various health problems in different parts of the world for many years. This review focused on the effects of AHCC®, a mushroom extract, on HPV infection.
Result and Discussion: AHCC®, a standardized, cultured extract of the edible mushroom Lentinula edodes, enriched in acetylated α-1,4-glucans, is among the prominent alternative treatment options in the treatment of HPV due to its pharmacological effects. Preclinical and clinical studies show that AHCC® may be a promising new option for HPV treatment by supporting the immune system.

Anahtar Kelimeler

AHCC®, HPV, nutritional supplements

İNSAN PAPİLLOMA VİRÜSÜ (HPV) TEDAVİSİNDE YENİ YAKLAŞIMLAR: AKTİF HEKSOZ İLİŞKİLİ BİLEŞİK (AHCC®)

Öz

Amaç: İnsan papilloma virüsü (HPV) alt tiplerine bağlı olarak cilt ve mukoza zarlarında siğil ve kanser oluşumuna sebep olabilen cinsel yolla bulaşan en yaygın viral enfeksiyon olması sebebi ile ciddi bir halk sağlığı problemi oluşturmaktadır. Günümüzde HPV tedavisinde hastalığın eradikasyonunu sağlamayan, sadece dışa doğru büyüyen siğillerin uzaklaştırılmasını ve semptomların iyileştirilmesini amaçlayan seçenekler mevcuttur. Bu tedavilerin dışında immün sistemi destekleyici çeşitli doğal ürünlerin kullanımının da HPV tedavisinde faydalı olabileceği gösterilmiştir. Mantar ekstraktlarının bağışıklık sistemi üzerindeki kesin etkileri tam olarak aydınlatılamamış olsa da uzun yıllardan beri dünyanın farklı bölgelerinde çeşitli sağlık sorunları için kullanılmaktadır. Bu derlemede bir mantar ekstratı olan AHCC®’nin HPV enfeksiyonu üzerindeki etkilerine odaklanılmıştır.
Sonuç ve Tartışma: Yenilebilir bir mantar olan Lentinula edodes'in asetillenmiş α-1,4-glukanlar bakımından zenginleştirilmiş, standartlaştırılmış, kültürlenmiş bir özütü olan AHCC® sahip olduğu çeşitli farmakolojik etkileri nedeni ile HPV tedavisinde öne çıkan alternatif tedavi seçenekleri arasında yer almaktadır. Yapılan preklinik ve klinik çalışmalar, AHCC®’nin bağışıklık sistemini destekleyerek HPV tedavisi için umut veren yeni bir seçenek olabileceğini göstermektedir.

Anahtar Kelimeler

AHCC®, besin takviyeleri, HPV

Kaynakça

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